Reinforcement Technology for Soft Soil Roadbed in the Widened Section of Expressway Expansion

This article examines the soft soil roadbed reinforcement technology for widened sections of highways in a specific project.It provides an overview of the project,the principles of soft soil roadbed reinforcement technology for wide sections,and its practical application.The analysis aims to offer guidance on applying soft soil roadbed wide section reinforcement technology and enhancing the overall quality of similar projects.

Analysis and Comparison of Slope-cutting Widening Schemes in Highway Reconstruction and Expansion Project Based on MIDAS Software

In this paper,the geological condition of the right-side slope of the K114+694–K115+162 section of Yong-tai-wen Expressway is investigated and analyzed with the results showing that the strength of rock mass is the main contributor to the stability of the slope.Then,two widening schemes are proposed,which are the steep slope with strong support and the gentle slope with general support schemes.The static/slope module of MIDAS GTS finite element analysis software and the strength reduction method were used to compare the two schemes.The results show that the steep slope with a strong support scheme has obvious advantages in land requisition,environmental protection,and safety and is more suitable for reconstructing and expanding the highway slope.

SVEP1 PKHD1 P53在原发性肝癌组织中的表达及其临床意义

目的:使用免疫组化法检测SVEP1、PKHD1与P53在原发性肝癌组织中的表达,结合临床病理因素分析其预测肝癌患者术后复发情况的临床意义。方法:回顾性分析2013年1月至2014年1月于天津医科大学肿瘤医院行手术切除且随访资料完整的103例原发性肝癌患者的临床资料。以ROC曲线为主要统计方法探究不同指标的免疫组化评分对于患者预后的预测效果。根据其临界值将患者分为高危组和低危组,以无瘤生存期主要研究指标比较两组间的差异。结果:患者中位年龄为55(21～88)岁,中位AFP水平70.6(1.03～718 840.0)μg/L,中位CA19-9水平22.89(0.6～1 000.0)kU/L,中位肿瘤大小4.5(1.0～27.0)cm。通过免疫组化法检测SVEP1、PKHD1、P53在原发性肝癌中的表达情况,表达水平使用免疫组化评分进行量化,三个指标免疫组化评分的ROC曲线中AUC面积分别为0.861、0.829、0.716,临界值分别为4、4、1分(P<0.001)。SVEP1高危组(≤4分)与低危组(>4分)3年无瘤生存率分别为4.1%和51.7%;PKHD1高危组(≤4分)与低危组(>4分)3年无瘤生存率分别为5.3%和51.9%;P53高危组(>1分)与低危组(≤1分)3年无瘤生存率分别为6.3%和27.3%,每个指标两组间差异均有统计学意义(P<0.001,<0.001,0.003)。PKHD1与SVEP1联合应用时,其ROC曲线的AUC面积为0.897(P<0.001),敏感性为76.5%,特异性为94.4%。结论:P53预测原发性肝癌复发的准确性不足,不推荐首选使用。SVEP1、PKHD1预测原发性肝癌复发准确性较高,SVEP1特异性较高,PKHD1敏感性较强,两者联用效果更佳。