Ligaments are densely connective soft tissues capable of maintaining stability and function of knee joint.As an important factor,the constitutive relation of ligament would affect its biomechanics and further play an ...Ligaments are densely connective soft tissues capable of maintaining stability and function of knee joint.As an important factor,the constitutive relation of ligament would affect its biomechanics and further play an essential role in the research on ligament injury,healing and treatment.The objective of this paper is to provide an overview of the current research on ligament constitutive relations on the macro,meso,and micro levels as well as the anatomy and histological structure of ligament.Some studies of biomechanical behaviors during ligament injury and healing periods have also been investigated.Based on the research on ligament constitutive relation in the past three decades,a discussion of some research perspectives is also presented,such as a validated accurate measuring method of in situ strain in ligament,a new constitutive relation involving the distribution of ultra-structural properties,and a rational estimation of ligament injury and healing process by the change of its ultra-structural or histological characteristics.展开更多
Cell adhesion plays an important role in cell physiology. A better understanding of this process could facilitate many clinical therapies. In this study, Rat bone marrow-derived mesenchymal stem cells （rBMSCs） were ...Cell adhesion plays an important role in cell physiology. A better understanding of this process could facilitate many clinical therapies. In this study, Rat bone marrow-derived mesenchymal stem cells （rBMSCs） were cultured on glass substrate, and the morphology and adhesion strength were characterized. The cell morphology was defined as spherical, adhesive, and spreading. The adhesion strengths of the different morphologies exhibited different distribu- tion patterns. The spherical cells exhibited low adhesion strength; the adhesive cells exhibited rapidly increasing adhesion strength while their diameters remained relatively constant. The ad- hesion strength increased with the cell diameter in the spreading cells. These findings suggest that adhesion strength can be quickly assessed by examining the cell morphology.展开更多
基金supported by the National Natural Science Foundation of China(No.51275267)
文摘Ligaments are densely connective soft tissues capable of maintaining stability and function of knee joint.As an important factor,the constitutive relation of ligament would affect its biomechanics and further play an essential role in the research on ligament injury,healing and treatment.The objective of this paper is to provide an overview of the current research on ligament constitutive relations on the macro,meso,and micro levels as well as the anatomy and histological structure of ligament.Some studies of biomechanical behaviors during ligament injury and healing periods have also been investigated.Based on the research on ligament constitutive relation in the past three decades,a discussion of some research perspectives is also presented,such as a validated accurate measuring method of in situ strain in ligament,a new constitutive relation involving the distribution of ultra-structural properties,and a rational estimation of ligament injury and healing process by the change of its ultra-structural or histological characteristics.
基金financial support received from the Sate Key Laboratory of Tribology, Tsinghua University
文摘Cell adhesion plays an important role in cell physiology. A better understanding of this process could facilitate many clinical therapies. In this study, Rat bone marrow-derived mesenchymal stem cells （rBMSCs） were cultured on glass substrate, and the morphology and adhesion strength were characterized. The cell morphology was defined as spherical, adhesive, and spreading. The adhesion strengths of the different morphologies exhibited different distribu- tion patterns. The spherical cells exhibited low adhesion strength; the adhesive cells exhibited rapidly increasing adhesion strength while their diameters remained relatively constant. The ad- hesion strength increased with the cell diameter in the spreading cells. These findings suggest that adhesion strength can be quickly assessed by examining the cell morphology.
