Multi-blade rubbing characteristics of the shaft-disk-blade-casing system with large rotation

Blade rubbing faults cause detrimental impact on the operation of aeroengines. Most of the existing studies on blade rubbing in the shaft-disk-blade-casing(SDBC) system have overlooked the elastic deformation of the blade, while some only consider the whirl of the rotor, neglecting its spin. To address these limitations, this paper proposes a dynamic model with large rotation for the SDBC system. The model incorporates the spin and whirl of the rotor, enabling the realistic reproduction of multiblade rubbing faults. To verify the accuracy of the SDBC model with large rotation and demonstrate its capability to effectively consider the rotational effects such as the centrifugal stiffening and gyroscopic effects, the natural characteristics and dynamic responses of the proposed model are compared with those obtained from reported research and experimental results. Furthermore, the effects of the rotating speed, contact stiffness,and blade number on the dynamic characteristics of the SDBC system with multi-blade rubbing are investigated. The results indicate that the phase angle between the rotor deflection and the unbalance excitation force increases with the increasing rotating speed,which significantly influences the rubbing penetration of each blade. The natural frequency of the SDBC system with rubbing constrain can be observed in the acceleration response of the casing and the torsional response of the shaft, and the frequency is related to the contact stiffness. Moreover, the vibration amplitude increases significantly with the product of the blade number under rubbing, and the rotating frequency approaches the natural frequency of the SDBC system. The proposed model can provide valuable insight for the fault diagnosis of rubbing in bladed rotating machinery.

IgG N-糖基心血管年龄独立于真实年龄精准表征心血管事件风险

亚临床动脉粥样硬化和代谢紊乱是心血管健康的重要风险因素,应用免疫球蛋白G(IgG)N-聚糖模式作为炎症指标表征其发病风险已有研究报道。然而,对于IgG N-糖基谱在心血管疾病(CVD)风险分层中的能力仍然未知。本研究旨在利用IgG N-糖基标志物开发追踪心血管疾病风险的年龄指数。本研究基于横断面调查,从Busselton健康和老龄研究中共招募1465名40~70岁之间的个体。使用机器学习递归特征消除和惩罚回归算法逐步筛选特征糖基,并开发IgG N-糖基化心血管年龄(GlyCage)指数,以反映归因于心血管风险的与真实年龄间的偏差。结果显示,对GlyCage指数贡献最大的是具有双分叉N-乙酰葡萄糖胺(GlcNAc)的岩藻糖基化N-聚糖(GP6,FA2B)和具有双分叉GlcNAc的双半乳糖基化N-聚糖(GP13,A2BG2)。GlyCage独立于真实年龄,与较高的Framingham十年心血管风险[优势比(OR)为1.09;95%CI:1.05~1.13]和患心血管疾病概率(OR,1.07;95%CI:1.01~1.13)显著相关。GlyCage大于真实年龄三年及以上的个体,其心血管风险和心血管疾病患病概率增加,调整后的OR值分别为2.22(95%CI:1.41~3.53)和2.71(95%CI:1.25~6.41)。GlyCage指数区分十年心血管风险和事件的ROC曲线下面积(AUC)值分别为0.73和0.65,而真实年龄为0.65和0.63。因此,本研究开发的GlyCage指数利用IgG N-糖基谱追踪心血管健康水平。GlyCage和真实年龄之间的差距能够独立地表征心血管风险,提示IgG N-糖基化在心血管疾病的发病机制中起作用。GlyCage指数对心血管风险的预测能力需要在其他人群中进行外部和纵向验证。

ILIDViz:An incremental learning-based visual analysis system for network anomaly detection

Background With the development of information technology,there is a significant increase in the number of network traffic logs mixed with various types of cyberattacks.Traditional intrusion detection systems(IDSs)are limited in detecting new inconstant patterns and identifying malicious traffic traces in real time.Therefore,there is an urgent need to implement more effective intrusion detection technologies to protect computer security.Methods In this study,we designed a hybrid IDS by combining our incremental learning model(KANSOINN)and active learning to learn new log patterns and detect various network anomalies in real time.Conclusions Experimental results on the NSLKDD dataset showed that KAN-SOINN can be continuously improved and effectively detect malicious logs.Meanwhile,comparative experiments proved that using a hybrid query strategy in active learning can improve the model learning efficiency.

Comparisons of different statistical models for analyzing the effects of meteorological factors on COVID-19

Objective:This general non-systematic review aimed to gather information on reported statistical models examing the effects of meteorological factors on coronavirus disease 2019(COVID-19)and compare these models.Methods:PubMed,Web of Science,and Google Scholar were searched for studies on"meteorological factors and COVID-19"published between January 1,2020,and October 1,2022.Results:The most commonly used approaches for analyzing the association between meteorological factors and COVID-19 were the linear regression model(LRM),generalized linear model(GLM),generalized additive model(GAM),and distributed lag non-linear model(DLNM).In addition to these classical models commonly applied in environmental epidemiology,machine learning techniques are increasingly being used to select risk factors for the outcome of interest and establishing robust prediction models.Conclusion:Selecting an appropriate model is essential before conducting research.To ensure the reliability of analysis results,it is important to consider including non-meteorological factors(e.g.,government policies on physical distancing,vaccination,and hygiene practices)along with meteorological factors in the model.

影像引导射频消融治疗肺部肿瘤专家共识(2018年版)

1概述肺癌是最常见的恶性肿瘤之一,在世界各地,肺癌均居恶性肿瘤死亡构成比的第一位,其发病率和死亡率仍在不断升高。据世界卫生组织（World Health Organization,WHO）下属的国际癌症研究机构（International Agency for Research on Cancer,IARC）出版的GLOBOCAN 2012估计：全世界肺癌新发病例1 8 2.5万（男性124.2万,女性58.3万）.

Review on Dynamic Modeling and Vibration Characteristics of Rotating Cracked Blades

As one of the most important parts in the engine,the structure and state of the rotating blade directly affect the normal performance of the aeroengine.In order to monitor engine crack failure and ensure flight safety,it is necessary to carry out research on the dynamic modeling of the cracked blade and breathing crack-induced vibration mechanisms.This paper summarizes the current research status on the dynamics of cracked blade,and the related topics mainly include four aspects:crack propagation path,mechanical model of open and breathing cracks,dynamic modeling methods of cracked blades such as lumped mass model,semi-analytical model and finite element model,and dynamic characteristics of cracked blades.The review will provide valuable references for future studies on dynamics and fault diagnosis of cracked blade in aeroengine.

Transformation of human amniotic epithelial cells into neuron-like cells in the microenvironment of traumatic brain injury in vivo and in vitro

Survival and differentiation of transplanted cells is closely related to the local microenvironment.The present study cultured human amniotic epithelial cells(HAECs) in a simulated microenvironment in vitro comprising RPMI 1640 culture medium and the solution extracted from injured brain tissues.Some HAECs were round,triangular in form or irregularly shaped,with extended neuron-like processes;some of the processes were interconnected,representing neuron-like morphology and some HAECs were microtubule-associated protein 2-positive.HAECs survived for at least 4 weeks following transplantation into the center and edges of the trauma focus with traumatic brain injury,and were microtubule-associated protein 2-positive.Moreover,the motor function of rat hind limbs was significantly improved.

Sensitivity of WRF simulated typhoon track and intensity over the South China Sea to horizontal and vertical resolutions

To determine the grid resolutions of the WRF model in the typhoon simulation,some sensitivity analysis of horizontal and vertical resolutions in different conditions has been carried out.Different horizontal resolutions(5,10,20,30 km),nesting grids(15 and 5 km),different vertical resolutions(35-layers,28-layers,20-layers)and different top maximum pressures(1 000,2 000,3 500,5 000 Pa)had been used in the mesoscale numerical model WRF to simulate the Typhoon Kai-tak.The simulation results of typhoon track,wind speed and sea level pressure at different horizontal and vertical resolutions have been compared and analyzed.The horizontal and vertical resolutions of the model have limited effect on the simulation effect of the typhoon track.Different horizontal and vertical resolutions have obvious effects on typhoon strength(defined by wind speed)and intensity(defined by sea level pressure,SLP),especially for sea level pressure.The typhoon intensity simulated by the high-resolution model is closer to the real situation and the nesting grids can improve computational accuracy and efficiency.The simulation results affected by vertical resolution using 35-layers is better than the simulation results using 20-layers and 28-layers simulations.Through comparison and analysis,the horizontal and vertical resolutions of WRF model are finally determined as follows:the two-way nesting grid of 15 and 5 km is comprehensively determined,and the vertical layers is 35-layers,the top maximum pressure is 2 000 Pa.

Human amniotic epithelial cells express specific markers of nerve cells and migrate along the nerve fibers in the corpus callosum

Human amniotic epithelial cells were isolated from a piece of fresh amnion. Using immunocytochemical methods, we investigated the expression of neuronal phenotypes (microtubule-associated protein-2, glial fibrillary acidic protein and nestin) in human amniotic epithelial cells. The conditioned medium of human amniotic epithelial cells promoted the growth and proliferation of rat glial cells cultured in vitro, and this effect was dose-dependent. Human amniotic epithelial cells were further transplanted into the corpus striatum of healthy adult rats and the grafted cells could integrate with the host and migrate 1-2 mm along the nerve fibers in corpus callosum. Our experimental findings indicate that human amniotic epithelial cells may be a new kind of seed cells for use in neurograft.

A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers

Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance.

Arterial stimulation with simultaneous venous sampling for localizing insulinomas

Purpose: The present study aimed to assess the accuracies of arterial stimulation with simultaneous venous sampling(ASVS) in preoperative localization of insulinomas. Materials and Methods: A cohort consisting of 6 males and 14 females(median age, 48.5y; range, 28–62y) with pathologically proven insulinomas were included in this study. Selective angiographies were performed with the superior mesenteric artery(SMA), gastroduodenal artery(GDA), proximal splenic artery, and midsplenic artery in all individuals. Then ASVS procedures were followed after angiographies for these arteries. Clinical characteristics of the patient and the tumor number, location, and size were recorded. The accuracy of preoperative localization of insulinomas was tested. Results: A total of 22 tumors were identified by histopathological diagnosis. The mean size of the tumor was 1.40±0.60 cm. Five tumors were in the head/neck region and 17 in the body/tail region. ASVS accurately localized 17/20(85%) cases with only biochemical data and 19/20(95%) cases with biochemical data and angiography images. Variant pancreatic arterial anatomy was revealed in 2 false cases with inferior pancreatic artery replaced by the superior mesenteric artery. Conclusion: ASVS was highly accurate in localizing insulinomas and should be performed in most of the patients with suspected insulinomas before the operation.

Application of Integrated Reorganization of Science Specimen Data Using Kettle

Standards and specifications are the premise of integrated reorganization of science specimen data, and data integration is the core of the reorganization. ETL [1] which is the abbreviation of extract, transform, and load [2], is very suitable for data integration. Kettle is a kind of ETL software. In this paper, it has been introduced into the integrated reorganization of science specimen data. Multi-source and heterogeneous specimen data are integrated using kettle, and good results have been achieved. It proved the effectiveness of kettle in the integrated reorganization of science specimen data. The application has practical significance, and the method can be referenced when reorganizing other resource data.

Irreversible electroporation treatment of pheochromocytoma at a complex site: A case report

A 24-year-old man was seen 2 years prior for hematuria,hypertension(165/120 mmHg),and palpitations.The plasma normetanephrine(NMN)level was elevated(9812.4 pg/mL).Computed tomography(CT)showed bilateral adrenal tumors(Fig.1).Of the two tumors on the left adrenal gland,the lesion on the head aspect was relatively large,while that on the feet aspect(arrow)was relatively small and adjacent to the left renal artery.There was one lesion on the right adrenal gland.Positron emission tomography(PET)-CT showed increased radioactive tracer uptake in the regions of the bilateral adrenal tumors(Fig.2).The clinical diagnosis was pheochromocytoma.

TRAF7 enhances degradation of ubiquitinated KLF4 to promote hepatocellular carcinoma progression

Objective:The tumor necrosis factor receptor-associated factor 7(TRAF7)is one of the components of the tumor necrosis factor alpha(TNF-α)/nuclear factor kappa B(NF-κB)pathway and a putative E3-ubiquitin ligase.This study aims to explore the biologic effects and the molecular mechanisms of deregulated TRAF7 signaling in hepatocellular carcinoma(HCC)progression.

XCL1/Glypican-3 fusion protein induces potent CD8^+ T-cell generation and enhances the anti-PD1 effect to suspend hepatocellular carcinoma development

Objective:To induce potent CD8^+T-cells against glypican-3(GPC3),which is overexpressed in hepatocellular carcinoma(HCC),to suspend tumor development.Methods:Since the chemokine receptor XCR1 is selectively expressed on professional cross-presenting CD8α^+dendritic cells(DCs).

补片式颈动脉内膜剥脱术与外翻式颈动脉内膜剥脱术长期随访结果比较

目的比较补片式颈动脉内膜剥脱术(p-CEA)与外翻式颈动脉内膜剥脱术(e-CEA)的长期疗效。方法回顾性分析2009年10月至2015年10月在北京协和医院血管外科接受颈动脉内膜剥脱术(CEA)治疗的颈动脉狭窄患者的临床资料(共计340例患者372例次手术,其中p-CEA为193例次,e-CEA为179例次),比较两种手术方式远期的全因死亡、心肌梗死、所有卒中及手术同侧卒中发生率,以及症状复发率。结果2组基线结果比较显示,p-CEA组患者高脂血症比例高于e-CEA组,差异有统计学意义(46.1%vs 34.6%,P=0.032)。在133个月的随访期间,p-CEA组的病死率、心肌梗死发生率均高于e-CEA组,卒中发生率、手术同侧卒中发生率均低于e-CEA组,但差异均无统计学意义(17.8%vs 13.8%,P=0.4855;7.8%vs 5.9%,P=0.360;12.8%vs 15.6%,P=0.228;4.3%vs 5.9%,P=0.282);2组在术后症状复发上,差异亦无统计学意义(χ2=0.198,df=15.622,P=0.85)。Kaplan-Meier分析显示,在第6年,2组之间术后再狭窄和术后死亡比较,差异无统计学意义(P=0.87;P=0.18);在第8年,2组之间术后死亡和卒中比较,差异无统计学意义(P=0.34;P=0.24)。结论p-CEA组和e-CEA组的远期死亡、心肌梗死、所有卒中和手术同侧卒中,以及术后症状复发等均无差异,均可作为治疗颈动脉狭窄的有效方法。

Estimation of the population,death,and quality of life in Shaanxi Province,western China:a cross-sectional study

Background:Measuring the health of the population is of great significance to the development of a region.We aimed to estimate the population,probability of death,and quality of life in western China.Methods:We calculated the age-specific mortality rate and prevalence rate of diseases and injuries using the Full Population Database and the Home Page of Inpatient Medical Record.We used multiple interpolation methods to insert missing information from the death data and the model of Kannisto to adjust the mortality rate for elderly individuals.The age-specific prevalence rate of diseases and injuries was adjusted according to the standard ratio of age and methods of equal proportional allocation.Life expectancy was calculated by a life table,and the quality of life was estimated using the Sullivan method.Results:The total population continued to increase in 2015 to 2019 in the Shaanxi Province,China.The mortality rate of children under five has improved,and the mortality rate of people over 65 is decreasing year by year.Life expectancy increased from 74.66 years in 2015 to 77.19 years in 2019.Even with the total risk of disease and injury,the health-adjusted life expectancy increased by 1.90 years within 5 years,and the number of unhealthy years significantly improved.Health-adjusted life expectancy increased by 1.75 years when only considered the ten major disease systems(tumors;endocrinology,nutrition and metabolism;mental and behavioral disorders;nervous system;sensory diseases;circulatory system;respiratory system;digestive system;genitourinary system;musculoskeletal system and connective tissue),and the number of unhealthy years increased slightly.Conclusions:In the past five years,Shaanxi Province has made progress in improving life expectancy and controlling the development of chronic diseases.It is necessary to take specific preventive measures and improve the quality of basic public health services.

Visualization of Macrophase Separation and Transformation in Immiscible Polymer Blends

Identification and visualization of phase structures inside polymer blends are of critical importance in the understanding of their intrinsic structure and dynamics.However,the direct optical observation of the individual component phase in a dense bulk material poses a significant challenge.Herein,three-dimensional fluorescence imaging of phase separation and realtime visualization of phase transformation in immiscible polymer blends of polypropylene and polystyrene is realized through multiphoton laser scanning microscopy.Owing to the specific fluorescence behavior of the cyanostyrene derivative 2-(4-bromophenyl)-3-(4-(4-(diphenylamino)styryl)phenyl)fumaronitrile,the high-contrast imaging of the macrophase of the component polymer in two and three dimensions with a maximum depth of 140μm and a high signal-to-noise ratio of 300 can be achieved.Detailed spectroscopic and structural studies reveal that the distinctive fluorescence features of each phase domain should originate from the formation of a completely different aggregate between probes and component polymer.Furthermore,visualizations of the internal morphology deformation and macrophase transformation were realized by employing a stretched dumbbell sample under constant tension.

基于海气耦合模式的南中国海北部风暴潮模拟

伴随台风产生的大风、暴雨、巨浪、风暴潮形成的台风灾害链对沿岸地区产生巨大影响,研究台风的形成和运动机理,减小风暴潮灾害,具有重要的科学价值和社会意义.台风影响期间,大气与海洋之间存在强烈的质量、能量交换,风场、流场、波浪场等物理场相互作用、相互影响.基于中尺度大气模式WRF和区域海洋模式ROMS,构建南中国海地区海气耦合模式,针对2012年台风"启德"进行数值模拟.通过观测数据对台风路径和强度进行验证,结果表明,建立的WRF-ROMS耦合模式在对台风"启德"影响下的南中国海风暴潮模拟中展现出较高的模拟精度.通过数值模式计算结果揭示了台风、风暴增水和风生流场的时空分布特征.台风运动过程中台风动力场、风暴增水及流场在空间上均具有"右偏性"的不对称分布特征,近岸风暴增水对台风的响应在时间上存在滞后性,风生流场具有较明显的滞后性特征.

基于近场动力学的梁结构振动特性分析方法研究

基于欧拉梁理论推导了两自由度梁的常规态型近场动力学(Peridynamics,PD)模型,并提出一种新的自由边界条件施加方法,对不同边界条件的PD梁进行了模态分析,与局部梁的有限元结果进行了对比,验证了模型的收敛性,分析了PD非局部参数对固有频率的影响.结果表明,当近场作用域内物质点密度较小时,PD梁模型非局部性较弱,与局部梁的有限元结果接近,随着物质点密度逐渐增大,非局部作用增强,PD梁的固有频率逐渐降低;当尺度参数趋于零时,PD梁的固有频率收敛到局部梁的有限元解,PD梁退化为局部梁.研究表明,论文提出的PD梁模型和自由边界施加方法适用于分析梁的振动特性,为采用PD方法分析梁结构的动力特性提供了参考.