The quantization algorithm compresses the original network by reducing the numerical bit width of the model,which improves the computation speed. Because different layers have different redundancy and sensitivity to d...The quantization algorithm compresses the original network by reducing the numerical bit width of the model,which improves the computation speed. Because different layers have different redundancy and sensitivity to databit width. Reducing the data bit width will result in a loss of accuracy. Therefore, it is difficult to determinethe optimal bit width for different parts of the network with guaranteed accuracy. Mixed precision quantizationcan effectively reduce the amount of computation while keeping the model accuracy basically unchanged. In thispaper, a hardware-aware mixed precision quantization strategy optimal assignment algorithm adapted to low bitwidth is proposed, and reinforcement learning is used to automatically predict the mixed precision that meets theconstraints of hardware resources. In the state-space design, the standard deviation of weights is used to measurethe distribution difference of data, the execution speed feedback of simulated neural network accelerator inferenceis used as the environment to limit the action space of the agent, and the accuracy of the quantization model afterretraining is used as the reward function to guide the agent to carry out deep reinforcement learning training. Theexperimental results show that the proposed method obtains a suitable model layer-by-layer quantization strategyunder the condition that the computational resources are satisfied, and themodel accuracy is effectively improved.The proposed method has strong intelligence and certain universality and has strong application potential in thefield of mixed precision quantization and embedded neural network model deployment.展开更多
The demand for adopting neural networks in resource-constrained embedded devices is continuously increasing.Quantization is one of the most promising solutions to reduce computational cost and memory storage on embedd...The demand for adopting neural networks in resource-constrained embedded devices is continuously increasing.Quantization is one of the most promising solutions to reduce computational cost and memory storage on embedded devices.In order to reduce the complexity and overhead of deploying neural networks on Integeronly hardware,most current quantization methods use a symmetric quantization mapping strategy to quantize a floating-point neural network into an integer network.However,although symmetric quantization has the advantage of easier implementation,it is sub-optimal for cases where the range could be skewed and not symmetric.This often comes at the cost of lower accuracy.This paper proposed an activation redistribution-based hybrid asymmetric quantizationmethod for neural networks.The proposedmethod takes data distribution into consideration and can resolve the contradiction between the quantization accuracy and the ease of implementation,balance the trade-off between clipping range and quantization resolution,and thus improve the accuracy of the quantized neural network.The experimental results indicate that the accuracy of the proposed method is 2.02%and 5.52%higher than the traditional symmetric quantization method for classification and detection tasks,respectively.The proposed method paves the way for computationally intensive neural network models to be deployed on devices with limited computing resources.Codes will be available on https://github.com/ycjcy/Hybrid-Asymmetric-Quantization.展开更多
AIM: To observe the therapeutic effects of liposomeencapsulated adriamycin (LADM) on hepatoma in comparison with adriamycin solution (FADM) and adriarnycin plus blank liposome (ADM + BL) administered into the ...AIM: To observe the therapeutic effects of liposomeencapsulated adriamycin (LADM) on hepatoma in comparison with adriamycin solution (FADM) and adriarnycin plus blank liposome (ADM + BL) administered into the hepatic artery of rats. METHODS: LADM was prepared by pH gradient-driven method. Normal saline, FADM (2 mg/kg), ADM+BL (2 mg/kg), and LADM (2 mg/kg) were injected via the hepatic artery in rats bearing liver W256 carcinosarcoma, which were divided into four groups randomly. The therapeutic effects were evaluated in terms of survival time, tumor enlargement ratio, and tumor necrosis degree. The difference was determined with ANOVA and Dunnett test and log rank test. RESULTS: Compared to FADM or ADM + BL, LADM produced a more significant tumor inhibition (tumor volume ratio: 1.243±0.523 vs 1.883±0.708, 1.847±0.661, P 〈 0.01), and more extensive tumor necrosis. The increased life span was prolonged significantly in rats receiving LADM compared with FADM or ADM+BL (231.48 vs 74.66, 94.70) (P 〈 0.05). CONCLUSION: The anticancer efficacies of adriamycin on hepatoma can be strongly improved by liposomal encapsulation through hepatic arterial administration.展开更多
As an industrial solid waste,pyrite cinder exhibited excellent reactivity and cycle stability in chemical looping combustion.Prior to the experiment,oxygen carriers often experienced a high temperature calcination pro...As an industrial solid waste,pyrite cinder exhibited excellent reactivity and cycle stability in chemical looping combustion.Prior to the experiment,oxygen carriers often experienced a high temperature calcination process to stabilize the physico-chemical properties,which presented significant influence on the redox performance of oxygen carriers.However,the effect of calcination temperature on the cyclic reaction performance of pyrite cinder has not been studied in detail.In this work,the effect of calcination temperature on the redox activity and attrition characteristic of pyrite cinder were studied in a fluidizedbed reactor using CH_(4) as fuel.A series of pyrite cinder samples were prepared by controlling the calcination temperature.The redox activity and attrition rate of the obtained pyrite cinder samples were investigated deeply.The results showed that calcination temperature displayed significant impact on the redox performance of pyrite cinder.Considering CH_(4) conversion(80%–85%)and attrition resistance,the pyrite cinder calcined at 1050℃ presented excellent redox properties.In the whole experiment process,the CO_(2) selectivity of the pyrite cinder samples were not affected by the calcination temperature and were still close to 100%.The results can provide reference for optimizing the calcination temperature of pyrite cinder during chemical looping process.展开更多
Chemical looping combustion(CLC)is a clean and efficient flame-free combustion technology,which combust the fuels by lattice oxygen from a solid oxygen carrier with inherent CO_(2)capture.The development of oxygen car...Chemical looping combustion(CLC)is a clean and efficient flame-free combustion technology,which combust the fuels by lattice oxygen from a solid oxygen carrier with inherent CO_(2)capture.The development of oxygen carriers with low cost and high redox performance is crucial to the whole efficiency of CLC process.As the solid by-product from the sulfuric acid production,pyrite cinder presented excellent redox performance as an oxygen carrier in CLC process.The main components in pyrite cinder are Fe_(2)O_(3),CaSO_(4),Al_(2)O_(3)and SiO_(2)in which Fe_(2)O_(3)is the active component to provide lattice oxygen.In order to systematic investigate the functions of supports(CaSO_4,Al_(2)O_(3)and SiO_(2))in pyrite cinder,three oxygen carriers(Fe_(2)O_(3)-CaSO_(4),Fe_(2)O_(3)-Al_(2)O_(3)and Fe_(2)O_(3)-SiO_(2))were prepared and evaluated in this study.The results showed that Fe_(2)O_(3)-CaSO_(4) displayed high redox activity and cycling stability in the multiple redox cycles.However,both Fe_(2)O_(3)-Al_(2)O_(3)and Fe_(2)O_(3)-SiO_(2)experienced serious deactivation during redox reactions.It indicated that the inert Fe-Si solid solution(Fe_(2)SiO_(4))was formed in the spent Fe_(2)O_(3)-SiO_(2)sample,which decreased the oxygen carrying capacity of this sample.The XPS results showed that the oxygen species on the surface of Fe_(2)O_(3)-CaSO_(4) could be fully recovered after the 20 redox cycles.It can be concluded that CaSO_(4) is the key to the high redox activity and cycling stability of pyrite cinder.展开更多
Current electronics are driven by advanced microfabrication for fast and efficient information processing.In spite of high performance,these wafer-based devices are rigid,non-degradable,and unable to autonomous repair...Current electronics are driven by advanced microfabrication for fast and efficient information processing.In spite of high performance,these wafer-based devices are rigid,non-degradable,and unable to autonomous repair.Skin-inspired electronics have emerged as a new class of devices and systems for next-generation flexible and wearable electronics.The technology gains inspiration from the structures,properties,and sensing mechanisms of the skin,which may find a broad range of applications in cutting-edge fields such as healthcare monitoring,human-machine interface,and soft robotics/prostheses.Practical demands have fueled the development of electronic materials with skin-like properties in terms of stretchability,self-healing capability,and biodegradability.These materials provide the basis for functional sensors with innovative and biomimetic designs.Further system-level integrations and optimizations enable new forms of electronics for real-world applications.This review summarizes recent advancements in this active area and speculates on future directions.展开更多
Electronic skin(e-skin),a kind of flexible sensor arrays and system that mimic the properties and sensing functions of human skin,represents a new paradigm of sensing and control(Fig.1).The noun of'skin electronic...Electronic skin(e-skin),a kind of flexible sensor arrays and system that mimic the properties and sensing functions of human skin,represents a new paradigm of sensing and control(Fig.1).The noun of'skin electronics'made its debut in the Sensitive Skin Workshop organized jointly by the National Science Foundation and Defense Advanced Research Projects Agency of USA in October 1999 in Arlington.展开更多
The emission of nitrogen oxides(NO_(x))increases year by year,causing serious problems to our livelihoods.The photocatalytic oxidation of NO_(x)has attracted more attention recently because of its effi cient removal o...The emission of nitrogen oxides(NO_(x))increases year by year,causing serious problems to our livelihoods.The photocatalytic oxidation of NO_(x)has attracted more attention recently because of its effi cient removal of NO_(x),especially for low concentra-tions of NO_(x).In this review,the mechanism of the photocatalytic oxidation of NO_(x)is described.Then,the recent progress on the development of photocatalysts is reviewed according to the categories of inorganic semiconductors,bismuth-based compounds,nitrogen carbide polymer,and metal organic frameworks(MOFs).In addition,the photoelectrocatalytic oxida-tion of NO_(x),a method involving the application of an external voltage on the photocatalytic system to further increase the removal effi ciency of NO_(x),and its progress are summarized.Finally,we outline the remaining challenges and provide our perspectives on the future directions for the photocatalytic oxidation of NO_(x).展开更多
Metal-free heteroatoms dual-doped carbon has been recognized as one of the most promising Pt/C-substitutes for oxygen reduction reaction(ORR).Herein,we optimize the preparation process by doping order of metal-free he...Metal-free heteroatoms dual-doped carbon has been recognized as one of the most promising Pt/C-substitutes for oxygen reduction reaction(ORR).Herein,we optimize the preparation process by doping order of metal-free heteroatoms to obtain the best electrocatalytic performance through three types of dual-doped carbon,including XC-N(first X doping then N doping),NC-X(first N doping then X doping) and NXC(N and X doping)(X=P,S and F).XC-N has more defect than the other two indicated by Raman spectra.X-ray photoelectron spectrom(XPS) measurements indicate that N and X have been dual-doped into the carbon matrix with different doping contents and modes,Electrocatalytic results,including the potential of ORR peak(Ep),the half-wave potential,the diffusion-limiting current density mainly follows the order of XC-N>NC-X> NXC,Furthermore,the synergistic effect of second atom doping are also compared with the single doped carbon(NC,PC,SC and FC).The differences in electronegativity and atomic radius of these metal-free heteroatoms can affect the defect degree,the doping content and mode of hete roatoms on carbon matrix,induce polarization effect and space effect to affect O2 adsorption and product desorption,ultimately to the ORR electrocatalytic performance.展开更多
Phosphorus (P) is a major limiting factor for plant productivity in many ecosystems and agriculture. The projected increase in atmospheric CO2 is likely to result in changes in plant mineral consumption and growth. ...Phosphorus (P) is a major limiting factor for plant productivity in many ecosystems and agriculture. The projected increase in atmospheric CO2 is likely to result in changes in plant mineral consumption and growth. We studied P depletion by common bean (Phaseolus vulgaris) cultured hydroponically under ambient (377±77μmol mol^-1) or elevated (650±32 μmol mol^-1) CO2 in media of low or high P. Under elevated CO2 compared to ambient CO2, the maximum P depletion rate increased by 98% at low P and 250% at high P, and P was depleted about 2-5 weeks sooner; leaf acid phosphatase (APase) activity and chlorophyll content both increased significantly; root-to-shoot ratio increased significantly at high P, although it was unaffected at low P; lateral root respiration rate showed no change, suggesting that COs did not affect P depletion via metabolic changes to the roots; the total biomass at final harvest was significantly higher at both low and high P. Our data showed that the increased rate and amount of P depletion during plant growth under elevated CO2 occurred in association with alterations in leaf biochemical properties, i.e., enhanced activities of leaf APase and increased leaf chlorophyll content.展开更多
文摘The quantization algorithm compresses the original network by reducing the numerical bit width of the model,which improves the computation speed. Because different layers have different redundancy and sensitivity to databit width. Reducing the data bit width will result in a loss of accuracy. Therefore, it is difficult to determinethe optimal bit width for different parts of the network with guaranteed accuracy. Mixed precision quantizationcan effectively reduce the amount of computation while keeping the model accuracy basically unchanged. In thispaper, a hardware-aware mixed precision quantization strategy optimal assignment algorithm adapted to low bitwidth is proposed, and reinforcement learning is used to automatically predict the mixed precision that meets theconstraints of hardware resources. In the state-space design, the standard deviation of weights is used to measurethe distribution difference of data, the execution speed feedback of simulated neural network accelerator inferenceis used as the environment to limit the action space of the agent, and the accuracy of the quantization model afterretraining is used as the reward function to guide the agent to carry out deep reinforcement learning training. Theexperimental results show that the proposed method obtains a suitable model layer-by-layer quantization strategyunder the condition that the computational resources are satisfied, and themodel accuracy is effectively improved.The proposed method has strong intelligence and certain universality and has strong application potential in thefield of mixed precision quantization and embedded neural network model deployment.
基金The Qian Xuesen Youth Innovation Foundation from China Aerospace Science and Technology Corporation(Grant Number 2022JY51).
文摘The demand for adopting neural networks in resource-constrained embedded devices is continuously increasing.Quantization is one of the most promising solutions to reduce computational cost and memory storage on embedded devices.In order to reduce the complexity and overhead of deploying neural networks on Integeronly hardware,most current quantization methods use a symmetric quantization mapping strategy to quantize a floating-point neural network into an integer network.However,although symmetric quantization has the advantage of easier implementation,it is sub-optimal for cases where the range could be skewed and not symmetric.This often comes at the cost of lower accuracy.This paper proposed an activation redistribution-based hybrid asymmetric quantizationmethod for neural networks.The proposedmethod takes data distribution into consideration and can resolve the contradiction between the quantization accuracy and the ease of implementation,balance the trade-off between clipping range and quantization resolution,and thus improve the accuracy of the quantized neural network.The experimental results indicate that the accuracy of the proposed method is 2.02%and 5.52%higher than the traditional symmetric quantization method for classification and detection tasks,respectively.The proposed method paves the way for computationally intensive neural network models to be deployed on devices with limited computing resources.Codes will be available on https://github.com/ycjcy/Hybrid-Asymmetric-Quantization.
文摘AIM: To observe the therapeutic effects of liposomeencapsulated adriamycin (LADM) on hepatoma in comparison with adriamycin solution (FADM) and adriarnycin plus blank liposome (ADM + BL) administered into the hepatic artery of rats. METHODS: LADM was prepared by pH gradient-driven method. Normal saline, FADM (2 mg/kg), ADM+BL (2 mg/kg), and LADM (2 mg/kg) were injected via the hepatic artery in rats bearing liver W256 carcinosarcoma, which were divided into four groups randomly. The therapeutic effects were evaluated in terms of survival time, tumor enlargement ratio, and tumor necrosis degree. The difference was determined with ANOVA and Dunnett test and log rank test. RESULTS: Compared to FADM or ADM + BL, LADM produced a more significant tumor inhibition (tumor volume ratio: 1.243±0.523 vs 1.883±0.708, 1.847±0.661, P 〈 0.01), and more extensive tumor necrosis. The increased life span was prolonged significantly in rats receiving LADM compared with FADM or ADM+BL (231.48 vs 74.66, 94.70) (P 〈 0.05). CONCLUSION: The anticancer efficacies of adriamycin on hepatoma can be strongly improved by liposomal encapsulation through hepatic arterial administration.
基金supported by the China Postdoctoral Science Foundation(2020M681503)Foundation of State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering(2021-K56).
文摘As an industrial solid waste,pyrite cinder exhibited excellent reactivity and cycle stability in chemical looping combustion.Prior to the experiment,oxygen carriers often experienced a high temperature calcination process to stabilize the physico-chemical properties,which presented significant influence on the redox performance of oxygen carriers.However,the effect of calcination temperature on the cyclic reaction performance of pyrite cinder has not been studied in detail.In this work,the effect of calcination temperature on the redox activity and attrition characteristic of pyrite cinder were studied in a fluidizedbed reactor using CH_(4) as fuel.A series of pyrite cinder samples were prepared by controlling the calcination temperature.The redox activity and attrition rate of the obtained pyrite cinder samples were investigated deeply.The results showed that calcination temperature displayed significant impact on the redox performance of pyrite cinder.Considering CH_(4) conversion(80%–85%)and attrition resistance,the pyrite cinder calcined at 1050℃ presented excellent redox properties.In the whole experiment process,the CO_(2) selectivity of the pyrite cinder samples were not affected by the calcination temperature and were still close to 100%.The results can provide reference for optimizing the calcination temperature of pyrite cinder during chemical looping process.
基金supported by the Program for High-Level Entrepreneurial and Innovative Talents Introduction of Jiangsu ProvinceFoundation of State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering(2021-K56)+1 种基金Foundation of Key Laboratory of Energy Thermal Conversion and Control of Ministry of EducationSenior Talent Foundation of Jiangsu University(20JDG40)。
文摘Chemical looping combustion(CLC)is a clean and efficient flame-free combustion technology,which combust the fuels by lattice oxygen from a solid oxygen carrier with inherent CO_(2)capture.The development of oxygen carriers with low cost and high redox performance is crucial to the whole efficiency of CLC process.As the solid by-product from the sulfuric acid production,pyrite cinder presented excellent redox performance as an oxygen carrier in CLC process.The main components in pyrite cinder are Fe_(2)O_(3),CaSO_(4),Al_(2)O_(3)and SiO_(2)in which Fe_(2)O_(3)is the active component to provide lattice oxygen.In order to systematic investigate the functions of supports(CaSO_4,Al_(2)O_(3)and SiO_(2))in pyrite cinder,three oxygen carriers(Fe_(2)O_(3)-CaSO_(4),Fe_(2)O_(3)-Al_(2)O_(3)and Fe_(2)O_(3)-SiO_(2))were prepared and evaluated in this study.The results showed that Fe_(2)O_(3)-CaSO_(4) displayed high redox activity and cycling stability in the multiple redox cycles.However,both Fe_(2)O_(3)-Al_(2)O_(3)and Fe_(2)O_(3)-SiO_(2)experienced serious deactivation during redox reactions.It indicated that the inert Fe-Si solid solution(Fe_(2)SiO_(4))was formed in the spent Fe_(2)O_(3)-SiO_(2)sample,which decreased the oxygen carrying capacity of this sample.The XPS results showed that the oxygen species on the surface of Fe_(2)O_(3)-CaSO_(4) could be fully recovered after the 20 redox cycles.It can be concluded that CaSO_(4) is the key to the high redox activity and cycling stability of pyrite cinder.
基金the National Natural Science Foundation of China under Grants 61825403,61674078,and 61921005the National Key Research and Development program of China under Grant 2017YFA0206302, the PAPD program.
文摘Current electronics are driven by advanced microfabrication for fast and efficient information processing.In spite of high performance,these wafer-based devices are rigid,non-degradable,and unable to autonomous repair.Skin-inspired electronics have emerged as a new class of devices and systems for next-generation flexible and wearable electronics.The technology gains inspiration from the structures,properties,and sensing mechanisms of the skin,which may find a broad range of applications in cutting-edge fields such as healthcare monitoring,human-machine interface,and soft robotics/prostheses.Practical demands have fueled the development of electronic materials with skin-like properties in terms of stretchability,self-healing capability,and biodegradability.These materials provide the basis for functional sensors with innovative and biomimetic designs.Further system-level integrations and optimizations enable new forms of electronics for real-world applications.This review summarizes recent advancements in this active area and speculates on future directions.
文摘Electronic skin(e-skin),a kind of flexible sensor arrays and system that mimic the properties and sensing functions of human skin,represents a new paradigm of sensing and control(Fig.1).The noun of'skin electronics'made its debut in the Sensitive Skin Workshop organized jointly by the National Science Foundation and Defense Advanced Research Projects Agency of USA in October 1999 in Arlington.
基金the National Key Research and Development Program of China(No.2020YFA0211004)National Natural Science Foundation of China(Nos.21876112,21876113,22022608)+1 种基金Shanghai Engineering Research Center of Green Energy Chemical Engineering and Shanghai Government(No.18SG41)“111”Innovation and Talent Recruitment Base on Photo-chemical and Energy Materials(No.D18020).
文摘The emission of nitrogen oxides(NO_(x))increases year by year,causing serious problems to our livelihoods.The photocatalytic oxidation of NO_(x)has attracted more attention recently because of its effi cient removal of NO_(x),especially for low concentra-tions of NO_(x).In this review,the mechanism of the photocatalytic oxidation of NO_(x)is described.Then,the recent progress on the development of photocatalysts is reviewed according to the categories of inorganic semiconductors,bismuth-based compounds,nitrogen carbide polymer,and metal organic frameworks(MOFs).In addition,the photoelectrocatalytic oxida-tion of NO_(x),a method involving the application of an external voltage on the photocatalytic system to further increase the removal effi ciency of NO_(x),and its progress are summarized.Finally,we outline the remaining challenges and provide our perspectives on the future directions for the photocatalytic oxidation of NO_(x).
基金the financial support of this work by the National Natural Science Foundation of China (No.21406139)the Development Project of University of Shanghai for Science and Technology (No.2019KJFZ019)+1 种基金the Scientific Research Innovation Project of Shanghai Education Commission (No.2019-01-07-0007-E00015)the Basic Research Project (No.19JC1410402)。
文摘Metal-free heteroatoms dual-doped carbon has been recognized as one of the most promising Pt/C-substitutes for oxygen reduction reaction(ORR).Herein,we optimize the preparation process by doping order of metal-free heteroatoms to obtain the best electrocatalytic performance through three types of dual-doped carbon,including XC-N(first X doping then N doping),NC-X(first N doping then X doping) and NXC(N and X doping)(X=P,S and F).XC-N has more defect than the other two indicated by Raman spectra.X-ray photoelectron spectrom(XPS) measurements indicate that N and X have been dual-doped into the carbon matrix with different doping contents and modes,Electrocatalytic results,including the potential of ORR peak(Ep),the half-wave potential,the diffusion-limiting current density mainly follows the order of XC-N>NC-X> NXC,Furthermore,the synergistic effect of second atom doping are also compared with the single doped carbon(NC,PC,SC and FC).The differences in electronegativity and atomic radius of these metal-free heteroatoms can affect the defect degree,the doping content and mode of hete roatoms on carbon matrix,induce polarization effect and space effect to affect O2 adsorption and product desorption,ultimately to the ORR electrocatalytic performance.
基金supported by the Truman State University Math Bio Programthe National Science Foundation, USA (Nos. 0436348 and 0337769)
文摘Phosphorus (P) is a major limiting factor for plant productivity in many ecosystems and agriculture. The projected increase in atmospheric CO2 is likely to result in changes in plant mineral consumption and growth. We studied P depletion by common bean (Phaseolus vulgaris) cultured hydroponically under ambient (377±77μmol mol^-1) or elevated (650±32 μmol mol^-1) CO2 in media of low or high P. Under elevated CO2 compared to ambient CO2, the maximum P depletion rate increased by 98% at low P and 250% at high P, and P was depleted about 2-5 weeks sooner; leaf acid phosphatase (APase) activity and chlorophyll content both increased significantly; root-to-shoot ratio increased significantly at high P, although it was unaffected at low P; lateral root respiration rate showed no change, suggesting that COs did not affect P depletion via metabolic changes to the roots; the total biomass at final harvest was significantly higher at both low and high P. Our data showed that the increased rate and amount of P depletion during plant growth under elevated CO2 occurred in association with alterations in leaf biochemical properties, i.e., enhanced activities of leaf APase and increased leaf chlorophyll content.