THE VALUE DISTRIBUTION OF GAUSS MAPS OF IMMERSED HARMONIC SURFACES WITH RAMIFICATION

Motivated by the result of Chen-Liu-Ru[1],we investigate the value distribution properties for the generalized Gauss maps of weakly complete harmonic surfaces immersed in R^(n) with ramification,which can be seen as a generalization of the results in the case of the minimal surfaces.In addition,we give an estimate of the Gauss curvature for the K-quasiconfomal harmonic surfaces whose generalized Gauss map is ramified over a set of hyperplanes.

Analysis of correlation between MSCT classification and prognosis of basal ganglia hypertensive intracerebral hemorrhage

Objective:To investigate the correlation between MSCT grading and the prognosis of basal ganglia hypertensive intracerebral hemorrhage.Methods:A total of 86 patients with basal ganglia hypertensive cerebral hemorrhage admitted to our hospital from May 2017 to March 2018 were selected.The clinical data and imaging data were collected from 86 patients.The MSCT images were observed and summarized by two radiologists.Based on the morphology of cisterna ambiens and brain stem,the correlation of MSCT grading to Glasgow Coma Scale(GCS)and Glasgow Outcome Scale(GOS)grading was analyzed by use of Spearman correlation analysis.Results:Among 86 patients,the number of MSCT gradeⅠ,Ⅱ,ⅢandⅣwere 29 cases,38 cases,9 cases and 10 cases respectively.There was no significant correlation between MSCT grading and age,sex as well as types of combined underlying diseases in the patients with basal ganglia hypertensive intracerebral hemorrhage(p>0.05).Spearman correlation analysis showed that there was a positive correlation between MSCT grading and GCS score of basal ganglia hypertensive intracerebral hemorrhage.The higher MSCT grade was,the higher GCS score was(r=0.719,p<0.001).There was a positive correlation between MSCT grading and GOS grading of basal ganglia hypertensive intracerebral hemorrhage.The higher MSCT grade was,the higher GOS grade was,leading to a poor prognosis(r=0.734,p<0.001).86 cases of basal ganglia hypertensive intracerebral hemorrhage showed round or quasi-circular high-density shadows in MSCT images,the CT value ranged from 50 Hu to 80 Hu.Low-density bands surrounded the hematoma in the acute stage,and space-occupying effect could be seen in some patients,which resulted in the compression of ventricular sulcus and cistern and the displacement of midline structure.Subacute basal ganglia hypertensive intracerebral hemorrhage patients showed a relative decrease in the density of hematoma,with the extent of edema gradually reduced,the focus showed a high-density shadow in the center;chronic basal ganglia hypertensive intracerebral hemorrhage focus showed a cystic low-density shadow.Conclusion:MSCT grading of basal ganglia hypertensive intracerebral hemorrhage is positively correlated to GCS and GOS grading.MSCT grading can contribute to the prognostic evaluation to the patients.

Luminescent terphen[3]arene sulfate-activated FRET assemblies for cell imaging

Multicharged supramolecular assemblies based on luminescent macrocycle play an important role in extending their optical properties and functions.Herein,we reported macrocyclic supramolecular assemblies based on luminescent terphen[3]arene sulfate(TP[3]AS)and tetraphenylethylene pyridinium(TPE-4Py)through electrostatic interactions,host-guest encapsulation andπ-πstacking interactions.F?rster resonance energy transfer(FRET)process from TP[3]AS to TPE-4Py was achieved with the energy transfer efficiency of 99.9%,accompanied by TPE-4Py fluorescence emission bathochromic shifted of 15 nm and enhanced by 1.68 times in PBS solution.In contrast,other non-luminescent sulfato-β-cyclodextrin and sulfobutylether-β-cyclodextrin only can enhance the fluorescence intensity of TPE-4Py without bathochromic shift.Due to the strong fluorescence and good stability of TPE-4Py@TP[3]AS,it can be used for optical imaging in living cells,which provided an effective approach for the construction of assembling-confined luminescent biomaterials.

氨基酸修饰β-环糊精对胆酸分子键合的热力学性质及生物应用

环糊精对客体分子的选择键合是当今超分子化学的研究热点之一.其中,环糊精衍生物对胆酸类分子的键合行为及热力学性质研究对于理解主-客体识别机理及热力学起源具有重要的科学意义.本文主要综述了甘氨基、色氨酸、酪氨酸及其脱羧衍生物修饰的β-环糊精对几种典型胆酸分子的识别,包括胆酸(CA)、脱氧胆酸(DCA)、鹅去氧胆酸(CDCA)、甘胆酸(GCA)及牛黄胆酸(TCA)的键合模式、键合能力、分子选择性以及热力学起源,尤其是在清除体内胆酸、调控胆酸平衡、治疗疾病方面的应用.这些研究对于进一步深入理解主客体相互作用的识别机理以及推动超分子化学的发展都具有重要的作用.

Fluorescence Sensing of Glutathione Thiyl Radical by BODIPY-Modified β-Cyclodextrin

Comprehensive Summary The fluorescence sensing of intracellular glutathione thiyl radical(GS·)is in great demand to seek the GS·-related pathophysiological events.Herein,boron-dipyrromethene(BODIPY)-modified β-cyclodextrin was developed for high-efficiency sensing of GS·,accompanied by a fast response time(t_(1/2)=218 s),with the detection limit of 468 nmol/L.Cell experiments indicated that the BODIPY-modified p-cyclodextrin could be applied to detect the GS· in live A549 cells.

Organic supramolecular aggregates based on water-soluble cyclodextrins and calixarenes

Macrocycle-induced formation of pure organic supramolecular aggregates is a challenge that has attracted considerable attention from researchers in the fields of chemistry,biology,and materials science.In particular,aggregation induced by water-soluble cyclodextrins and calixarenes,which are two classic of macrocycles with a hydrophobic cavity and a hydrophilic external surface,has attracted interest because these host molecules can form aggregates with guest molecules via various noncovalent interactions,including hydrophobic interactions,van der Waals forces,hydrogen bonds,and electrostatic interactions.In this review,we focus mainly on some impressive recent progress,both by our group and other groups,on the construction of cyclodextrin-and calixarene-based organic supramolecular aggregates,control of their topological morphology,and their use for biological applications such as molecular recognition and bioimaging,photodynamic therapy,light-harvesting energy transfer,and targeted drug delivery.We also discuss shortcomings of the current reported results and future prospects for the development of multifunctional organic supramolecular aggregates for use in various fields.

Picard-Type Theorem and Curvature Estimate on an Open Riemann Surface with Ramification

Let M be an open Riemann surface and G:M→Pn(C)be a holomorphic map.Consider the conformal metric on M which is given by ds^(2)=‖■‖^(2m)|w|^(2),where■is a reduced representation of G,ωis a holomorphic 1-form on M and m is a positive integer.Assume that ds^(2) is complete and G is k-nondegenerate(0≤k≤n).If there are q hyperplanes H1,H2,…,Hq■Pn(C)located in general position such that G is ramified over Hj with multiplicity at leastγj(>k)for each j∈{1,2,…,q},and it holds that■,then M is flat,or equivalently,G is a constant map.Moreover,one further give a curvature estimate on M without assuming the completeness of the surface.

Results on Uniqueness Problem for Meromorphic Mappings Sharing Moving Hyperplanes in General Position Under More General and Weak Conditions

The aim of the paper is to deal with the algebraic dependence and uniqueness problem for meromorphic mappings by using the new second main theorem with different weights involved the truncated counting functions,and some interesting uniqueness results are obtained under more general and weak conditions where the moving hyperplanes in general position are partly shared by mappings from Cn into PN(C),which can be seen as the improvements of previous well-known results.

Molecular mechanism analysis of ZmRL6 positively regulating drought stress tolerance in maize

MYB-related genes,a subclass of MYB transcription factor family,have been documented to play important roles in biological processes such as secondary metabolism and stress responses that affect plant growth and development.However,the regulatory roles of MYB-related genes in drought stress response remain unclear in maize.In this study,we discovered that a 1R-MYB gene,ZmRL6,encodes a 96-amino acid protein and is highly drought-inducible.We also found that it is conserved in both barley(Hordeum vulgare L.)and Aegilops tauschii.Furthermore,we observed that overexpression of ZmRL6 can enhance drought tolerance while knock-out of ZmRL6 by CRISPR-Cas9 results in drought hypersensitivity.DAP-seq analyses additionally revealed the ZmRL6 target genes mainly contain ACC GTT,TTA CCA AAC and AGC CCG AG motifs in their promoters.By combining RNA-seq and DAP-seq results together,we subsequently identified eight novel target genes of ZmRL6 that are involved in maize’s hormone signal transduction,sugar metabolism,lignin synthesis,and redox signaling/oxidative stress.Collectively,our data provided insights into the roles of ZmRL6 in maize’s drought response.

Sulfato-β-cyclodextrin induced multivalent supramolecular directional aggregation of cyanovinylene derivatives for achieving reversible near-infrared fluorescence

Molecular aggregation or supramolecular aggregation-induced emission is one of the research hotspots in chemistry,biology,and materials.Herein,we report negatively charged sulfato-β-cyclodextrin(SCD)induced cyanovinylene derivatives(DPy-6C)directional aggregation to form regular nanorods(DPy-6C@SCD)through supramolecular multivalent interactions,not only achieves ultravioletvisible absorption redshifted from 453 to 521 nm but also displays near-infrared(NIR)aggregation-induced emission with a large spectral redshift of 135 nm.The DPy-6C monomer presents random nanosheets with weak fluorescence but obtains regular aggregates after assembly with SCD through electrostatic interactions.In the presence of H^(+),the DPy-6C@SCD can further aggregate into elliptical nanosheets without fluorescence changes due to the protonation of secondary amines.In contrast,the morphology of DPy-6C@SCD becomes flexible and sticks together upon the addition of OH^(−)with an emission blue shift of 72 nm and a 90-fold intensity increase because of disrupting the stacking mode of aggregates,thereby achieving acid-base regulated reversible fluorescence behaviors that cannot be realized by DPy-6C monomer.The DPy-6C@SCD can efficiently select the detection of volatile organic amines both in liquid and gas phases within 5 s at the nanomolar level.Taking advantage of RGB analysis and calculation formula application,the DPy-6C@SCD has been successfully used to monitor various organic amines on a smartphone,accompanied by naked-eye visible photoluminescence.Therefore,the present research provides an efficient directional aggregation method through supramolecular multivalent interactions,which not only realizes topological morphology transformation but also achieves reversible NIR luminescent molecular switch and high sensitivity organic amines fluorescent sensing devices.