Glycogen storage disease(GSD)is a rare autosomal recessive disease by abnormal accumulation of intracellular glycogen.1 Mutations in genes encoding G-6-P or G-6-Pase lead to dysfunction of the body's glycogen meta...Glycogen storage disease(GSD)is a rare autosomal recessive disease by abnormal accumulation of intracellular glycogen.1 Mutations in genes encoding G-6-P or G-6-Pase lead to dysfunction of the body's glycogen metabolism.Without adequate metabolic treatment,patients with GSD can die during infancy or childhood from severe hypoglycemia and acidosis.The patient's symptoms generally achieve remission during adolescence,except in rare cases when cirrhosis of the liver or myopathy occurs.Once GSD is identified in adults,the patients are often accompanied by many complications,such as fasting hypoglycemia.展开更多
To the Editor,Hepatocellular carcinoma(HCC)is a malignant tumor with the fourth highest incidence and the third highest mortality among all tumor sites in China.1 Finding new diagnostic markers and therapeutic molecul...To the Editor,Hepatocellular carcinoma(HCC)is a malignant tumor with the fourth highest incidence and the third highest mortality among all tumor sites in China.1 Finding new diagnostic markers and therapeutic molecules may be of great value in the treatment of HCC and the improvement of prognosis.展开更多
基金supported by the National Natural Science Foundation of China(NSFC,No.81702407/H1617)Fundamental Research Funds for the Central Universities of Ministry of Education of China(No.2042017kf0054)the Hubei Chenguang Talented Youth Development Foundation(HBCG),China.
文摘Glycogen storage disease(GSD)is a rare autosomal recessive disease by abnormal accumulation of intracellular glycogen.1 Mutations in genes encoding G-6-P or G-6-Pase lead to dysfunction of the body's glycogen metabolism.Without adequate metabolic treatment,patients with GSD can die during infancy or childhood from severe hypoglycemia and acidosis.The patient's symptoms generally achieve remission during adolescence,except in rare cases when cirrhosis of the liver or myopathy occurs.Once GSD is identified in adults,the patients are often accompanied by many complications,such as fasting hypoglycemia.
基金This work was supported by grants from the National Natural Science Foundation of China(No.81872029 and 81772926).
文摘To the Editor,Hepatocellular carcinoma(HCC)is a malignant tumor with the fourth highest incidence and the third highest mortality among all tumor sites in China.1 Finding new diagnostic markers and therapeutic molecules may be of great value in the treatment of HCC and the improvement of prognosis.
