BACKGROUND Breast cancer(BCa)is one of the most common malignancies in women;however,ureteral metastasis of BCa has rarely been reported in the literature.CASE SUMMARY A 55-year-old Chinese woman with an 8-year histor...BACKGROUND Breast cancer(BCa)is one of the most common malignancies in women;however,ureteral metastasis of BCa has rarely been reported in the literature.CASE SUMMARY A 55-year-old Chinese woman with an 8-year history of BCa presented with lower back pain that had persisted for 3 mo.The patient underwent bilateral modified radical mastectomy and subclavian and submandibular clearance,and received systemic treatment,including chemotherapy,radiotherapy,and targeted therapy during treatment.Ureteroscopy did not acquire a satisfactory biopsy.Thus,laparoscopic nephroureterectomy was performed,and ureteral metastases of BCa were pathologically confirmed.As suggested by her oncologist,she continued to receive apatinib.Postoperative 3-mo follow-up indicated further progression of axillary lymph node metastases.CONCLUSION Ureteral metastasis of BCa shows nonspecific symptoms.Diagnosing ureter metastasis from BCa can be established by histopathology and immunohistochemistry.展开更多
Here,we developed a prostate cancer(PCa)risk nomogram including lymphocyte-to-monocyte ratio(LMR)for initial prostate biopsy,and internal and external validation were further conducted.A prediction model was developed...Here,we developed a prostate cancer(PCa)risk nomogram including lymphocyte-to-monocyte ratio(LMR)for initial prostate biopsy,and internal and external validation were further conducted.A prediction model was developed on a training set.Significant risk factors with P<0.10 in multivariate logistic regression models were used to generate a nomogram.Discrimination,calibration,and clinical usefulness of the model were assessed using C-index,calibration plot,and decision curve analysis(DCA).The nomogram was re-examined with the internal and external validation set.A nomogram predicting PCa risk in patients with prostate-specific antigen(PSA)4-10 ng ml^(-1)was also developed.The model displayed good discrimination with C-index of 0.830(95%confidence interval[Cl]:0.812-0.852).High C-index of 0.864(95%Cl:0.840-0.888)and 0.871(95%Cl:0.861-0.881)was still reached in the internal and external validation sets,respectively.The nomogram exhibited better performance compared to the nomogram with PSA only(C-index:0.763,95%Cl:0.746-0.780,P<0.001)and the nomogram with LMR excluded(C-index:0.824,95%Cl:0.804-0.844,P<0.010).The calibration curve demonstrated good agreement in the internal and external validation sets.DCA showed that the nomogram was useful at the threshold probability of>4%and<99%.The nomogram predicting PCa risk in patients with PSA 4-10 ng ml^(-1)also displayed good calibration and discrimination performance(C-index:0.734,95%Cl:0.708-0.760).This nomogram incorporating age,PSA,digital rectal examination,abnormal imaging signals,PSA density,and LMR could be used to facilitate individual PCa risk prediction in initial prostate biopsy.展开更多
基金Supported by the National Natural Science Foundation of China,No.81502195 and No.81672512
文摘BACKGROUND Breast cancer(BCa)is one of the most common malignancies in women;however,ureteral metastasis of BCa has rarely been reported in the literature.CASE SUMMARY A 55-year-old Chinese woman with an 8-year history of BCa presented with lower back pain that had persisted for 3 mo.The patient underwent bilateral modified radical mastectomy and subclavian and submandibular clearance,and received systemic treatment,including chemotherapy,radiotherapy,and targeted therapy during treatment.Ureteroscopy did not acquire a satisfactory biopsy.Thus,laparoscopic nephroureterectomy was performed,and ureteral metastases of BCa were pathologically confirmed.As suggested by her oncologist,she continued to receive apatinib.Postoperative 3-mo follow-up indicated further progression of axillary lymph node metastases.CONCLUSION Ureteral metastasis of BCa shows nonspecific symptoms.Diagnosing ureter metastasis from BCa can be established by histopathology and immunohistochemistry.
基金This study was partly funded by the National Natural Science Foundation of China(No.81502195).
文摘Here,we developed a prostate cancer(PCa)risk nomogram including lymphocyte-to-monocyte ratio(LMR)for initial prostate biopsy,and internal and external validation were further conducted.A prediction model was developed on a training set.Significant risk factors with P<0.10 in multivariate logistic regression models were used to generate a nomogram.Discrimination,calibration,and clinical usefulness of the model were assessed using C-index,calibration plot,and decision curve analysis(DCA).The nomogram was re-examined with the internal and external validation set.A nomogram predicting PCa risk in patients with prostate-specific antigen(PSA)4-10 ng ml^(-1)was also developed.The model displayed good discrimination with C-index of 0.830(95%confidence interval[Cl]:0.812-0.852).High C-index of 0.864(95%Cl:0.840-0.888)and 0.871(95%Cl:0.861-0.881)was still reached in the internal and external validation sets,respectively.The nomogram exhibited better performance compared to the nomogram with PSA only(C-index:0.763,95%Cl:0.746-0.780,P<0.001)and the nomogram with LMR excluded(C-index:0.824,95%Cl:0.804-0.844,P<0.010).The calibration curve demonstrated good agreement in the internal and external validation sets.DCA showed that the nomogram was useful at the threshold probability of>4%and<99%.The nomogram predicting PCa risk in patients with PSA 4-10 ng ml^(-1)also displayed good calibration and discrimination performance(C-index:0.734,95%Cl:0.708-0.760).This nomogram incorporating age,PSA,digital rectal examination,abnormal imaging signals,PSA density,and LMR could be used to facilitate individual PCa risk prediction in initial prostate biopsy.
