To the Editor:Central pontine myelinolysis(CPM),a form of osmotic demyelination syndrome(ODS)typically-occurring in the central pons,was first described in alcoholic and malnourished individuals by Adams et al[1]in 19...To the Editor:Central pontine myelinolysis(CPM),a form of osmotic demyelination syndrome(ODS)typically-occurring in the central pons,was first described in alcoholic and malnourished individuals by Adams et al[1]in 1959.ODS is frequently associated with alcohol abuse,liver transplantation,and rapid correction of hyponatremia.[2]The clinical manifestations of CPM are variable,including dysarthria,dysphagia,oculomotor dysfunction,variable degrees of quadriparesis and even locked-in syndrome.addition,some patients may be asymptomatic.The size of myelinolysis in the central pons on brain magnetic resonance imaging(MRI)is not always matched with the severity of clinical symptoms.Previously,a limited number of case reports focued on the magnetic resonance spectroscopy(MRS)findings of CPM.展开更多
文摘To the Editor:Central pontine myelinolysis(CPM),a form of osmotic demyelination syndrome(ODS)typically-occurring in the central pons,was first described in alcoholic and malnourished individuals by Adams et al[1]in 1959.ODS is frequently associated with alcohol abuse,liver transplantation,and rapid correction of hyponatremia.[2]The clinical manifestations of CPM are variable,including dysarthria,dysphagia,oculomotor dysfunction,variable degrees of quadriparesis and even locked-in syndrome.addition,some patients may be asymptomatic.The size of myelinolysis in the central pons on brain magnetic resonance imaging(MRI)is not always matched with the severity of clinical symptoms.Previously,a limited number of case reports focued on the magnetic resonance spectroscopy(MRS)findings of CPM.
