Wide frequency phonons manipulation in Si nanowire by introducing nanopillars and nanoparticles

The combination of different nanostructures can hinder phonons transmission in a wide frequency range and further reduce the thermal conductivity(TC).This will benefit the improvement and application of thermoelectric conversion,insulating materials and thermal barrier coatings,etc.In this work,the effects of nanopillars and Ge nanoparticles(GNPs)on the thermal transport of Si nanowire(SN)are investigated by nonequilibrium molecular dynamics(NEMD)simulation.By analyzing phonons transport behaviors,it is confirmed that the introduction of nanopillars leads to the occurrence of lowfrequency phonons resonance,and nanoparticles enhance high-frequency phonons interface scattering and localization.The results show that phonons transport in the whole frequency range can be strongly hindered by the simultaneous introduction of nanopillars and nanoparticles.In addition,the effects of system length,temperature,sizes and numbers of nanoparticles on the TC are investigated.Our work provides useful insights into the effective regulation of the TC of nanomaterials.

奥曲肽与乌司他丁联合治疗急性胰腺炎的临床效果观察

目的探讨奥曲肽与乌司他丁联合治疗急性胰腺炎的临床效果。方法选取2014年7月-2016年12月我院收治的118例急性胰腺炎患者,将其分为研究组和对照组,各59例,对照组患者予以单用奥曲肽治疗,研究组患者采用乌司他丁联合奥曲肽治疗,并比较不同组患者临床效果。结果研究组患者总有效率明显高于对照组(P<0.05);治疗前,研究组和对照组患者血尿淀粉酶相比差异不明显(P>0.05),但治疗后,研究组和对照组患者血尿淀粉酶均明显改善(P<0.05),研究组患者改善更为明显(P<0.05);研究组患者腹胀和腹痛缓解时间以及住院时间均明显优于对照组,差异有统计学意义(P<0.05)。结论乌司他丁联合奥曲肽在治疗急性胰腺炎方面临床疗效确切,不仅能改善患者临床症状,同时还能缩短住院时间。

Chromatic processing for feature extraction of PD-induced UHF signals in GIS

Partial discharge(PD) detection is an effective means of discovering insulation faults in gas-insulated switchgear(GIS). One of the most extensively used methods in PD detection has historically been the ultrahigh frequency(UHF) method. This study evaluates the chromatic processing methodology and its key factors for feature extraction of UHF signals in GIS. Three types of artificial defects are installed in the GIS tank at 0°, 90°, and 180°, respectively. The features of the UHF signals are extracted in the chromatic space, and PD discrimination of the defects is achieved. The influences of processors are studied before the feature selections are suggested. The time-stepping method is proposed to determine the rules of UHF signal frequency characteristics that vary with time. Finally, the process and options of the chromatics-inspired methodology are summarized.

Laparoscopic ureterolysis with simultaneous ureteroscopy and percutaneous nephroscopy for treating complex ureteral obstruction after failed endoscopic intervention:A technical report

Objective:Complex ureteral obstruction is refractory to conventional urological intervention.This report describes a case of laparoscopic ureterolysis with simultaneous ureteroscopy and percutaneous nephroscopy for treating complex ureteral obstruction.Methods:Right-side multiple ureteral stones and complicating ureteral obstruction failed an initial attempt of ureteroscopy lithotripsy with simultaneous percutaneous nephroscopy in a 23-year-old male.Laparoscopic ureterolysis with ureteroscopy and percutaneous nephroscopy was used simultaneously to dissect the periureteral adhesions with the patient placed in the Galdakao-modified supine Valdivia position.The ureter was incised to allow the insertion of a ureteral catheter through the twisted ureter,and a guide wire was advanced into the pelvis using ureteroscopy.A double-J stent was placed into the right-side ureter using antegrade percutaneous nephroscopy.Results:The laparoendoscopic procedure lasted 330 min with an estimated bleeding volume of 100 mL.The patient underwent an uneventful postoperative course,and postoperative followup radiography confirmed good positioning of the double-J stent.The double-J stent was removed 3 months after operation.The patient remained asymptomatic within a 13-month follow-up period.Conclusion:Laparoscopic ureterolysis with simultaneous ureteroscopy and percutaneous nephroscopy is an effective and safe treatment option for complex ureteral obstruction.

Effect of Combined Application of Humic Acid and Urea on the Wheat Growth and Yield

This paper aims to research the effects of combined application of humic acid and urea on the wheat yield and yield component,and establish rational fertilizer application scheme of wheat. Split plot experiment was adopted. Two types of phosphorus fertilizer( adding humic acid or not) was assigned to the main plot,and four types of top dressing modes( different amount of urea and humic acid urea) were used in subplots. Effects of combined application of humic acid and urea on the wheat yield and yield component were researched. 375 kg / ha ordinary DAP + 150 kg / ha urea was used as base fertilizer; topdressing of 300 kg / ha urea humate could effectively promote the plant height,leaf area coefficient and aboveground dry matter amount. Adding humic acid in urea in topdressing significantly enhanced the wheat yield and economic coefficient of wheat. Adding humic acid in urea in topdressing has better effects of yield increasing than base fertilizer,and can be used for large scale extension.

Charge transfer complex enabled photoreduction of ether phosphonium salts for the selective oxyalkylation of enamides

A charge transfer complex(CTC)-enabled photoreduction of ether phosphonium salts for the generation of oxyalkyl radicals was described.The photoreduction provides a convenient method to achieve selective oxyalkylation of enamides with broad substrate scope.The method features operational simplicity,mild and inherent green conditions.

Highly sensitive fluorescent sensing and photocatalytic degradation performance of two-dimensional Tb-organic network

A novel tetra-nuclear Tb-organic network,named as [Tb_(4)(2-pyia)_(6)(HAc)_(0.5)(2,2'-bipy)(H_(2)O)_(4.5)]·2,2'-bipy·H_(2)O(1),was synthesized hydrothermally based on 5-(pyridin-2-ylmethoxy) isophthalic acid(H_(2)pyia) and 2,2'-bipyridine(2,2'-bipy) ligands,and characterized by single crystal X-ray diffraction,thermogravimetric(TG) analyses,powder X-ray diffraction(PXRD) and infrared(IR) technology.1 possesses a two-dimensional network based on the tetra-nuclear inorganic building units,and the π-πstacking interactions between the pyia^(2-) ligands and the guest 2,2'-bipy molecules play an important role in the forming of 3D supramolecular structure.1 exhibits excellent fluorescent sensing performance for Fe^(3+)(1.26×10^(-8) mol/L),Cr_(2)O_(7)^(2-)(8.1×10^(-7) mol/L),2,4,6-trinitrophenol(TNP)(2.71×10^(-8) mol/L)and tetracycline(TCT)(2.76×10^(-7) mol/L) in aqueous solution with lower detection concentrations.The sensing mechanisms of 1 were investigated by density functional theory(DFT) calculations,ultraviolet-visible(UV-Vis) diffuse reflectance spectroscopy,PXRD and fluorescent lifetime analyses.The activated product of 1 was prepared by heating at 255℃ under constant pressure and used to photo-catalytically degrade TCT.Both 1 and the activated one have good photocatalytic degradation performance for TCT with degradation rates of 84.29% and 96.07%,respectively.The photocatalytic mechanisms were discovered by UV-Vis diffuse reflectance spectroscopy and radical trap experiments.The Tb-organic framework might be an excellent multifunctional fluorescent sensor and a good photocatalytic agent for TCT degradation in the future.

Generative pretrained transformer 4:an innovative approach to facilitate value-based healthcare

Objective Appropriate medical imaging is important for value-based care.We aim to evaluate the performance of generative pretrained transformer 4(GPT-4),an innovative natural language processing model,providing appropriate medical imaging automatically in different clinical scenarios.Methods Institutional Review Boards(IRB)approval was not required due to the use of nonidentifiable data.Instead,we used 112 questions from the American College of Radiology(ACR)Radiology-TEACHES Program as prompts,which is an open-sourced question and answer program to guide appropriate medical imaging.We included 69 free-text case vignettes and 43 simplified cases.For the performance evaluation of GPT-4 and GPT-3.5,we considered the recommendations of ACR guidelines as the gold standard,and then three radiologists analyzed the consistency of the responses from the GPT models with those of the ACR.We set a five-score criterion for the evaluation of the consistency.A paired t-test was applied to assess the statistical significance of the findings.Results For the performance of the GPT models in free-text case vignettes,the accuracy of GPT-4 was 92.9%,whereas the accuracy of GPT-3.5 was just 78.3%.GPT-4 can provide more appropriate suggestions to reduce the overutilization of medical imaging than GPT-3.5(t=3.429,P=0.001).For the performance of the GPT models in simplified scenarios,the accuracy of GPT-4 and GPT-3.5 was 66.5%and 60.0%,respectively.The differences were not statistically significant(t=1.858,P=0.070).GPT-4 was characterized by longer reaction times(27.1 s in average)and extensive responses(137.1 words on average)than GPT-3.5.Conclusion As an advanced tool for improving value-based healthcare in clinics,GPT-4 may guide appropriate medical imaging accurately and efficiently。

Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study

Sorafenib therapy improves overall survival(OS)in patients with FLT3 internal tandem duplication(ITD)acute myeloid leukemia(AML)undergoing allogeneic hematopoietic stem cell transplantation.We explored the efficacy of sorafenib therapy in this population with different concomitant genetic patterns.In this multi-center,cohort study,we enrolled patients with FLT3-ITD AML undergoing allogenic hematopoietic cell transplantation.Patients with sorafenib maintenance post-transplantation for at least four weeks were allocated to the sorafenib group,and otherwise to the control group.

Orbital and Millennial-Scale Climate Variability over the Past 76 ka in the Western Tarim Basin, Northwest China

Paleoclimate changes during the last glacial in the arid central Asia are not as well understood as the monsoon-dominated areas of Asia. Here we report a 75-m-long sediment core over past 120 kyr based on astronomical tuning combined with the optically stimulated luminescence(OSL) dating in the Kashi depression of the western Tarim Basin, Northwest China. Analysis of grain size and highresolution gamma ray(GR) logs from the KT11 borehole across the last glacial period yields a climate history for the Tarim Basin which reflects the variations of its temperature and the hydrological cycles. Comparison of these records with north hemisphere summer insolation, the Greenland ice core temperature, stalagmites and the loess from the nearby region indicates that the deposits in the fluvio-lacustrine system of the Kashi depression responded to climate change at the Younger Dryas(YD), six Heinrich cooling events and the Dansgaard-Oeschger cycles. Our work indicates that the alternations between warm-humid and cold-dry climates were prevalent in the western Tarim Basin during the last glacial period, showing an in-phase pattern with the climate variations of the East Asian Monsoon, controlled ultimately by precession and North Atlantic Ocean climate variability on orbital-millennial time scales.

Aryldiazonium salts can serve as nitrogen-based Lewis acid catalysts and their applications in the formation of photoactive charge transfer complexes

We report the Lewis acid catalysis of aryldiazonium salts,and their Lewis acidity applications in photogeneration of aryl radicals under additive-,photocatalyst-and transition metal-free conditions.In this visible light-mediated transformation,the Lewis acidic character of aryldiazonium salts enables access to the photoactive charge transfer complex with dichalcogenides.The usefulness and versatility of this new protocol are demonstrated through the chalcogenation of a variety of aryldiazonium salts.

Visible-light-induced direct hydrodifluoromethylation of alkenes with difluoromethyltriphenylphosphonium iodide salt

Photoredox-catalyzed hydrodifluoromethylation of alkenes has become an effective method to introduce difluoromethyl group into organic molecules.As the reported methods involve either photocatalysts or superstoichiometric amounts of additives,we herein describe a simple alternative without using photocatalyst or additive for the hydrodifluoromethylation of alkenes,through photoactivation of difluoromethyltriphenylphosphonium iodide salt.Mechanistic studies shed light on how the transformation takes place.

Fermented soybean meal improves the growth performance, nutrient digestibility, and microbial flora in piglets

In order to increase nutritive values of soybean meal(SBM), 3 species of microbes were used to ferment SBM. Through a 3 x 3 orthogonal design and parameter measurements of soybean peptide and antinutritional factor contents in the fermented soybean meal(FSBM), it was estimated that the best microbial proportion of Bacillus subtilis, Hansenula anomala and Lactobacillus casei was 2:1:2 for SBM fermentation(P < 0.05). The further piglet feeding experiment showed that 10% FSBM substitute for SBM had no significant effect on growth performance of suckling piglets(d 7-28)(P> 0.05). However, newlyweaned piglets(d 28-38) fed 10% FSBM and different levels of plasma protein obtained higher average daily gain(ADG) and feed conversion ratio(FCR), compared with those without FSBM but with 6% plasma protein(P < 0.05). Piglets(d 38-68) fed diets supplemented with FSBM and soybean protein concentrate(SBPC) at 3.75% and 7.5% respectively increased nutrient digestibility,fecal enzyme activity and lactic acid bacteria counts, and decreased fecal Escherichia coli counts(P < 0.05), compared with the control. These data indicated that FSBM had positive effects on nutrient digestibility and fecal microflora for piglets.

Astronomical time scale for the lower Doushantuo Formation of early Ediacaran,South China

Nearly 90% of the Ediacaran Period(635–541 Ma) of the Neoproterozoic is represented by the Doushantuo Formation(DST Fm) in South China.Its lowest Member I is a 3.7 m-thick cap carbonate deposited at the termination of the Cryogenian Marinoan glaciation.The DST Fm consists of alternating organic-rich black shale and thinly bedded dolostone, and it contains some of the oldest records of multicellular life and three pronounced negative carbon isotope excursions.The Jiulongwan(JLW) section is a well-studied reference section for these Ediacaran events.Spectral analysis of geochemical data through the lower DST Fm(22.3 m) shows 27 predominant ～90 cm sedimentary cycles that correspond to 405-ka long eccentricity cycles.The power spectra of the 405-ka tuned Ca and Fe/Ti series show significant peaks at ～1.2-Ma, 405-ka, 133-ka, 128-ka, 100-ka, 82-ka, ～31-ka and 29-ka periods, respectively.A 11.16 Malong astronomical time scale has been constructed for the lower DST Fm and provide a duration of 1.6 Ma for the cap carbonate(Member Ⅰ) based on the 405-ka long eccentricity cycle tuning.Using the U-Pb age of 635.2 ± 0.6 Ma for the volcanic ash bed at the Member Ⅰ/Ⅱboundary, we proposed a 636.8 Ma age for the base of the DST Fm.These ages and astronomical timescale provide important new constraints on the subdivision of Ediacaran strata, and have implications for understanding the character of the first negative δ^(13)C excursion(EN1).Orbital forcing may have been played an important role for the climate changes and the evolution of Ediacaran multi-cellular life and the carbon cycle variations.

On growth performance, nutrient digestibility, blood T lymphocyte subsets, and cardiac antioxidant status of broilers

Different lipid sources differ in the fatty acid profiles and differently affect growth performance as well as immune function of broilers. The influences of different dietary lipid sources on growth performance, nutrient digestibility, blood T lymphocyte population, and cardiac antioxidant status were investigated of broilers. A total of 360 one-day-old male broilers(BW = 44 ± 3 g) were randomized into 3 treatment groups, consisting of 6 replicates with 20 birds in each group. Broilers received standard diets supplemented with 5%(wt/wt) of lard(LD, as a control diet), sesame oil(SO), or flaxseed oil(FO).Broilers in both SO and FO treatment groups had lower(P < 0.05) feed conversion ratios from 22 to 42 d and during the overall phase compared to those in LD treatment group. Meanwhile, the apparent total tract nutrient digestibility of crude fat in SO and FO treatment groups was higher than that in LD treatment group. Both FO and SO treatments decreased(P < 0.05) abdominal fat percentage compared to LD treatment. Total triglycerides and total cholesterol in chicken blood were decreased(P < 0.05) by SO and FO treatments compared to LD treatment. Feeding broilers with FO and SO led to a decrease(P < 0.05) in blood CD4^+ T lymphocyte count and in CD4^+:CD8^+ ratio compared to LD treatment.Sesame oil and FO treatments increased cardiac glutathione peroxidase(P < 0.05) compared to LD treatment. It is concluded that addition of 5% SO and FO to the standard corn-soybean meal diet improved feed efficiency, increased the activities of cardiac glutathione peroxidase, and affected the T lymphocytes ratio of fast growing broilers.

Visible-light-induced N-heterocyclic carbene mediated cascade transformation of N-alkenoxypyridinium salts

While N-alkenoxypyridinium salts are widely used for the synthesis ofα-functionalized ketones via umpolung strategy,such approaches are usually limited to special nucleophiles at high temperatures.Herein,we developed an alternative photoinduced N-heterocyclic carbene(NHC)-mediated functionalization of N-alkenoxypyridinium salts with various nucleophiles,including tetramethylammonium azide,secondary amines,aryl and alkyl thiols,and even the challenging C(sp^(3))-nucleophiles,under mild conditions.A cascade radical-radical coupling/nucleophilic substitution sequence was proposed,wherein the NHC enabled the formation of a photoactive electron donor-acceptor complex forα-iodo ketone synthesis.

“套路嫖”行为的定性——以杭州首例“套路嫖”案判决为切入点的思考

对于“套路嫖”行为定性问题的争议,主要在于该类行为是民事欺诈行为还是刑事诈骗行为。民事欺诈行为和刑事诈骗行为在客观方面具有较大的相似性,很难依据行为的客观表现将二者进行区分。回归到诈骗罪的构成要件,可以看到,诈骗罪的成立要求行为人主观上除了需要具备欺骗的故意之外还需要具备非法占有目的,而民事欺诈行为的成立并不要求行为人具有非法占有目的。从是否要求行为人具有非法占有目的上来看,民事欺诈与刑事诈骗之间存在着明显的互斥关系。非法占有目的是区分民事欺诈和刑事诈骗的关键点,实践中可以结合欺骗内容,被害人交易目的,行为人事前、事中、事后的表现及行为结果对非法占有目的进行认定。“套路嫖”行为属于诈骗行为,应当以诈骗罪定罪处罚。