Previous study showed that the Gle1 RNA export mediator-like (Gle1l) gene and the lymphocyte cytosolic protein 2 (Lcp2) gene were upregulated in response to influenza virus A/Puerto Rico/8/1934 (H1N1) in a mouse mode....Previous study showed that the Gle1 RNA export mediator-like (Gle1l) gene and the lymphocyte cytosolic protein 2 (Lcp2) gene were upregulated in response to influenza virus A/Puerto Rico/8/1934 (H1N1) in a mouse mode. To determine whether these two genes were upregulated in humans after influenza A virus infection, nasopharyngeal swabs were collected from eleven patients with flu-like symptoms for viral RNA extraction and PCR amplification. Sequencing analysis revealed that nucleoprotein (NP) gene fragments amplified from nasopharyngeal swabs of four patients shared the highest similarity with the NP gene from avian influenza A (H5N1) virus (A/ goose/Shantou/753/2002). Peripheral blood samples were then collected from four patients for quantitative analysis of GLE1 and LCP2 gene expression. Our results demonstrated that both GLE1 and LCP2 genes were upregulated in H5N1 influenza A virus infected patients, suggesting that upregulation of GLE1 and LCP2 genes may be important for the host defense against influenza A viruses.展开更多
Heterojunction fabrication is a promising strategy that can greatly boost the charge carrier separation and improve the solar-to-hydrogen conversion efficiency of photoelectrochemical(PEC)cells.However,such technology...Heterojunction fabrication is a promising strategy that can greatly boost the charge carrier separation and improve the solar-to-hydrogen conversion efficiency of photoelectrochemical(PEC)cells.However,such technology still suffers from limited contact interfaces.In this study,the chemical vapor deposition(CVD)technique was for the first time used to construct the CdS/MoS_(2)heterojunction photoanode with a unique core-shell nanoarchitecture,in which a continuous crystalline MoS_(2)nanosheet layer was grown directly on one-dimensional(1D)oriented CdS nanorods(NRs)in a plane-to-plane stacking fashion.The optimization of junction thickness with adjustable MoS_(2)loading from mono to a few layers was achieved by experimental parameters variation.Systematic characterizations show that the MoS_(2)shell plays a dual role as an optical absorption booster for more photo-exciton generation and a surface passivator of trap states.Meanwhile,the formed heterojunction helps regulate the unidirectional charge migration for a significantly suppressed electron-hole recombination process,which synergistically contributes to higher quantum yield and efficiency.As a result,the optimized CdS/MoS_(2)heterojunction photoanode with 3-layered MoS_(2)wrapping exhibits the highest photocurrent density and photoconversion efficiency,over a two-fold increase,compared to those of pristine CdS and the previously reported CdS/MoS_(2)hetero-junctions.Moreover,due to the rapid hole extraction from CdS and transferred surface oxidation sites,the present CdS/MoS_(2)heterostructure demonstrates better corrosion resistance and higher photostability.The present work is expected to provide a versatile platform for exploiting the CVD technique to develop other MoS_(2)-based heterojunction photoelectrodes with extensive PEC applications.展开更多
文摘Previous study showed that the Gle1 RNA export mediator-like (Gle1l) gene and the lymphocyte cytosolic protein 2 (Lcp2) gene were upregulated in response to influenza virus A/Puerto Rico/8/1934 (H1N1) in a mouse mode. To determine whether these two genes were upregulated in humans after influenza A virus infection, nasopharyngeal swabs were collected from eleven patients with flu-like symptoms for viral RNA extraction and PCR amplification. Sequencing analysis revealed that nucleoprotein (NP) gene fragments amplified from nasopharyngeal swabs of four patients shared the highest similarity with the NP gene from avian influenza A (H5N1) virus (A/ goose/Shantou/753/2002). Peripheral blood samples were then collected from four patients for quantitative analysis of GLE1 and LCP2 gene expression. Our results demonstrated that both GLE1 and LCP2 genes were upregulated in H5N1 influenza A virus infected patients, suggesting that upregulation of GLE1 and LCP2 genes may be important for the host defense against influenza A viruses.
文摘Heterojunction fabrication is a promising strategy that can greatly boost the charge carrier separation and improve the solar-to-hydrogen conversion efficiency of photoelectrochemical(PEC)cells.However,such technology still suffers from limited contact interfaces.In this study,the chemical vapor deposition(CVD)technique was for the first time used to construct the CdS/MoS_(2)heterojunction photoanode with a unique core-shell nanoarchitecture,in which a continuous crystalline MoS_(2)nanosheet layer was grown directly on one-dimensional(1D)oriented CdS nanorods(NRs)in a plane-to-plane stacking fashion.The optimization of junction thickness with adjustable MoS_(2)loading from mono to a few layers was achieved by experimental parameters variation.Systematic characterizations show that the MoS_(2)shell plays a dual role as an optical absorption booster for more photo-exciton generation and a surface passivator of trap states.Meanwhile,the formed heterojunction helps regulate the unidirectional charge migration for a significantly suppressed electron-hole recombination process,which synergistically contributes to higher quantum yield and efficiency.As a result,the optimized CdS/MoS_(2)heterojunction photoanode with 3-layered MoS_(2)wrapping exhibits the highest photocurrent density and photoconversion efficiency,over a two-fold increase,compared to those of pristine CdS and the previously reported CdS/MoS_(2)hetero-junctions.Moreover,due to the rapid hole extraction from CdS and transferred surface oxidation sites,the present CdS/MoS_(2)heterostructure demonstrates better corrosion resistance and higher photostability.The present work is expected to provide a versatile platform for exploiting the CVD technique to develop other MoS_(2)-based heterojunction photoelectrodes with extensive PEC applications.
