Induced pluripotent stem cell(iPSC)technology is one of the de novo approaches in regeneration medicine and has led to new research applications for wound healing in recent years.Fibroblasts have attracted wide attent...Induced pluripotent stem cell(iPSC)technology is one of the de novo approaches in regeneration medicine and has led to new research applications for wound healing in recent years.Fibroblasts have attracted wide attention as the first cell line used for differentiation into iPSCs.Researchers have found that fibroblasts can be induced into different types of cells in variable mediums or microenvironments.This indicates the potential“stem”characteristics of fibroblasts in terms of direct cellular reprogramming compared with the iPSC detour.In this review,we described the morphology and biological function of fibroblasts.The stem cell characteristics and activities of fibroblasts,including transdifferentiation into myofibroblasts,osteogenic cells,chondrogenic cells,neurons,and vascular tissue,are discussed.The biological values of fibroblasts are then briefly reviewed.Finally,we discussed the potential applications of fibroblasts in clinical practice.展开更多
基金The Creation and Innovation Project of Jilin Province,Grant/Award Number:2022C043‐11Shenzhen Healthcare Research Project,Grant/Award Number:201505018+1 种基金The Science and Technology Project of Jilin Province,Grant/Award Number:20210203079SFThe Health Technology Promotion Project of Jilin Province,Grant/Award Number:2022JC001。
文摘Induced pluripotent stem cell(iPSC)technology is one of the de novo approaches in regeneration medicine and has led to new research applications for wound healing in recent years.Fibroblasts have attracted wide attention as the first cell line used for differentiation into iPSCs.Researchers have found that fibroblasts can be induced into different types of cells in variable mediums or microenvironments.This indicates the potential“stem”characteristics of fibroblasts in terms of direct cellular reprogramming compared with the iPSC detour.In this review,we described the morphology and biological function of fibroblasts.The stem cell characteristics and activities of fibroblasts,including transdifferentiation into myofibroblasts,osteogenic cells,chondrogenic cells,neurons,and vascular tissue,are discussed.The biological values of fibroblasts are then briefly reviewed.Finally,we discussed the potential applications of fibroblasts in clinical practice.
