Dear Editor,Chloroquine(CQ)has long been used as an anti-malarial agent(Wellems and Plowe,2001).Recently,CQ has also been applied to treat viral infection and related diseases(Wellems and Plowe,2001;Huang et al.,2020)...Dear Editor,Chloroquine(CQ)has long been used as an anti-malarial agent(Wellems and Plowe,2001).Recently,CQ has also been applied to treat viral infection and related diseases(Wellems and Plowe,2001;Huang et al.,2020).However,the safety and efficacy of its applications are still under extensive debate(Solomon and Lee,2009).Here,we discovered that low-dose CQ has a geroprotective effect on physiologically aged rats.Low-dose CQ prolonged lifespan,repressed systemic inflammation,and inhibited fibrosis across multiple tissue types in aged rats.Furthermore,we constructed transcriptomic maps for 6 tissues(kidney,small intestine,liver,heart,lung,and aorta)upon CQ treatment,thus revealing the effects of CQ at a systemic level.CQ treatment mitigated age-related molecular changes and repressed genes linked to fibrosis and the inflammatory response.Altogether,our data provide a valuable resource for investigating the impact of CQ on multiple aged tissues,which may facilitate the development of clinical applications that mitigate age-related changes in the elderly.展开更多
基金the National Key Research and Development Program of China(2018YFC2000100)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16000000)+12 种基金the Program of Beijing Municipal Science and Technology Commission(Z191100001519005)the National Natural Science Foundation of China(Grant Nos.81921006,8162500991749202,81861168034,91949209,92049304,81822018,81870228,81922027,82071588,92049116,31801010,81901433,82125011,82122024,92149301,92168201)the National Key Research and Development Program of China(2020YFA0804000,2020YFA0112200,2017YFA0103304,2017YFA0102802,2018YFA0107203,2020YFA0113400)the Program of the Beijing Natural Science Foundation(Z190019,JQ20031)the Key Research Program of the Chinese Academy of Sciences(KFZDSW-221)K.C.Wong Education Foundation(GJTD-2019-06,GJTD-2019-08)Beijing Hospitals Authority Youth Programme(QML20200802)Youth Innovation Promotion Association of CAS(E1CAZW0401,2021078)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020-JKCS-011)the State Key Laboratory of Stem Cell and Reproductive Biology,the State Key Laboratory of Membrane Biology,the 14th Five-year Network Security and Informatization Plan of Chinese Academy of Sciences(WX145XQ07-18)the Informatization Plan of Chinese Academy of Sciences(CAS-WX2021SF-0301)the Milky Way Research Foundation(MWRF),Young Elite Scientists Sponsorship Program by CAST(NO.YESS20200012)CAS Project for Young Scientists in Basic Research(YSBR-012)and the Tencent Foundation.
文摘Dear Editor,Chloroquine(CQ)has long been used as an anti-malarial agent(Wellems and Plowe,2001).Recently,CQ has also been applied to treat viral infection and related diseases(Wellems and Plowe,2001;Huang et al.,2020).However,the safety and efficacy of its applications are still under extensive debate(Solomon and Lee,2009).Here,we discovered that low-dose CQ has a geroprotective effect on physiologically aged rats.Low-dose CQ prolonged lifespan,repressed systemic inflammation,and inhibited fibrosis across multiple tissue types in aged rats.Furthermore,we constructed transcriptomic maps for 6 tissues(kidney,small intestine,liver,heart,lung,and aorta)upon CQ treatment,thus revealing the effects of CQ at a systemic level.CQ treatment mitigated age-related molecular changes and repressed genes linked to fibrosis and the inflammatory response.Altogether,our data provide a valuable resource for investigating the impact of CQ on multiple aged tissues,which may facilitate the development of clinical applications that mitigate age-related changes in the elderly.
