BACKGROUND At present,understanding of the most effective ventilation methods for treating chronic obstructive pulmonary disease(COPD)patients experiencing acute worsening symptoms and respiratory failure remains rela...BACKGROUND At present,understanding of the most effective ventilation methods for treating chronic obstructive pulmonary disease(COPD)patients experiencing acute worsening symptoms and respiratory failure remains relatively limited.This report analyzed the efficiency and side effects of various ventilation techniques used for individuals experiencing an acute COPD exacerbation.AIM To determine whether pressure-controlled ventilation(PCV)can lower peak airway pressures(PAPs)and reduce the incidence of barotrauma compared to volume-controlled ventilation(VCV),without compromising clinical outcomes and oxygenation parameters.METHODS We have evaluated 600 patients who were hospitalized due to a severe COPD exacerbation,with 400 receiving mechanical ventilation for the respiratory failure.The participants were divided into two different groups,who were administered either VCV or PCV,along with appropriate management.We thereafter observed patients'attributes,clinical factors,and laboratory,radiographic,and arterial blood gas evaluations at the start and during their stay in the intensive care unit(ICU).We have also employed appropriate statistical methods for the data analysis.RESULTS Both the VCV and PCV groups experienced significant enhancements in the respiratory rate,tidal volume,and arterial blood gas values during their time in the ICU.However,no significant distinctions were detected between the groups in terms of oxygenation indices(partial pressures of oxygen/raction of inspired oxygen ratio)and partial pressures of carbon dioxide improvements.There was no considerable disparity observed between the VCV and PCV groups in the hospital mortality(32%vs 28%,P=0.53),the number of days of ICU stay[median interquartile range(IQR):9(6-14)d vs 8(5-13)d,P=0.41],or the duration of the mechanical ventilation[median(IQR):6(4-10)d vs 5(3-9)d,P=0.47].The PCV group displayed lower PAPs compared to the VCV group(P<0.05)from the beginning of mechanical ventilation until extubation or ICU departure.The occurrence of barotrauma was considerably lower in the PCV group in comparison to the VCV group(6%vs 16%,P=0.03).CONCLUSION Both VCV and PCV were found to be effective in treating patients with acute COPD exacerbation.However,PCV was associated with lower PAPs and a significant decrease in barotrauma,thus indicating that it might be a safer ventilation method for this group of patients.However,further large-scale study is necessary to confirm these findings and to identify the best ventilation approach for patients experiencing an acute COPD exacerbation.展开更多
BACKGROUND^(14)C urea breath test(^(14)C UBT)and immunohistochemical staining(IHC)are widely used for detection Helicobacter pylori(H.pylori)infection with different sensitivity,and there is a difference in H.pylori i...BACKGROUND^(14)C urea breath test(^(14)C UBT)and immunohistochemical staining(IHC)are widely used for detection Helicobacter pylori(H.pylori)infection with different sensitivity,and there is a difference in H.pylori infection rate in Uyghur and Han ethnic groups.Both need large cohort studies to evaluate the differences more accurately.AIM To analyze the difference between^(14)C UBT and IHC for H.pylori detection in Xinjiang Uyghur Autonomous Region and the difference between Uyghur and Han populations.METHODS There were 3944 cases of H.pylori infection detected by both IHC and^(14)C UBT at the same time(interval<1 wk,with sampling site including gastric antrum,selected from 5747 patients).We compared the sensitivity of^(14)C UBT and IHC.We also compared 555 pairs of Han/Uyghur cases(completely matched for gender and age)for their H.pylori infection rates.The overall H.pylori infection rate of all 5747 cases and the correlation with other clinicopathological data were also further analyzed.SPSS V23.0 software was used for statistical analysis.RESULTS The sensitivity was 94.9%for^(14)C UBT and 65.1%for IHC,which was a significant difference(n=3944,P<0.001).However,among those cases negative for H.pylori by^(14)C UBT(detection value≤100),4.8%were positive by IHC.Combining both methods,the overall H.pylori infection rate was 48.6%(n=5747),and differences in gender,age group,ethnicity and region of residence significantly affected the H.pylori positive rates.According to age group(Han/Uyghur),the positive rates were≤30 years(62.2%/100.0%),31-40 years(45.2%/85.7%),41-50 years(47.2%/79.2%),51-60 years(44.6%/76.1%),61-70 years(40.9%/68.2%),71-80 years(41.7%/54.1%)and≥81 years(42.9%/NA).The H.pylori infection rates of Han/Uyghur paired cases were 41.4%and 73.3%,which was a significant difference(P<0.001)(555 pairs).H.pylori positivity was significantly related to moderate-severe grade 2-3 chronic/active gastritis and intestinal metaplasia(all P<0.05).CONCLUSION The sensitivity of^(14)C UBT was significantly higher,but combined application can still increase the accuracy.The prevention H.pylori should be emphasized for Uygur and young people.展开更多
Background Mixed reality(MR)video fusion systems merge video imagery with 3D scenes to make the scene more realistic and help users understand the video content and temporal–spatial correlation between them,reducing ...Background Mixed reality(MR)video fusion systems merge video imagery with 3D scenes to make the scene more realistic and help users understand the video content and temporal–spatial correlation between them,reducing the user′s cognitive load.MR video fusion are used in various applications;however,video fusion systems require powerful client machines because video streaming delivery,stitching,and rendering are computationally intensive.Moreover,huge bandwidth usage is another critical factor that affects the scalability of video-fusion systems.Methods Our framework proposes a fusion method for dynamically projecting video images into 3D models as textures.Results Several experiments on different metrics demonstrate the effectiveness of the proposed framework.Conclusions The framework proposed in this study can overcome client limitations by utilizing remote rendering.Furthermore,the framework we built is based on browsers.Therefore,the user can test the MR video fusion system with a laptop or tablet without installing any additional plug-ins or application programs.展开更多
目的分析维生素D辅助股骨近端防旋髓内钉(proximal femoral nail anti-rotation,PFNA)内固定治疗老年股骨转子间骨折的远期疗效。方法选取2018年1月至2019年6月四川大学华西医院骨科收治的老年股骨转子间骨折患者60例为研究对象,按照随...目的分析维生素D辅助股骨近端防旋髓内钉(proximal femoral nail anti-rotation,PFNA)内固定治疗老年股骨转子间骨折的远期疗效。方法选取2018年1月至2019年6月四川大学华西医院骨科收治的老年股骨转子间骨折患者60例为研究对象,按照随机数字表法将其分为对照组和研究组,每组各30例。研究组患者采取维生素D辅助PFNA内固定治疗,对照组患者采取PFNA内固定治疗。随访1年,比较两组患者治疗总有效率、简明健康状况调查表(short-form health survey-36,SF-36量表)评分、Harris髋关节评分(Harris hip score,HHS)及血清骨形态发生蛋白质-7(bone morphogenetic protein-7,BMP-7)、25-羟维生素D3[25-hydroxyvitamin D3,25(OH)D3]水平。结果治疗后12个月,研究组患者治疗总有效率显著高于对照组(χ^2=4.320,P=0.038);两组患者SF-36量表各项评分均显著高于本组治疗前(均P<0.05),且研究组患者上述评分均显著高于对照组(均P<0.01)。治疗后1、2、3、6、12个月,研究组患者HHS、血清BMP-7和25(OH)D3水平均显著高于同期对照组(均P<0.05)。随着随访时间的延长,研究组患者HHS、血清BMP-7和25(OH)D3水平升高幅度均显著大于对照组(均P<0.05)。结论维生素D辅助PFNA内固定能够明显提高老年股骨转子间骨折患者血清BMP-7和25(OH)D3水平,对改善髋关节功能具有良好的远期疗效。展开更多
文摘BACKGROUND At present,understanding of the most effective ventilation methods for treating chronic obstructive pulmonary disease(COPD)patients experiencing acute worsening symptoms and respiratory failure remains relatively limited.This report analyzed the efficiency and side effects of various ventilation techniques used for individuals experiencing an acute COPD exacerbation.AIM To determine whether pressure-controlled ventilation(PCV)can lower peak airway pressures(PAPs)and reduce the incidence of barotrauma compared to volume-controlled ventilation(VCV),without compromising clinical outcomes and oxygenation parameters.METHODS We have evaluated 600 patients who were hospitalized due to a severe COPD exacerbation,with 400 receiving mechanical ventilation for the respiratory failure.The participants were divided into two different groups,who were administered either VCV or PCV,along with appropriate management.We thereafter observed patients'attributes,clinical factors,and laboratory,radiographic,and arterial blood gas evaluations at the start and during their stay in the intensive care unit(ICU).We have also employed appropriate statistical methods for the data analysis.RESULTS Both the VCV and PCV groups experienced significant enhancements in the respiratory rate,tidal volume,and arterial blood gas values during their time in the ICU.However,no significant distinctions were detected between the groups in terms of oxygenation indices(partial pressures of oxygen/raction of inspired oxygen ratio)and partial pressures of carbon dioxide improvements.There was no considerable disparity observed between the VCV and PCV groups in the hospital mortality(32%vs 28%,P=0.53),the number of days of ICU stay[median interquartile range(IQR):9(6-14)d vs 8(5-13)d,P=0.41],or the duration of the mechanical ventilation[median(IQR):6(4-10)d vs 5(3-9)d,P=0.47].The PCV group displayed lower PAPs compared to the VCV group(P<0.05)from the beginning of mechanical ventilation until extubation or ICU departure.The occurrence of barotrauma was considerably lower in the PCV group in comparison to the VCV group(6%vs 16%,P=0.03).CONCLUSION Both VCV and PCV were found to be effective in treating patients with acute COPD exacerbation.However,PCV was associated with lower PAPs and a significant decrease in barotrauma,thus indicating that it might be a safer ventilation method for this group of patients.However,further large-scale study is necessary to confirm these findings and to identify the best ventilation approach for patients experiencing an acute COPD exacerbation.
文摘BACKGROUND^(14)C urea breath test(^(14)C UBT)and immunohistochemical staining(IHC)are widely used for detection Helicobacter pylori(H.pylori)infection with different sensitivity,and there is a difference in H.pylori infection rate in Uyghur and Han ethnic groups.Both need large cohort studies to evaluate the differences more accurately.AIM To analyze the difference between^(14)C UBT and IHC for H.pylori detection in Xinjiang Uyghur Autonomous Region and the difference between Uyghur and Han populations.METHODS There were 3944 cases of H.pylori infection detected by both IHC and^(14)C UBT at the same time(interval<1 wk,with sampling site including gastric antrum,selected from 5747 patients).We compared the sensitivity of^(14)C UBT and IHC.We also compared 555 pairs of Han/Uyghur cases(completely matched for gender and age)for their H.pylori infection rates.The overall H.pylori infection rate of all 5747 cases and the correlation with other clinicopathological data were also further analyzed.SPSS V23.0 software was used for statistical analysis.RESULTS The sensitivity was 94.9%for^(14)C UBT and 65.1%for IHC,which was a significant difference(n=3944,P<0.001).However,among those cases negative for H.pylori by^(14)C UBT(detection value≤100),4.8%were positive by IHC.Combining both methods,the overall H.pylori infection rate was 48.6%(n=5747),and differences in gender,age group,ethnicity and region of residence significantly affected the H.pylori positive rates.According to age group(Han/Uyghur),the positive rates were≤30 years(62.2%/100.0%),31-40 years(45.2%/85.7%),41-50 years(47.2%/79.2%),51-60 years(44.6%/76.1%),61-70 years(40.9%/68.2%),71-80 years(41.7%/54.1%)and≥81 years(42.9%/NA).The H.pylori infection rates of Han/Uyghur paired cases were 41.4%and 73.3%,which was a significant difference(P<0.001)(555 pairs).H.pylori positivity was significantly related to moderate-severe grade 2-3 chronic/active gastritis and intestinal metaplasia(all P<0.05).CONCLUSION The sensitivity of^(14)C UBT was significantly higher,but combined application can still increase the accuracy.The prevention H.pylori should be emphasized for Uygur and young people.
基金Supported by the National Key R&D Program of China(2018YFB2100601)National Natural Science Foundation of China(61872024)。
文摘Background Mixed reality(MR)video fusion systems merge video imagery with 3D scenes to make the scene more realistic and help users understand the video content and temporal–spatial correlation between them,reducing the user′s cognitive load.MR video fusion are used in various applications;however,video fusion systems require powerful client machines because video streaming delivery,stitching,and rendering are computationally intensive.Moreover,huge bandwidth usage is another critical factor that affects the scalability of video-fusion systems.Methods Our framework proposes a fusion method for dynamically projecting video images into 3D models as textures.Results Several experiments on different metrics demonstrate the effectiveness of the proposed framework.Conclusions The framework proposed in this study can overcome client limitations by utilizing remote rendering.Furthermore,the framework we built is based on browsers.Therefore,the user can test the MR video fusion system with a laptop or tablet without installing any additional plug-ins or application programs.
文摘目的分析维生素D辅助股骨近端防旋髓内钉(proximal femoral nail anti-rotation,PFNA)内固定治疗老年股骨转子间骨折的远期疗效。方法选取2018年1月至2019年6月四川大学华西医院骨科收治的老年股骨转子间骨折患者60例为研究对象,按照随机数字表法将其分为对照组和研究组,每组各30例。研究组患者采取维生素D辅助PFNA内固定治疗,对照组患者采取PFNA内固定治疗。随访1年,比较两组患者治疗总有效率、简明健康状况调查表(short-form health survey-36,SF-36量表)评分、Harris髋关节评分(Harris hip score,HHS)及血清骨形态发生蛋白质-7(bone morphogenetic protein-7,BMP-7)、25-羟维生素D3[25-hydroxyvitamin D3,25(OH)D3]水平。结果治疗后12个月,研究组患者治疗总有效率显著高于对照组(χ^2=4.320,P=0.038);两组患者SF-36量表各项评分均显著高于本组治疗前(均P<0.05),且研究组患者上述评分均显著高于对照组(均P<0.01)。治疗后1、2、3、6、12个月,研究组患者HHS、血清BMP-7和25(OH)D3水平均显著高于同期对照组(均P<0.05)。随着随访时间的延长,研究组患者HHS、血清BMP-7和25(OH)D3水平升高幅度均显著大于对照组(均P<0.05)。结论维生素D辅助PFNA内固定能够明显提高老年股骨转子间骨折患者血清BMP-7和25(OH)D3水平,对改善髋关节功能具有良好的远期疗效。
