Multimodal Sentiment Analysis Using BiGRU and Attention-Based Hybrid Fusion Strategy

Recently,multimodal sentiment analysis has increasingly attracted attention with the popularity of complementary data streams,which has great potential to surpass unimodal sentiment analysis.One challenge of multimodal sentiment analysis is how to design an efficient multimodal feature fusion strategy.Unfortunately,existing work always considers feature-level fusion or decision-level fusion,and few research works focus on hybrid fusion strategies that contain feature-level fusion and decision-level fusion.To improve the performance of multimodal sentiment analysis,we present a novel multimodal sentiment analysis model using BiGRU and attention-based hybrid fusion strategy(BAHFS).Firstly,we apply BiGRU to learn the unimodal features of text,audio and video.Then we fuse the unimodal features into bimodal features using the bimodal attention fusion module.Next,BAHFS feeds the unimodal features and bimodal features into the trimodal attention fusion module and the trimodal concatenation fusion module simultaneously to get two sets of trimodal features.Finally,BAHFS makes a classification with the two sets of trimodal features respectively and gets the final analysis results with decision-level fusion.Based on the CMU-MOSI and CMU-MOSEI datasets,extensive experiments have been carried out to verify BAHFS’s superiority.

Comparison of clinical outcomes of Chinese men and women after coronary stenting for coronary artery disease:a multi-center retrospective analysis of 4,334 patients

The outcome differences between Chinese male and female patients within one-year follow-up after percutaneous coronary intervention（PCI） with stent remain unclear.The present study was aimed to compare clinical outcomes in such two populations.From May 1999 to December 2009,4,334 patients with acute myocardial infarction（MI）,unstable angina,stable angina,or silent ischemia,who underwent PCI,were registered at our centers.Among these,3,089 were men and 1,245 were women.We compared these groups with respect to the primary outcomes of MI and secondary outcomes including a composite of major adverse cardiac events（MACE） including cardiac death,MI,target lesion revascularization,target vessel revascularization（TVR）,stent thrombosis（ST）,definite ST and probable ST at one-year follow-up.Chinese male patients had a higher MACE rate（13%vs.10.7%,P =0.039）,mainly led by TVR（9.09%vs.6.98%,P=0.024） at one year,which was significantly different than female patients.Chinese male and female patients showed a significant difference on MACEs.However,there was no significant difference with respect to MI between these groups.

Expression of IL-6 and TNF-α in benign prostatic hyperplasia combined with histological inflammation

Objective:To detect the expression of TNF-αand IL-6 in simple benign prostatic hyperplasia(BPH)and BPH combined with prostatitis,and to evaluate the effect of inflammation of the development and progression of BPH.Methods:Specimens of 90 patients with BPH underwent transurethral resection of prostate(TURP)were obtained.All speci-mens were divided histologically by HE staining into group of 35 cases of simple BPH(A group)and group of 55 cases of BPH combined with prostatitis(B group).Proteins levels of TNF-αand IL-6 were examined by immunohistochemistry.All patients’clinical indicators including PSA,prostate volume,age,urinary flow rate were recorded,and all patients were diagnosed as BPH by pathology.Results:All patients of B group were found combined with chronic prostatitis.The constituent ratio was 61%.Patients’prostate volume and PSA of B group were significant higher than A group(p<.05),but there were no significant differences in urine flow rate and patients’age(p>.05).As compared with A group,the expression of TNF-αand IL-6 significantly increased in B group(p<.05).The results of analysis were as follows:there existed a moderate correlation between prostate volume and patients’age(r=0.430,p<.001);there existed a moderate correlation between prostate volume and the degree of inflammation(r=0.610 and r=0.609,p<.01);there existed a moderate correlation between PSA and the degree of inflammation(r=0.572 and r=0.487,p<.01);there was not significant correlation between PSA and patients’age(r=0.065,p>.1);controlling influence of the age factor by partial correlation analysis,there was still a significant correlation between the prostate volume and level of inflammation.Conclusions:Most BPH patients are combined with prostatitis especially chronic inflammation.TNF-αand IL-6 are two-pro-inflammation cytokines,which obtain high expression in the prostate tissue combined with histological inflammation.Patients’prostate volume and PSA of BPH combined with prostatitis are significantly higher than those of simple BPH.However,there are no significant differences in urine flow rate and patients’age.These two cytokines may play an important part in promoting BPH and secretion of PSA.

Analysis and treatment of delayed hemorrhage after partial nephrectomy

Objective: To explore the causes of delayed hemorrhage after partial nephrectomy and its prevention and treatment methods. Methods: Clinical data for 64 cases of patients who received partial nephrectomy from August of 2010 to December of 2015 were retrospectively analyzed;whereas, 3 cases of patients (4.7%) had delayed hemorrhage, including 1 case of male patient and 2 cases of female patients. Then, compared them with patients with no hemorrhage to explore the risk factors for hemorrhage after partial nephrectomy. Results: Three cases of patients showed a large volume of gross hematuria in 7-22 days (the average was 16.3 days) after partial nephrectomy, with blood pressure and hemoglobin (HGB) decreased. 2 cases of patients with hemorrhage were given blood transfusion and conservative treatment, and patients' conditions were improved obviously. The other patient was given super-selective renal artery embolization (SRAE), with renal arteriography indicating the presence of pseudoaneurysm. Hematuria disappeared after surgery. In comparison with the non-hemorrhage group, warm ischemia time was longer in the hemorrhage group, and the difference was of statistical significance (p < .05). Conclusions: Hemorrhage occurred after partial nephrectomy is mostly delayed. Once the type of complications happens, it is required to provide a timely treatment. Super-selective renal artery embolization (SRAE) is a safe and effective treatment method for hemorrhage after partial nephrectomy.

Clinical study of different immune induction and BK virus infection after renal transplantation

Objective:To monitor the incidence of BK virus infection in hematuria of renal transplant recipients induced by different immunizations.Methods:A total of 109 patients who underwent renal transplantation in Baogang Hospital of Inner Mongolia from January 2019 to December 2022 were analyzed retrospectively.The results of BK virus DNA detection in urine and blood were observed after operation.They were divided into three groups according to different immunosuppressive induction regimens;35 patients in group A,42 patients in group B,and 32 patients in group C(basiliximab).To explore the effect of different immune induction regimens on BK virus infection in renal transplant recipients.Results:The positive rate of urine BK virus in all patients in 1 month after operation was 10.09%(11/109),which was significantly higher than that of blood BK virus 0%(0/109),and the difference had a statistical significance(p<.05).The positive rate of urine BK virus in all patients in 6 months after operation was 31.19%(34/109),which was significantly higher than that of blood BK virus 3.67%(4/109),and the difference had a statistical significance(p<.05).The positive rate of urine BK virus in all patients in 12 months after operation was 35.79%(39/109),which was significantly higher than that of blood BK virus 5.50%(6/109),and the difference had a statistical significance(p<.05).The urinary BK virus infection rate was increased significantly from 1 month to 6 months after operation,but was not increased significantly from 6 months to 12 months after operation.There was a statistically significant difference between the two groups(p<.05).The BK virus infection rate in renal transplant recipients induced by basiliximab within the first month was significantly lower than that in patients using polyclonal antibodies,but the urinary BK virus infection rate after one year was not significantly different from that in patients using polyclonal antibodies.Conclusions:There are slight differences in BK virus infection after early renal transplantation with different immune induction therapies,but there is no significant difference in the long-term.It is recommended to strengthen the early monitoring of BK virus after renal transplantation,timely adjust immunosuppressive regimens to achieve the early detection and early treatment.

Diagnosis and treatment of Wilms tumor

We collected a medical record of“Wilms’tumor”in the Department of Urology at the Third Affiliated Hospital of Inner Mongolia Medical University,and discussed the diagnosis,auxiliary examination and treatment of the disease.We hope to expand clinical thinking,improve our diagnosis and treatment of the disease through data analysis.

Ureteral endometriosis: A case report

A case of endometriosis of ureter in the Department of Gynaecology and Obstetrics of the Third Affiliated Hospital of Inner Mongolia Medical School was collected and analyzed on the basis of diagnosis, physical examination and treatment. The disease was rare due to its atypical clinical symptoms so that it was difficult to diagnose. The paper aims to expand our thinking and improve the gynecologists awareness and the level of diagnosis and treatment of rare diseases through the clinical analysis of the case.

Efficacy and safety of LY01005 versus goserelin implant in Chinese patients with prostate cancer: A multicenter, randomized, open-label, phase III, non-inferiority trial

Background:LY01005(Goserelin acetate sustained-release microsphere injection)is a modified gonadotropin-releasing hormone(GnRH)agonist injected monthly.This phase III trial study aimed to evaluated the efficacy and safety of LY01005 in Chinese patients with prostate cancer.Methods:We conducted a randomized controlled,open-label,non-inferiority trial across 49 sites in China.This study included 290 patients with prostate cancer who received either LY01005 or goserelin implants every 28 days for three injections.The primary efficacy endpoints were the percentage of patients with testosterone suppression≤50 ng/dL at day 29 and the cumulative probability of testosterone≤50 ng/dL from day 29 to 85.Non-inferiority was prespecified at a margin of-10%.Secondary endpoints included significant castration(≤20 ng/dL),testosterone surge within 72 h following repeated dosing,and changes in luteinizing hormone,follicle-stimulating hormone,and prostate specific antigen levels.Results:On day 29,in the LY01005 and goserelin implant groups,testosterone concentrations fell below medical-castration levels in 99.3%(142/143)and 100%(140/140)of patients,respectively,with a difference of-0.7%(95%confidence interval[CI],-3.9%to 2.0%)between the two groups.The cumulative probabilities of maintaining castration from days 29 to 85 were 99.3%and 97.8%,respectively,with a between-group difference of 1.5%(95%CI,-1.3%to 4.4%).Both results met the criterion for non-inferiority.Secondary endpoints were similar between groups.Both treatments were well-tolerated.LY01005 was associated with fewer injection-site reactions than the goserelin implant(0%vs.1.4%[2/145]).Conclusion:LY01005 is as effective as goserelin implants in reducing testosterone to castration levels,with a similar safety profile.Trial registration:ClinicalTrials.gov,NCT04563936.