The 2022 Extreme Heatwave in Shanghai,Lower Reaches of the Yangtze River Valley:Combined Influences of Multiscale Variabilities

In the summer of 2022,China(especially the Yangtze River Valley,YRV)suffered its strongest heatwave(HW)event since 1961.In this study,we examined the influences of multiscale variabilities on the 2022 extreme HW in the lower reaches of the YRV,focusing on the city of Shanghai.We found that about 1/3 of the 2022 HW days in Shanghai can be attributed to the long-term warming trend of global warming.During mid-summer of 2022,an enhanced western Pacific subtropical high(WPSH)and anomalous double blockings over the Ural Mountains and Sea of Okhotsk,respectively,were associated with the persistently anomalous high pressure over the YRV,leading to the extreme HW.The Pacific Decadal Oscillation played a major role in the anomalous blocking pattern associated with the HW at the decadal time scale.Also,the positive phase of the Atlantic Multidecadal Oscillation may have contributed to regulating the formation of the double-blocking pattern.Anomalous warming of both the warm pool of the western Pacific and tropical North Atlantic at the interannual time scale may also have favored the persistency of the double blocking and the anomalously strong WPSH.At the subseasonal time scale,the anomalously frequent phases 2-5 of the canonical northward propagating variability of boreal summer intraseasonal oscillation associated with the anomalous propagation of a weak Madden-Julian Oscillation suppressed the convection over the YRV and also contributed to the HW.Therefore,the 2022 extreme HW originated from multiscale forcing including both the climate warming trend and air-sea interaction at multiple time scales.

Efficient Simultaneous Detection of Metabolites Based on Electroenzymatic Assembly Strategy

Objective and Impact Statement:We describe an electroenzymatic mediator(EM)sensor based on an electroenzymatic assembly peak separation strategy,which can efficiently realize the simultaneous detection of 3 typical cardiovascular disease(CVD)metabolites in 5μl of plasma under one test.This work has substantial implications toward improving the efficiency of chronic CVD assessment.Introduction:Monitoring CVD of metabolites is strongly associated with disease risk.Independent and time-consuming detection in hospitals is unfavorable for chronic CVD management.Methods:The EM was flexibly designed by the cross-linking of electron mediators and enzymes,and 3 EM layers with different characteristics were assembled on one electrode.Electrons were transferred under tunable potential;3 metabolites were quantitatively detected by 3 peak currents that correlated with metabolite concentrations.Results:In this study,the EM sensor showed high sensitivity for the simultaneous detection of 3 metabolites with a lower limit of 0.01 mM.The linear correlation between the sensor and clinical was greater than 0.980 for 242 patients,and the consistency of risk assessment was 94.6%.Conclusion:Metabolites could be expanded by the EM,and the sensor could be a promising candidate as a home healthcare tool for CVD risk assessment.

Progress in drug delivery system for fibrosis therapy

Fibrosis is a necessary process in the progression of chronic disease to cirrhosis or even cancer,which is a serious disease threatening human health.Recent studies have shown that the early treatment of fibrosis is turning point and particularly important.Therefore,how to reverse fibrosis has become the focus and research hotspot in recent years.So far,the considerable progress has been made in the development of effective anti-fibrosis drugs and targeted drug delivery.Moreover,the existing research results will lay the foundation for more breakthrough delivery systems to achieve better anti-fibrosis effects.Herein,this review summaries anti-fibrosis delivery systems focused on three major organ fibrotic diseases such as liver,pulmonary,and renal fibrosis accompanied by the elaboration of relevant pathological mechanisms,which will provide inspiration and guidance for the design of fibrosis drugs and therapeutic systems in the future.

The Synergism between Methanogens and Methanotrophs and the Nature of their Contributions to the Seasonal Variation of Methane Fluxes in a Wetland:The Case of Dajiuhu Subalpine Peatland

Wetland ecosystems are the most important natural methane(CH_(4))sources,whose fluxes periodically fluctuate.Methanogens(methane producers)and methanotrophs(methane consumers)are considered key factors affecting CH_(4)fluxes in wetlands.However,the symbiotic relationship between methanogens and methanotrophs remains unclear.To help close this research gap,we collected and analyzed samples from four soil depths in the Dajiuhu subalpine peatland in January,April,July,and October 2019 and acquired seasonal methane flux data from an eddy covariance(EC)system,and investigated relationships.A phylogenetic molecular ecological networks(pMENs)analysis was used to identify keystone species and the seasonal variations of the co-occurrence patterns of methanogenic and methanotrophic communities.The results indicate that the seasonal variations of the interactions between methanogenic and methanotrophic communities contributed to CH_(4)emissions in wetlands.The keystone species discerned by the network analysis also showed their importance in mediating CH_(4)fluxes.Methane(CH_(4))emissions in wetlands were lowest in spring;during this period,the most complex interactions between microbes were observed,with intense competition among methanogens while methanotrophs demonstrated better cooperation.Reverse patterns manifested themselves in summer when the highest CH_(4)flux was observed.Methanoregula formicica was negatively correlated with CH_(4)fluxes and occupied the largest ecological niches in the spring network.In contrast,both Methanocella arvoryzae and Methylocystaceae demonstrated positive correlations with CH_(4)fluxes and were better adapted to the microbial community in the summer.In addition,soil temperature and nitrogen were regarded as significant environmental factors to CH_(4)fluxes.This study was successful in explaining the seasonal patterns and microbial driving mechanisms of CH_(4)emissions in wetlands.

Effect of diacylglycerol acyltransferase 2overexpression in 3T3-L1 is associated to an increase in mono-unsaturated fatty acid accumulation

Background：Fatty acid（FA） composition is the most important parameter affecting the flavor and nutritional value of the meat.The final and the only committed step in the biosynthesis of triglycerides is catalyzed by diacylglycerol acyltransferase 2（DGAT2）.The role of DGAT2 in lipid accumulation has been demonstrated in adipocytes,However,little is known about the effect of DGAT2 on the FA composition of these cells.Methods：To investigate the role of DGAT2 in regulating lipid accumulation,FA composition and the expression of adipogenic genes,we cloned the open reading frame of the porcine DGAT2 gene and established 3T3-L1 cells that overexpressed DGAT2.Cells were then cultured in differentiation medium（DM） without FA,with a mixture of FAs（FA-DM）,or containing a ^（13）C stable isotope-labeled FA mixture（IFA-DM）.The FA composition of adipocytes was analyzed by gas chromatography-mass spectrometry and gas chromatography-isotope ratio mass spectrometry.Quantitative PCR and western blotting were employed to detect expression of adipogenic genes in 3T3-L1 adipocytes cultured with FA-DM for 12 d.Results：The triacylglyceride（TAG） content was significantly higher in 3T3-L1 adipocytes overexpressing DGAT2 than in control cells.When cultured in DM or FA-DM for 12 d,cells overexpressing DGAT2 showed a higher proportion of unsaturated FAs（C16：1 and C18：1）.However,when cells overexpressing DGAT2 were cultured with FA-DM for30 min,the FA composition was almost identical to that of controls.Further,the proportion of stable isotope-labeled FAs were similar in 3T3-L1 adipocytes overexpressing DGAT2 and control cells cultured in IFA-DM for 12 d.These results collectively indicate that the higher proportion of mono-unsaturated FAs,C16：1 and C18：1,may originate from de novo FA synthesis but not from the uptake of specific FAs from the medium.This hypothesis is further supported by evidence that both mRNA and protein expression of genes involved in FA synthesis（ACACA,FASN,SCD1,and A-FABP）were significantly higher in cells overexpressing DGAT2 than in control cells.Conclusions：In conclusion,our study revealed that TAG accumulation,the proportion of MUFAs,and the expression of adipogenic genes were higher in 3T3-L1 cells overexpressing DGAT2 than in control cells.

Stream-computing of High Accuracy On-board Real-time Cloud Detection for High Resolution Optical Satellite Imagery

This paper focuses on the time efficiency for machine vision and intelligent photogrammetry, especially high accuracy on-board real-time cloud detection method. With the development of technology, the data acquisition ability is growing continuously and the volume of raw data is increasing explosively. Meanwhile, because of the higher requirement of data accuracy, the computation load is also becoming heavier. This situation makes time efficiency extremely important. Moreover, the cloud cover rate of optical satellite imagery is up to approximately 50%, which is seriously restricting the applications of on-board intelligent photogrammetry services. To meet the on-board cloud detection requirements and offer valid input data to subsequent processing, this paper presents a stream-computing of high accuracy on-board real-time cloud detection solution which follows the “bottom-up” understanding strategy of machine vision and uses multiple embedded GPU with significant potential to be applied on-board. Without external memory, the data parallel pipeline system based on multiple processing modules of this solution could afford the “stream-in, processing, stream-out” real-time stream computing. In experiments, images of GF-2 satellite are used to validate the accuracy and performance of this approach, and the experimental results show that this solution could not only bring up cloud detection accuracy, but also match the on-board real-time processing requirements.

Dynamic analysis of a latent HIV infection model with CTL immune and antibody responses

This paper develops a mathematical model to investigate the Human Immunodeficiency Virus(HIV)infection dynamics.The model includes two transmission modes(cell-to-cell and cell-free),two adaptive immune responses(cytotoxic T-lymphocyte(CTL)and antibody),a saturated CTL immune response,and latent HIV infection.The existence and local stability of equilibria are fully characterized by four reproduction numbers.Through sensitivity analyses,we assess the partial rank correlation coefficients of these reproduction numbers and identify that the infection rate via cell-to-cell transmission,the number of new viruses produced by each infected cell during its life cycle,the clearance rate of free virions,and immune parameters have the greatest impact on the reproduction numbers.Additionally,we compare the effects of immune stimulation and cell-to-cell spread on the model's dynamics.The findings highlight the significance of adaptive immune responses in increasing the population of uninfected cells and reducing the numbers of latent cells,infected cells,and viruses.Furthermore,cell-to-cell transmission is identified as a facilitator of HIV transmission.The analytical and numerical results presented in this study contribute to a better understanding of HIV dynamics and can potentially aid in improving HIV management strategies.

The high-resolution community velocity model V2.0 of southwest China,constructed by joint body and surface wave tomography of data recorded at temporary dense arrays

The Sichuan-Yunnan area is located at the southeastern margin of the Tibetan Plateau,where tectonic movement is strong with deep and large faults distributed in a staggered manner,which results in strong seismic activities and severe earthquake hazards.Since the 21st century,several earthquakes of magnitude 7.0 or above occurred in this region,which have caused huge casualties and economic losses,especially the 2008 M_(s)8.0 Wenchuan earthquake.At present,earthquake monitoring and source parameter inversion,strong earthquake hazard analysis and disaster assessment are still the focus of seismological researches in the Sichuan-Yunnan region.Regional high-precision 3D community velocity models are fundamental for these studies.In this paper,by assembling seismic observations at permanent seismic stations and several temporary dense seismic arrays in this region,we obtained about 7.06 million body wave travel time data(including absolute and differential travel times)using a newly developed artificial intelligence body wave arrival time picking method and about 100,000 Rayleigh wave phase velocity dispersion data in the period range of 5-50 s from ambient noise cross-correlation technique.Based on this abundant dataset,we obtained the three-dimensional high resolution V_p and V_(s)model in the crust and uppermost mantle of southwest(SW)China by adopting the joint body and surface wave travel time tomography method considering the topography effect starting from the first version of community velocity model in SW China(SWChina CVM-1.0).Compared to SWChina CVM-1.0,this newly determined velocity model has higher resolution and better data fitness.It is accepted by the China Seismic Experimental Site as the second version of the community velocity model in SW China(SWChina CVM-2.0).The new model shows strong lateral heterogeneities in the shallow crust.Two disconnected low velocity zones are observed in the middle to lower crust,which is located in the Songpan-Ganzi block and the northern Chuandian block to the west of the Longmenshan-Lijiang-Xiaojinhe fault,and beneath the Xiaojiang fault zone,respectively.The inner zone of the Emeishan large igneous province(ELIP)exhibits a high velocity anomaly,which separates the two aforementioned low velocity anomalies.Low velocity anomaly is also shown beneath the Tengchong volcano.The velocity structures in the vicinity of the 2008 M_(s)8.0 Wenchuan earthquake,the 2013 M_(s)7.0Lushan earthquake and the 2017 M_(s)7.0 Jiuzhaigou earthquake mainly show high V_(p)and V_(s)anomalies and the mainshocks are basically located at the transition zone between the high and low velocity anomalies.Along with the segmentation characteristics of seismic activity,we suggest that areas with significant changes in velocity structures,especially in active fault zones,might have a greater potential to generate moderate to strong earthquakes.

国家自豪感对亲社会行为的影响:群体类型和忠诚度的调节作用

集体自豪是个体由于本群体的成就或与外群体相比具有一定优越性而体验到的自豪感,其核心是对本群体的认同.例如,当我们都属于一个大群体"中国"的时候,中国人的身份就成为了我们群体的身份象征.在我们不断加强的国家自豪感的宣传教育的过程中,中国人本身对本群体和其他群体是更加"亲近"还是更加"排斥"?本研究招募成年中国公民为参与者,采用被试间设计,将被试随机分为自豪、积极和中性启动组.实验1选用情绪图片作为启动材料,采用独裁者游戏和最后通牒游戏范式测量个体的公平偏好;实验2选用文本作为启动材料,采用信任博弈游戏实验范式测量个体的人际信任.改变分配或投资对象为内群体(中国人)和外群体(外国人),并按照《道德基础量表》中的忠诚分量表得分高低,将被试分为高忠诚组和低忠诚组,检验国家自豪对内外群体亲社会行为的影响和忠诚度在其中的调节作用.结果表明:高忠诚组的个体更容易产生内群体偏好.国家自豪启动能减弱内群体偏好,并会增加高忠诚个体的公平偏好和人际信任.未来的研究可区分不同来源的国家自豪,明确国家自豪的测量方式,探究其他可能影响国家自豪对亲社会行为效应的人格变量,并进一步研究国家自豪对亲社会行为影响的心理机制.

Shear wave velocity structure of the crust and upper mantle in Southeastern Tibet and its geodynamic implications

Southeastern Tibet,which has complex topography and strong tectonic activity,is an important area for studying the subsurface deformation of the Tibetan Plateau.Through the two-station method on 10-year teleseismic Rayleigh wave data from 132 permanent stations in the southeastern Tibetan Plateau,which incorporates ambient noise data,we obtain the interstation phase velocity dispersion data in the period range of 5–150s.Then,we invert for the shear wave velocity of the crust and upper mantle through the direct 3-D inversion method.We find two low-velocity belts in the mid-lower crust.One belt is mainly in the SongPan-GangZi block and northwestern part of the Chuan-Dian diamond block,whereas the other belt is mainly in the Xiaojiang fault zone and its eastern part,the Yunnan-Guizhou Plateau.The low-velocity belt in the Xiaojiang fault zone is likely caused by plastic deformation or partial melting of felsic rocks due to crustal thickening.Moreover,the significant positive radial anisotropy(VSH>VSV)around the Xiaojiang fault zone further enhances the amplitude of low velocity anomaly in our VSVmodel.This crustal low-velocity zone also extends southward across the Red River fault and farther to northern Vietnam,which may be closely related to heat sources in the upper mantle.The two low-velocity belts are separated by a high-velocity zone near the Anninghe-Zemuhe fault system,which is exactly in the inner and intermediate zones of the Emeishan large igneous province(ELIP).We find an obvious high-velocity body situated in the crust of the inner zone of the ELIP,which may represent maficultramafic material that remained in the crust when the ELIP formed.In the upper mantle,there is a large-scale low-velocity anomaly in the Indochina and South China blocks south of the Red River fault.The low-velocity anomaly gradually extends northward along the Xiaojiang fault zone into the Yangtze Craton as depth increases.Through our velocity model,we think that southeastern Tibet is undergoing three different tectonic modes at the same time:(1)the upper crust is rigid,and as a result,the tectonic mode is mainly rigid block extrusion controlled by large strike-slip faults;(2)the viscoplastic materials in the middlelower crust,separated by rigid materials related to the ELIP,migrate plastically southward under the control of the regional stress field and fault systems;and(3)the upper mantle south of the Red River fault is mainly controlled by large-scale asthenospheric upwelling and may be closely related to lithospheric delamination and the eastward subduction and retreat of the Indian plate beneath Burma.

Contribution of Water Vapor to the Record-Breaking Extreme Meiyu Rainfall along the Yangtze River Valley in 2020

A record-breaking extreme Meiyu rainfall occurred along the Yangtze River valley(YRV)in 2020 since 1961,persisting from 11 June to 31 July with the largest amount and the highest intensity.From the aspect of water vapor,the causes of its formation are revealed in this study.The 2020 Meiyu rainfall amount is directly attributed to the greatly enhanced vertically integrated water vapor transport(IVT)convergence,which is in turn primarily determined by the mean circulation dynamic(MCD)contribution associated with anomalous East Asian summer monsoon(EASM)and the thermodynamic component(TH)contribution due to water vapor anomaly.The MCD contribution is mainly responsible for the extreme Meiyu rainfall amount and abundant water vapor convergence in the YRV,whereas the TH contribution tends to shift Meiyu rain belt northward to the Yangtze-Huaihe River valley,extending the Meiyu rainfall coverage area.Furthermore,the excessive moist static energy(MSE)associated with the largest water vapor anomaly could substantially increase the atmospheric instability,favoring the extreme 2020 Meiyu rainfall intensity.In terms of the tremendous IVT to the YRV from both the South China Sea and Bay of Bengal during the 2020 Meiyu period,the low-level anticyclone anomalies over the western North Pacific(WNP)and Bay of Bengal provide appropriate atmospheric circulation conditions,and they are generated by the super suppressed WNP convective activities as a Matsuno-Gill type response,which are further attributed to the combined warm SST anomalies in both the tropical western Indian Ocean(TWIO)and tropical Atlantic Ocean(TAO)eventually.

A preliminary study on the volcanic intrusive complex type beryllium metallogenic belt from the southeast coast of China

Beryllium(Be)is one of the unsubstitutable key metals in strategic emerging industries and national defense industries,mainly originating from volcanogenic Be deposits.Thus,volcanogenic Be deposits have become important research objects of key metal deposits,with a focus on their occurrence,metallogenic mechanism,and resource distribution.In the southeast coast of China,the Late Mesozoic volcanic intrusive complex has a good Be metallogenic background,and strong Be mineralization occurs in some areas.Field geological investigation and analyses of samples from Southeast Zhejiang as well as Northeast and Southeast Fujian indicate that Be mineralization in the southeast coast of China is closely related to the hydrothermal processes in the volcanic intrusive complex.In Southeast Zhejiang,Be ore in the Qingtian area mainly occurs in granite porphyry,with the Be content reaching 939 ppm,while strong Be mineralization from Zhangji rhyolite porphyry in the Pingyang area contains up to 11400 ppm Be.In Xiapu County,Northeastern Fujian,the Dawan Be deposit is characterized by constituents of helvite and beryl.In Pinghe County,Southeastern Fujian,the Fulishi Be ore is a quartz vein beryl-type ore.These results suggest that the volcanic intrusive complex area in the southeast coast of China has a wide range of Be mineralization and better Be metallogenic potential,and it is expected to become an important Be metallogenic belt in China.Thus,we should thoroughly investigate the Be resources of granite porphyry,rhyolite porphyry,quartz porphyry,and quartz vein in this volcanic rock area,which can provide a theoretical basis for the exploration and guiding prospecting of volcanic intrusive complex Be deposits.

Integrated microdevice with a windmill-like hole array for the clog-free,efficient,and self-mixing enrichment of circulating tumor cells

Circulating tumor cells(CTCs)have tremendous potential to indicate disease progression and monitor therapeutic response using minimally invasive approaches.Considering the limitations of affinity strategies based on their cost,effectiveness,and simplicity,size-based enrichment methods that involve low-cost,label-free,and relatively simple protocols have been further promoted.Nevertheless,the key challenges of these methods are clogging issues and cell aggregation,which reduce the recovery rates and purity.Inspired by the natural phenomenon that the airflow around a windmill is disturbed,in this study,a windmill-like hole array on the SU-8 membrane was designed to perturb the fluid such that cells in a fluid would be able to self-mix and that the pressure acting on cells or the membrane would be dispersed to allow a greater velocity.In addition,based on the advantages of fluid coatings,a lipid coating was used to modify the membrane surface to prevent cell aggregation and clogging of the holes.Under the optimal conditions,recovery rates of 93%and 90%were found for A549 and HeLa cells in a clinical simulation test of our platform with a CTC concentration of 20-100 cells per milliliter of blood.The white blood cell(WBC)depletion rate was 98.7%(n=15),and the CTC detection limit was less than 10 cells per milliliter of blood(n=6).Moreover,compared with conventional membrane filtration,the advantages of the proposed device for the rapid(2 mL/min)and efficient enrichment of CTCs without clogging were shown both experimentally and theoretically.Due to its advantages in the efficient,rapid,uniform,and clog-free enrichment of CTCs,our platform offers great potential for metastatic detection and therapy analyses.

Treatment and resource recovery from inorganic fluoride-containing waste produced by the pesticide industry

The rapid development of the fluorinated pesticide industry has produced a large amount of fluorine-containing hazardous waste, especially inorganic fluoride-containing waste（IFCW）. A two-step process, including extraction and recovery, was developed to recover fluorine as synthetic cryolite from IFCW produced by the pesticide industry. The optimum conditions for extraction were found to be a temperature of 75℃, an initial p H（p Hi） of 12, a4-hr incubation time and a liquid-to-solid ratio of 40 m L/g; these conditions resulted in a fluorine extraction ratio of 99.0%. The effects of p H and the F/Al molar ratio on fluorine recovery and the compositional, mineralogical and morphological characteristics of the cryolite products were investigated. Field-emission scanning electron microscopy of recovered precipitates showed changes in morphology with the F/Al molar ratio. Coupling Fourier transform and infrared spectroscopy, X-ray diffraction indicated that the formation of Al F3-6was restricted as increasing p H. Both the amount of fluorine recovered and the quality of the cryolite were optimized at initial p H = 3 and a F/Al molar ratio 5.75. This study proposed a reliable and environmentally friendly method for the treatment of fluoridecontaining wastes, which could be suitable for industrial applications.

Habitat Influence on the Molecular, Carbon and Hydrogen Isotope Compositions of Leaf Wax n-Alkanes in a Subalpine Basin, Central China

Epidermal leaf waxes of terrestrial higher plants have been widely utilized for the reconstructions of paleoenvironment and paleoclimate in peat deposits. In this study, specimens of four plant species growing in both peatland and non-peatland habitats were retrieved to compare their molecular, carbon(δ13 C) and hydrogen(δ2 H) isotopic compositions of leaf wax n-alkanes from a closed subalpine basin in Central China. Three of the four species show quite higher total concentrations of n-alkanes in the relatively dry non-peatland setting than in the peatland. In addition, the δ2 H values of long-chain n-alkanes are generally less depleted in the peatland and are comparable among different plant species, which is interpreted as the influence of inundation condition and the possible limited supply of photosynthetic products. This study reveals different patterns of plant wax molecular and isotopic compositions between peatland and the surrounding non-peatland conditions, and confirms the paleoenvironmental potential of leaf wax ratios on the peat sequences.

A GSH-depleted platinum(Ⅳ) prodrug triggers ferroptotic cell death in breast cancer

Cisplatin is the first-line drug for treatment of various solid tumors including breast cancer due to the broad anti-tumor spectrum and strong anti-tumor effect.However,serious side effects and long-term medication of reduced sensitivity by high GSH in tumor cells have severely restricted its further clinical application.Herein,a GSH-depleted Pt(Ⅳ)prodrug(Platin B)based on cisplatin and 4-carboxylphenylboronic acid pinacol ester was prepared to solve the problems.As an excellent GSH scavenger,4-carboxylphenylboronic acid pinacol ester could be activated by intracellular redox reactions to release quinone methide,thereby amplifying oxidative stress and leading to breast cancer ferroptosis therapy.Interestingly,the consumption of GSH can also reduce cisplatin inactivation,enhance the sensitivity of tumor cells to cisplatin and efficiently induce apoptosis/ferroptosis.This work highlights the use of GSH scavenger for triggering ferroptotic cell death in breast cancer.

Seasonal variations of leaf wax n-alkane distributions and δ^(2) H values in peat-forming vascular plants from the Dajiuhu peatland, central China

Leaf wax n-alkane compositions have been widely applied to reconstruct paleoclimate histories in peat deposits,yet understanding of how the n-alkanes vary during seasonal plant growth remains limited.Here we report variations in the molecular and wax-derived nalkane hydrogen isotope(δ^(2) Halk)in the three dominant vascular plant species(Sanguisorba officinalis,Carex argyi,Euphorbia esula)and surface peat deposits nearby from the Dajiuhu peatland over a growing season.All three species show a relatively high carbon preference index(CPI)in the beginning of the growing season,with the CPI values reaching as high as 50 in two of the three species.Two species(S.officinalis,E.esula)display relatively stable average chain length(ACL)values over the four sampling intervals,with standard derivations of 0.2-0.3.In contrast,C.argyi exhibits a significant fluctuation of ACL values(averaging 28.11.4)over the growing season.Theδ^(2) Halk in all three species decreased during leaf growth.In the final stage of growth,theδ^(2) Halk values of the three species are similar to those in the surface peats collected from the peatland.Combining the results of our measurements of alkane concentration andδ^(2) H values,it is likely that de novo synthesis of leaf wax n-alkanes in the peatforming plant species is mainly at the early stage of leaf development.In the following months,the removal process exceeds renewal,resulting in a general decrease of the concentration of the total n-alkanes and the integratedδ^(2) Halk values.Thus theδ^(2) Halk values probably integrate the environmental variations at the end of the plant growth period rather than the whole period or the early growth period.These results are significant and have the potential to improve the utility ofδ^(2) Halk values in paleoenvironmental reconstructions.

Erratum

This erratum is to report a figure misplacement in Wang et al.(2021)entitled“Contribution of Water Vapor to the Record-Breaking Extreme Meiyu Rainfall along the Yangtze River Valley in 2020.”In Wang et al.(2021),Fig.2b should be switched with Fig.2d(note that the labels on top of Figs.2b and 2d need not change).The correct figure as a whole is given here(Fig.2).

Disruption of KDM4C-ALDH1 A3 feed-forward loop inhibits sternness,tumorigenesis and chemoresistance of gastric cancer stem cells

Dear Editor,Gastric cancer(GC)is a considerable global health burden;the median survival of advaneed GC is less than 1 year.^(1)Cancer stem cells(CSCs),a small population of cancer cells with stem cell-like properties,are the major cause of treatme nt failure,in eluding GC,2 however,the mechanisms underlying stemness maintenanee of GC stem cells(GCSCs)are still poorly understood.