Objective:To explore the characteristics of ZHANG Zhongjing's medication for constipation by analyzing the prescriptions of treatise on Shanghan Lun and Jingui Yaolue.Methods:the formulations that met the inclusio...Objective:To explore the characteristics of ZHANG Zhongjing's medication for constipation by analyzing the prescriptions of treatise on Shanghan Lun and Jingui Yaolue.Methods:the formulations that met the inclusion criteria were selected to establish a database,and the regularity of ZHANG Zhongjing's medication for constipation was analyzed by the methods of frequency,association rules and clustering.Results:In this study,11 prescriptions and 24 medicines were included.High-frequency use of drugs rhubarb,licorice,CortexMagnoliae Officinalis,fructus aurantii immaturus,mirabilis,ginger,jujube,white atractylodes rhizome,cassia twig,Chinese herbaceous peony.A total of 17 association rules(11 rules for 2 drugs and 6 rules for 3 drugs)were obtained by mining,including"Rhubarb+Mirabilite","fructus aurantii immaturus+Cortex Magnoliae Officinalis","Rhubarb+Cortex Magnoliae Officinalis","Rhubarb+Cortex Magnoliae Officinalis+fructus aurantii immaturus",and so on,and 7 groups of drug pair association group and 2 groups of multi-flavor drug association group were obtained.Network link analysis shows that there are 7 groups of strong link compatibility.Medium link compatibility 46 groups.Cluster analysis obtained 14 groups,including 8 single-taste drug groups,3 drug-pair polymerization groups and 3 multi-taste drug polymerization groups.Conclusions:ZHANG Zhongjing is not only good at using purgative medicine in treating constipation treating constipation,but also pays attention to invigorating qi and activating blood circulation,resolving the surface and regulating dampness,soothing the liver and regulating qi.展开更多
Pomalidomide is an immunomodulatory agent (IMiD) that has been approved by the US Food and Drug Administration (FDA) for clinical treatment of patients with multiple myeloma.In this work,we developed a sensitive and v...Pomalidomide is an immunomodulatory agent (IMiD) that has been approved by the US Food and Drug Administration (FDA) for clinical treatment of patients with multiple myeloma.In this work,we developed a sensitive and validated LC-MS/MS method for high-throughput determination of pomalidomide over the range of 1.006-100.6 ng/mL(R^(2)=0.9991) in human plasma and pharmacokinetic studies.A liquid-liquid extraction method using ethyl acetate was applied to extract pomalidomide and afatinib (as an internal standard,IS) from human plasma.Chromatographic separation was performed on a Hedera ODS column (150 mm×2.1 mm,5μm) with security guard C18 column (4 mm×2.0 mm) at 40℃.Methanol and 10 mmol/L aqueous solution of ammonium acetate containing 0.1%formic acid were used as a gradient elution mobile phase,and the flow rate was 0.4 mL/min.A triple quadruple tandem mass spectrometer using multiplex reaction monitoring mode (MRM) with electrospray ionization (ESI) positive ionization was employed.The precursor to product ion transitions for the quantitative analysis of pomalidomide and the IS were m/z 274.2→163.1 and m/z 486.1→371.1,respectively.This established method has been validated according to regulatory guideline,and the results were all within the acceptance criteria.The validated LC-MS/MS method was successfully applied to analyze samples obtained from clinical pharmacokinetics study after oral administration of pomalidomide (4 mg) capsules in human.展开更多
Materials with efficient circularly polarized phosphorescences(CPPs) are of potential use in advanced data encryption and anticounterfeiting, bioimaging, optoelectronic devices and so forth. Herein, a simple method is...Materials with efficient circularly polarized phosphorescences(CPPs) are of potential use in advanced data encryption and anticounterfeiting, bioimaging, optoelectronic devices and so forth. Herein, a simple method is presented for the preparations of CPP-active micro/nanocrystals with large luminescence dissymmetry factors(glum), high phosphorescence quantum efficiencies(Φ_(P)) and tunable emission colors. Diastereomeric Ir^(Ⅲ) and Ru^(Ⅱ) complexes with chiral(±)-camphorsulfonate counter-anions are readily synthesized and assembled into crystalline microrods, microplates or nanofibers with ordered morphologies. The chirality information of chiral counter-anions is efficiently transferred to the metal components to afford CPPs with cyan, green,yellow, or red emission colors and Φ_(P)in the range of 5%–85%. The number of chiral anions is found to play a role in influencing the CPP magnitudes of these crystals. The dicationic Ru^(Ⅱ) and tricationic Ir^(Ⅲ) complexes show glumvalues in the 10^(-2)order, which are much larger with respect to those of monocationic Ir^(Ⅲ) complexes. Single crystal X-ray analysis is performed to obtain information on the chirality transfer of these materials. In addition, circularly polarized photonic signal waveguiding is demonstrated using the microcrystals of an Ir^(Ⅲ)complex. This work demonstrates an appealing strategy of constructing chiral micro/nano-architectures for potential applications in chiral nanophotonics.展开更多
Water behavior in nanoconfined hydrophobic environment is different from that in the bulk,which greatly influences mass transport.Hydrophobicity switching of nanopores showing great potential for controlled water or i...Water behavior in nanoconfined hydrophobic environment is different from that in the bulk,which greatly influences mass transport.Hydrophobicity switching of nanopores showing great potential for controlled water or ion transport has been realized through several methods,especially the voltage-triggered wetting/dewetting inspired by biological ion channels.However,in the hydrophobic silanized nanopores,the finite ionic current is still observed and the ion transport mechanism is not yet clear.Here,we explore the ion transport behavior in the hydrophobic silanized anodic aluminum oxide(AAO).Ion transport through this hydrophobic membrane is confirmed,although no aqueous pathway was observed.Results show that ions transport through the cross-linked silane layer on the inner surface.It is revealed that metal ions,not just the protons or hydroxide ions,are involved in the ion transport driven by external electric field.This study provides a new insight into the ion transport in nanoconfined hydrophobic environment which is helpful to understand the biological processes and design new nanofluidic devices.展开更多
Harvesting the low-grade(<100°C)solar thermal energy with ionic heat-to-electricity conversion shows great promise but low efficiencies due to the challenges encountered in regulating ionic thermophoretic mobi...Harvesting the low-grade(<100°C)solar thermal energy with ionic heat-to-electricity conversion shows great promise but low efficiencies due to the challenges encountered in regulating ionic thermophoretic mobilities.Here,we used nanochannels to regulate thermal-driven ion transport properties and described a solar thermoelectric nanofluidic device(STEND).展开更多
The development and applications of materials with efficient circularly polarized luminescence(CPL)have become an interdisciplinary frontier research topic.We summarize herein the recent advance in the development and...The development and applications of materials with efficient circularly polarized luminescence(CPL)have become an interdisciplinary frontier research topic.We summarize herein the recent advance in the development and applications of CPLactive aggregates based on metal-ligand coordination materials(termed as“coordination aggregates”).The materials surveyed are classified as aggregates of smallmolecular metal complexes,which include monocomponent assemblies of Pt(II)complexes and other complexes and binary aggregates of metal complexes,and CPL-active metal-ligand coordination helicates,polymers,and frameworks.The efforts in improving the dissymmetry luminescence factors and quantum yields of these materials and the use of the aggregation strategy in enhancing the performance of isolated molecules are discussed.The recent applications of chiral metal complexes in circularly polarized organic light-emitting diodes(OLEDs)based on solution-or evaporation-processed procedures are surveyed.In addition,the uses of lanthanide complexes in CPL-contrast imaging and as CPL probes are highlighted.The common discussion on the mechanism of aggregation-enhanced CPLs and a perspective on future works of CPL-active coordination aggregates are finally given.展开更多
基金supported by the National Key Research and Development Program of China(2017YFA0700500)the National Natural Science Foundation of China(No.21635004,No.21627806)the Excellent Research Program of Nanjing University(No.ZYJH004)。
基金National Natural Science Foundation of China(No.81173171,81573864,81373533).
文摘Objective:To explore the characteristics of ZHANG Zhongjing's medication for constipation by analyzing the prescriptions of treatise on Shanghan Lun and Jingui Yaolue.Methods:the formulations that met the inclusion criteria were selected to establish a database,and the regularity of ZHANG Zhongjing's medication for constipation was analyzed by the methods of frequency,association rules and clustering.Results:In this study,11 prescriptions and 24 medicines were included.High-frequency use of drugs rhubarb,licorice,CortexMagnoliae Officinalis,fructus aurantii immaturus,mirabilis,ginger,jujube,white atractylodes rhizome,cassia twig,Chinese herbaceous peony.A total of 17 association rules(11 rules for 2 drugs and 6 rules for 3 drugs)were obtained by mining,including"Rhubarb+Mirabilite","fructus aurantii immaturus+Cortex Magnoliae Officinalis","Rhubarb+Cortex Magnoliae Officinalis","Rhubarb+Cortex Magnoliae Officinalis+fructus aurantii immaturus",and so on,and 7 groups of drug pair association group and 2 groups of multi-flavor drug association group were obtained.Network link analysis shows that there are 7 groups of strong link compatibility.Medium link compatibility 46 groups.Cluster analysis obtained 14 groups,including 8 single-taste drug groups,3 drug-pair polymerization groups and 3 multi-taste drug polymerization groups.Conclusions:ZHANG Zhongjing is not only good at using purgative medicine in treating constipation treating constipation,but also pays attention to invigorating qi and activating blood circulation,resolving the surface and regulating dampness,soothing the liver and regulating qi.
基金financial support from National Natural Science Foundation of China (No.81603072)。
文摘Pomalidomide is an immunomodulatory agent (IMiD) that has been approved by the US Food and Drug Administration (FDA) for clinical treatment of patients with multiple myeloma.In this work,we developed a sensitive and validated LC-MS/MS method for high-throughput determination of pomalidomide over the range of 1.006-100.6 ng/mL(R^(2)=0.9991) in human plasma and pharmacokinetic studies.A liquid-liquid extraction method using ethyl acetate was applied to extract pomalidomide and afatinib (as an internal standard,IS) from human plasma.Chromatographic separation was performed on a Hedera ODS column (150 mm×2.1 mm,5μm) with security guard C18 column (4 mm×2.0 mm) at 40℃.Methanol and 10 mmol/L aqueous solution of ammonium acetate containing 0.1%formic acid were used as a gradient elution mobile phase,and the flow rate was 0.4 mL/min.A triple quadruple tandem mass spectrometer using multiplex reaction monitoring mode (MRM) with electrospray ionization (ESI) positive ionization was employed.The precursor to product ion transitions for the quantitative analysis of pomalidomide and the IS were m/z 274.2→163.1 and m/z 486.1→371.1,respectively.This established method has been validated according to regulatory guideline,and the results were all within the acceptance criteria.The validated LC-MS/MS method was successfully applied to analyze samples obtained from clinical pharmacokinetics study after oral administration of pomalidomide (4 mg) capsules in human.
基金supported by the Ministry of Science and Technology of China (2022YFA1204401)the National Natural Science Foundation of China (21925112, 22090021)the BMS Junior Fellow of Beijing National Labortory for Molecular Sciences (BNLMS)。
文摘Materials with efficient circularly polarized phosphorescences(CPPs) are of potential use in advanced data encryption and anticounterfeiting, bioimaging, optoelectronic devices and so forth. Herein, a simple method is presented for the preparations of CPP-active micro/nanocrystals with large luminescence dissymmetry factors(glum), high phosphorescence quantum efficiencies(Φ_(P)) and tunable emission colors. Diastereomeric Ir^(Ⅲ) and Ru^(Ⅱ) complexes with chiral(±)-camphorsulfonate counter-anions are readily synthesized and assembled into crystalline microrods, microplates or nanofibers with ordered morphologies. The chirality information of chiral counter-anions is efficiently transferred to the metal components to afford CPPs with cyan, green,yellow, or red emission colors and Φ_(P)in the range of 5%–85%. The number of chiral anions is found to play a role in influencing the CPP magnitudes of these crystals. The dicationic Ru^(Ⅱ) and tricationic Ir^(Ⅲ) complexes show glumvalues in the 10^(-2)order, which are much larger with respect to those of monocationic Ir^(Ⅲ) complexes. Single crystal X-ray analysis is performed to obtain information on the chirality transfer of these materials. In addition, circularly polarized photonic signal waveguiding is demonstrated using the microcrystals of an Ir^(Ⅲ)complex. This work demonstrates an appealing strategy of constructing chiral micro/nano-architectures for potential applications in chiral nanophotonics.
基金the National Natural Science Foundation of China(Nos.22074061,21775066,21974058).
文摘Water behavior in nanoconfined hydrophobic environment is different from that in the bulk,which greatly influences mass transport.Hydrophobicity switching of nanopores showing great potential for controlled water or ion transport has been realized through several methods,especially the voltage-triggered wetting/dewetting inspired by biological ion channels.However,in the hydrophobic silanized nanopores,the finite ionic current is still observed and the ion transport mechanism is not yet clear.Here,we explore the ion transport behavior in the hydrophobic silanized anodic aluminum oxide(AAO).Ion transport through this hydrophobic membrane is confirmed,although no aqueous pathway was observed.Results show that ions transport through the cross-linked silane layer on the inner surface.It is revealed that metal ions,not just the protons or hydroxide ions,are involved in the ion transport driven by external electric field.This study provides a new insight into the ion transport in nanoconfined hydrophobic environment which is helpful to understand the biological processes and design new nanofluidic devices.
基金supported by the National Natural Science Foundation of China(nos.21635004,21775066,and 21974058).
文摘Harvesting the low-grade(<100°C)solar thermal energy with ionic heat-to-electricity conversion shows great promise but low efficiencies due to the challenges encountered in regulating ionic thermophoretic mobilities.Here,we used nanochannels to regulate thermal-driven ion transport properties and described a solar thermoelectric nanofluidic device(STEND).
基金National Natural Science Foundation of China,Grant/Award Numbers:21925112,22090021,21872154,21601194Beijing Natural Science Foundation,Grant/Award Number:2191003。
文摘The development and applications of materials with efficient circularly polarized luminescence(CPL)have become an interdisciplinary frontier research topic.We summarize herein the recent advance in the development and applications of CPLactive aggregates based on metal-ligand coordination materials(termed as“coordination aggregates”).The materials surveyed are classified as aggregates of smallmolecular metal complexes,which include monocomponent assemblies of Pt(II)complexes and other complexes and binary aggregates of metal complexes,and CPL-active metal-ligand coordination helicates,polymers,and frameworks.The efforts in improving the dissymmetry luminescence factors and quantum yields of these materials and the use of the aggregation strategy in enhancing the performance of isolated molecules are discussed.The recent applications of chiral metal complexes in circularly polarized organic light-emitting diodes(OLEDs)based on solution-or evaporation-processed procedures are surveyed.In addition,the uses of lanthanide complexes in CPL-contrast imaging and as CPL probes are highlighted.The common discussion on the mechanism of aggregation-enhanced CPLs and a perspective on future works of CPL-active coordination aggregates are finally given.