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Thermodynamic Resolution of Pharmaceutical Precursor Modafinil Acid on the Basis of Chiral-at-Metal Strategy
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作者 Man-Li Cao Jun-Ling Zhu +3 位作者 zhong-lan zhi Bao-Hui Ye Su-Yang Yao Xiu-Lian Zhang 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2021年第6期1483-1490,共8页
Chiral-at-metal strategy was developed to resolve the essential sulfoxide pharmaceutical intermediates R-modafinil acid and its ana-logues with high yields and ee values.The efficient resolution process was achieved b... Chiral-at-metal strategy was developed to resolve the essential sulfoxide pharmaceutical intermediates R-modafinil acid and its ana-logues with high yields and ee values.The efficient resolution process was achieved based on the diastereoselective discrimination caused by hydrogen bond and intramolecular π-π interaction between chiral-at-metal center and the coordinated chiral sulfoxide ligands.Moreover,the chiral Ir(lll)receptor can be reused with complete retention of their configurations and without the loss of reaction activity and enantioselectivity.This work provides a new access to synthesize R-modafinil acid as well as its analogues and develops the application of chiral-at-metal strategy in chiral resolution. 展开更多
关键词 Chiral resolution Chiral-at-metal complexes Modafinil acid Chiral pharmaceutical Ir(III)complexes
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