Bile acids(BAs)are synthesized by the liver from cholesterol through several complementary pathways and aberrant cholesterol metabolism plays pivotal roles in the pathogeneses of cholesterol gallbladder polyps(CGP)and...Bile acids(BAs)are synthesized by the liver from cholesterol through several complementary pathways and aberrant cholesterol metabolism plays pivotal roles in the pathogeneses of cholesterol gallbladder polyps(CGP)and cholesterol gallstones(CGS).To date,there is neither systematic study on BAs profile of CGP or CGS,nor the relationship between them.To explore the metabolomics profile of plasma BAs in healthy volunteers,CGP and CGS patients,an ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)method was developed and validated for simultaneous determination of 42 free and conjugated BAs in human plasma.The developed method was sensitive and reproducible to be applied for the quantification of BAs in the investigation of plasma samples.The results show that,compared to healthy volunteers,CGP and CGS were both characterized by the significant decrease in plasma BAs pool size,furthermore CGP and CGS shared aberrant BAs metabolic characteristics.Chenodeoxycholic acid,glycochenodeoxycholic acid,l-muricholic acid,deoxycholic acid,and 7-ketolithocholic acid were shared potential markers of these two cholesterol gallbladder diseases.Subsequent analysis showed that clinical characteristics including cysteine,ornithine and body mass index might be closely related to metabolisms of certain BA modules.This work provides metabolomic information for the study of gallbladder diseases and analytical methodologies for clinical target analysis and efficacy evaluation related to BAs in medical institutions.展开更多
Nanosized orthorhombic LiMnO2 was successfully synthesized using Mn2O3 and LiOH.H2O as starting materials.Not only the reaction temperature was lower, but the reaction time for synthesizing was notably shortened to 1 ...Nanosized orthorhombic LiMnO2 was successfully synthesized using Mn2O3 and LiOH.H2O as starting materials.Not only the reaction temperature was lower, but the reaction time for synthesizing was notably shortened to 1 h.In this hydrothermal process, the cations of the starting materials were capable of mixing and interacting in ionic scale, which resulted in the rapid formation of o-LiMnO2 powders at relatively low temperature. The particle size conformed by transmission electron microscopy is around 50-150 nm. Benefiting from its small particle size and good uniformity, the obtained o-LiMnO2 can reach the maximum discharge capacity of 163 mA-h.g^-1 at 0.1 C rate after several cycles. X-ray diffraction data and electrochemical properties suggested the phase transformation from orthorhombic LiMnO2 to defect-type spinel LiMn204 with minor Li2MnO3, which resulted in the capacity fading during cycling.展开更多
With the development of the time and the progress of economy,great changes have taken place in the environment.In recent years,it is common to see bad weather,such as hurricane,drought,lightning and so on.The emergenc...With the development of the time and the progress of economy,great changes have taken place in the environment.In recent years,it is common to see bad weather,such as hurricane,drought,lightning and so on.The emergence of these weather has the greatest impact on farmers and crops,especially the lightning weather,not only that,but also sometimes cause personal injury.In face of the frequent occurrence of bad weather in recent years and its harm and threat to China's agriculture,rural areas,personnel,etc.,the author makes a detailed study on the causes of rural lightning weather,analyzes the lightning protection measures in rural areas and their shortcomings,and summarizes the relevant improvement measures.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.:81920108033,and 82274223).
文摘Bile acids(BAs)are synthesized by the liver from cholesterol through several complementary pathways and aberrant cholesterol metabolism plays pivotal roles in the pathogeneses of cholesterol gallbladder polyps(CGP)and cholesterol gallstones(CGS).To date,there is neither systematic study on BAs profile of CGP or CGS,nor the relationship between them.To explore the metabolomics profile of plasma BAs in healthy volunteers,CGP and CGS patients,an ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)method was developed and validated for simultaneous determination of 42 free and conjugated BAs in human plasma.The developed method was sensitive and reproducible to be applied for the quantification of BAs in the investigation of plasma samples.The results show that,compared to healthy volunteers,CGP and CGS were both characterized by the significant decrease in plasma BAs pool size,furthermore CGP and CGS shared aberrant BAs metabolic characteristics.Chenodeoxycholic acid,glycochenodeoxycholic acid,l-muricholic acid,deoxycholic acid,and 7-ketolithocholic acid were shared potential markers of these two cholesterol gallbladder diseases.Subsequent analysis showed that clinical characteristics including cysteine,ornithine and body mass index might be closely related to metabolisms of certain BA modules.This work provides metabolomic information for the study of gallbladder diseases and analytical methodologies for clinical target analysis and efficacy evaluation related to BAs in medical institutions.
基金supported by the National Key R&D Program of China(2017YFB0702800)National Natural Science Foundation of China(21802168,21503280,21603277)China Petrochemical Corporation(Sinopec Group)~~
基金supported by the National Natural Science Foundation of China under grant No.50372058.
文摘Nanosized orthorhombic LiMnO2 was successfully synthesized using Mn2O3 and LiOH.H2O as starting materials.Not only the reaction temperature was lower, but the reaction time for synthesizing was notably shortened to 1 h.In this hydrothermal process, the cations of the starting materials were capable of mixing and interacting in ionic scale, which resulted in the rapid formation of o-LiMnO2 powders at relatively low temperature. The particle size conformed by transmission electron microscopy is around 50-150 nm. Benefiting from its small particle size and good uniformity, the obtained o-LiMnO2 can reach the maximum discharge capacity of 163 mA-h.g^-1 at 0.1 C rate after several cycles. X-ray diffraction data and electrochemical properties suggested the phase transformation from orthorhombic LiMnO2 to defect-type spinel LiMn204 with minor Li2MnO3, which resulted in the capacity fading during cycling.
文摘With the development of the time and the progress of economy,great changes have taken place in the environment.In recent years,it is common to see bad weather,such as hurricane,drought,lightning and so on.The emergence of these weather has the greatest impact on farmers and crops,especially the lightning weather,not only that,but also sometimes cause personal injury.In face of the frequent occurrence of bad weather in recent years and its harm and threat to China's agriculture,rural areas,personnel,etc.,the author makes a detailed study on the causes of rural lightning weather,analyzes the lightning protection measures in rural areas and their shortcomings,and summarizes the relevant improvement measures.
