Fluoroalkyl-containing organic compounds have exhibited wide applications in the field of pharmaceuticals,agrochemicals and materials science due to their outstanding properties such as biological activity,metabolic s...Fluoroalkyl-containing organic compounds have exhibited wide applications in the field of pharmaceuticals,agrochemicals and materials science due to their outstanding properties such as biological activity,metabolic stability,lipophilicity,excellent chemical and thermal stability.Therefore,various synthetic strategies have been developed for the construction of fluoroalkyl-containing compounds,using highly active fluorinating reagents and fluorinated building blocks.Recently,the use of easily available and inexpensive trifluoroacetic anhydride(TFAA)and its anhydride analogues has attracted great attention to access numerous fluoroalkyl-containing compounds through cyclization and coupling reactions.In this review,we summarized the recent advances in the synthesis of fluoroalkylated compounds using fluoroalkyl anhydrides as reagents.This review aims to provide a reference for researchers on how to develop new synthetic straregies of fluorine-containing organic compounds and achieve kilograms or even tons preparation of fluorine-containing organic compounds using fluoroalkyl anhydrides.展开更多
The preparation of heteroaryl trifluoromethyl selenoethers by the trifluoromethylselenolation of heteroaryl bro- mides with [（bpy）CuSeCF3]2 was investigated. Using this approach, a large number of trifluoromethylsel...The preparation of heteroaryl trifluoromethyl selenoethers by the trifluoromethylselenolation of heteroaryl bro- mides with [（bpy）CuSeCF3]2 was investigated. Using this approach, a large number of trifluoromethylselenolated heterocyclic compounds were synthesized in good to excellent yields. It was demonstrated that this procedure toler- ates a wide variety of functional groups.展开更多
A new protocol for the synthesis of diversely substituted 2-trifluoromethyl chromenes from the cyclization reaction of o-isopropenylphenols with trifluoroacetic anhydride has been developed,which proceeds via sequenti...A new protocol for the synthesis of diversely substituted 2-trifluoromethyl chromenes from the cyclization reaction of o-isopropenylphenols with trifluoroacetic anhydride has been developed,which proceeds via sequential trifluoroacetylation and double carbonyl-ene reaction followed by elimination reaction.This methodology exhibits good functional group tolerance,and derivatization of the 2-trifluoromethyl chromene product resulted in other valuable scaffolds.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21772022,and 22171124)Minjiang University(No.MJY21041)Fuzhou University.
文摘Fluoroalkyl-containing organic compounds have exhibited wide applications in the field of pharmaceuticals,agrochemicals and materials science due to their outstanding properties such as biological activity,metabolic stability,lipophilicity,excellent chemical and thermal stability.Therefore,various synthetic strategies have been developed for the construction of fluoroalkyl-containing compounds,using highly active fluorinating reagents and fluorinated building blocks.Recently,the use of easily available and inexpensive trifluoroacetic anhydride(TFAA)and its anhydride analogues has attracted great attention to access numerous fluoroalkyl-containing compounds through cyclization and coupling reactions.In this review,we summarized the recent advances in the synthesis of fluoroalkylated compounds using fluoroalkyl anhydrides as reagents.This review aims to provide a reference for researchers on how to develop new synthetic straregies of fluorine-containing organic compounds and achieve kilograms or even tons preparation of fluorine-containing organic compounds using fluoroalkyl anhydrides.
文摘The preparation of heteroaryl trifluoromethyl selenoethers by the trifluoromethylselenolation of heteroaryl bro- mides with [（bpy）CuSeCF3]2 was investigated. Using this approach, a large number of trifluoromethylselenolated heterocyclic compounds were synthesized in good to excellent yields. It was demonstrated that this procedure toler- ates a wide variety of functional groups.
基金This work was supported by the National Natural Science Foundation of China(21772022),Minjiang University,and Fuzhou University.
文摘A new protocol for the synthesis of diversely substituted 2-trifluoromethyl chromenes from the cyclization reaction of o-isopropenylphenols with trifluoroacetic anhydride has been developed,which proceeds via sequential trifluoroacetylation and double carbonyl-ene reaction followed by elimination reaction.This methodology exhibits good functional group tolerance,and derivatization of the 2-trifluoromethyl chromene product resulted in other valuable scaffolds.
