Expression of FOXG1 is associated with the malignancy of human glioma

Objective： Recent evidence indicates that the increased expression of FOXG1 is associated with tumor genesis. This study was designed to explore the expression and role which FOXG1 plays in human glioma. Methods： We detected the expression of FOXG1 by immunohistochemistry in glioma tissue samples. Following the down-regulation of FOXG1 in glioma cell lines by a specific short hairpin RNA, the function of FOXG1 in proliferation and apoptosis was assessed. Results： Glioma tissues exhibited notably higher expression of FOXG1 compared with control brain tissues and was positively corre- lated with histological malignancy. The down-regulation of FOXG1 in glioma cells led to a cell apoptosis in vitro. Cenclusion： The overexpression of FOXG1 is a novel glioma malignancy marker, and FOXG1 may be used as a new target in therapeutic strategies for human glioma.

Numerically investigating the crushing of sandstone by a tooth hob

To investigate the mechanical process that occurs between rocks and tooth hobs,the crushing of sandstone with a tooth hob was simulated using reconstructed multi-mineral mesoscopic numerical models of various grain-sized sandstone samples.When a piece of sandstone is crushed by the tooth of a hob rolling at a constant speed,the resultant reaction forces of the sandstone on the tooth first hinder and then contribute to the rolling of the hob.The absolute value of the longitudinal reaction force is significantly higher than that of the lateral reaction force.Because the tooth was subjected to reaction forces from the sandstone,forces and moments were applied to the hob in order to keep the hob rolling.The applied forces were equal in value and opposite in direction to the reaction forces of the sandstone on the tooth.Three typical curves of the work done by the applied forces and moment were obtained,and the contribution of the applied lateral force and moment to the total work done for crushing sandstones was variable;however,no work was done by the applied longitudinal force.Moreover,the applied longitudinal force and total work were positively correlated with the strength of sandstone samples.The total work,applied forces,and moment increased with the maximum penetration depth of the tooth in the sandstone.

Influence of construction-induced damage on the degradation of freeze—thawed lightweight cellular concrete

During the construction of lightweight cellular concrete(LCC),material damage frequently occurs,causing the degradation and deterioration of the mechanical performance,durability,and subgrade quality of LCC.The construction-induced damage can be more significant than those from the service environment of LCC,such as freeze-thaw(F-T)action in cold regions.However,the effect of construction-induced damage on LCC during F-T cycles is often ignored and the deterioration mechanisms are not yet clarified.In this study,we investigated the factors causing damage during construction using a sample preparation method established to simulate the damage in the laboratory setting.We conducted F-T cycle tests and microstructural characterization to study the effect of microstructural damage on the overall strength of LCC with different water contents under F-T actions.We established the relationship between the pore-area ratio and F-T cycle times,pore-area ratio,and strength,as well as the F-T cycle times and strength under different damage forms.The damage evolution is provided with the rationality of the damage equation,verified by comparing the measured and predicted damage variables.This study would serve as a guide for the construction and performance of LCC in cold regions.

Quality evaluation of lightweight cellular concrete by an ultrasound-based method

The accuracy of subgrade quality evaluation is important for road safety assessment.Since there is little research work devoted to testing lightweight cellular concrete(LCC)by an ultrasound-based method,the quantitative relation between ultrasonic testing results and the quality of LCC subgrade is not well understood.In this paper,the quality of LCC subgrade was evaluated with respect to compressive strength and crack discrimination.The relation between ultrasonic testing results and LCC quality was explored through indoor tests.Based on the quantitative relation between ultrasonic pulse velocity and compressive strength of LCC,a fitting formula was established.Moreover,after the LCC became cracked,the ultrasonic pulse velocity and ultrasonic pulse amplitude decreased.After determining the lower limiting values of the ultrasonic pulse velocity and ultrasonic pulse amplitude through the statistical data,it could be calculated whether there were cracks in LCC subgrade.The ultrasonic testing results showed that the compressive strength of the LCC subgrade was suitable for purpose and there was no crack in the subgrade.Then core samples were taken from the subgrade.Comparisons between ultrasonic testing results of subgrade and test results of core samples demonstrated a good agreement.