A multifunctional, dual-drug carrier platform was successfully constructed. Core-sheU structured NaGdF4：Yb/Er@NaGdF4：Yb@mSiO2-polyethylene glycol （abbreviated as UCNPS） nanopartides loaded with the antiturnor drug...A multifunctional, dual-drug carrier platform was successfully constructed. Core-sheU structured NaGdF4：Yb/Er@NaGdF4：Yb@mSiO2-polyethylene glycol （abbreviated as UCNPS） nanopartides loaded with the antiturnor drug, doxorubicin （DOX） were incorporated into poly（^-caprolactone） （PCL） and gelatin loaded with antiphlogistic drug, indomethacin （MC） to form nanofibrous fabrics （labeled as MC/UCNPS/DOX） via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide （SiO2） and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4：Yb/Er@NaGdF4：Yb embedded in MCfldCNPS/DOX invivo.展开更多
基金This project is financially supported by the National Natural Science Foundation of China （NSFC, Nos. 51332008, 51372243, 51422209, and 51202239）, the National Basic Research Program of China （No. 2014CB643803）.
文摘A multifunctional, dual-drug carrier platform was successfully constructed. Core-sheU structured NaGdF4：Yb/Er@NaGdF4：Yb@mSiO2-polyethylene glycol （abbreviated as UCNPS） nanopartides loaded with the antiturnor drug, doxorubicin （DOX） were incorporated into poly（^-caprolactone） （PCL） and gelatin loaded with antiphlogistic drug, indomethacin （MC） to form nanofibrous fabrics （labeled as MC/UCNPS/DOX） via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide （SiO2） and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4：Yb/Er@NaGdF4：Yb embedded in MCfldCNPS/DOX invivo.
