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胡椒碱对槟榔碱促进家兔离体小肠平滑肌运动的影响 被引量:2
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作者 陈钟权 符春茹 +3 位作者 符凤亲 陈颖 符昌文 高凌峰 《世界华人消化杂志》 CAS 2019年第1期20-28,共9页
目的观察胡椒碱对槟榔碱促进家兔离体小肠平滑肌运动的影响及其作用机制.方法采用离体平滑肌恒温灌流的方法,取家兔离体小肠,通过BL-420生物机能实验系统测定其张力的变化,观察不同浓度(0.06 g/L、0.6 g/L、6 g/L)胡椒碱溶液对正常状态... 目的观察胡椒碱对槟榔碱促进家兔离体小肠平滑肌运动的影响及其作用机制.方法采用离体平滑肌恒温灌流的方法,取家兔离体小肠,通过BL-420生物机能实验系统测定其张力的变化,观察不同浓度(0.06 g/L、0.6 g/L、6 g/L)胡椒碱溶液对正常状态下家兔离体小肠平滑肌自发性收缩的影响;先观察胡椒碱对家兔离体小肠平滑肌自发性收缩的影响,随后观察加入槟榔碱后对家兔离体小肠平滑肌自发性收缩的影响;为研究胡椒碱抑制家兔离体小肠平滑肌收缩的作用机制,应用IP3受体(inositol 1, 4, 5-trisphosphate, IP3)阻断剂肝素(Heparin,HP)、肌浆网ryanodine受体阻断剂钌红(ruthenium red,RR)和一氧化氮合酶抑制剂左旋硝基精氨酸甲酯(N'-nitro-L-arginine-methylesterhydrochloride,L-NAME),共同阐明胡椒碱对家兔离体小肠平滑肌作用的机制.结果胡椒碱抑制家兔离体小肠平滑肌自发性收缩,药物浓度在6 g/L时可显著抑制家兔离体小肠平滑肌收缩的振幅(P<0.01);在此基础上加入0.006 g/L槟榔碱溶液促进家兔离体小肠平滑肌收缩的振幅(P<0.05)且升高小肠收缩幅度小于单个槟榔碱促进家兔离体小肠平滑肌的收缩振幅(P<0.05); IP3受体HP能增强胡椒碱舒张家兔离体小肠平滑肌收缩的作用(P<0.05),而肌浆网ryanodine受体阻断剂钌红对胡椒碱舒张家兔小肠平滑肌的作用无明显影响(P>0.05); L-NAME能够部分阻断胡椒碱舒张家兔离体小肠平滑肌收缩的作用(P<0.05).结论胡椒碱可显著抑制家兔离体小肠平滑肌收缩的振幅;抑制单个槟榔碱促进家兔离体小肠平滑肌的收缩振幅;其机制可能与增加一氧化氮浓度,抑制IP3受体介导的内钙释放有关,但对肌浆网ryanodine受体途径引起的内钙释放无关. 展开更多
关键词 胡椒碱 槟榔碱 家兔小肠平滑肌 钙离子 一氧化氮
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Mobile Detecting Robot Controlled by Smartphone Based on iOS 被引量:1
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作者 Hou-Tsan Lee Hsiang-Lin Tsai +1 位作者 zhong-quan chen Yu-Ting Jiang 《Engineering(科研)》 2014年第12期750-757,共8页
The proposed scheme is composed of a smartphone, a vehicle equipped with Wi-Fi module and an IPCam working as a detecting robot to explore the unknown environment. Besides, another vehicle equipped with Wi-Fi module i... The proposed scheme is composed of a smartphone, a vehicle equipped with Wi-Fi module and an IPCam working as a detecting robot to explore the unknown environment. Besides, another vehicle equipped with Wi-Fi module is also developed as a trunk robot to extend the detecting range. On the other hand, these vehicles are designed to be driven by the smartphone based on iOS (an iPod Touch in the experiments) via Wi-Fi module along with some proper designs of control circuit mounted on the vehicles. By the audio-visual feedback signals from IPCam, the real-time scenario from the detecting area not only can be shown on the screen of the smartphone but also provides the information of the detected environment in order to guide the robot. Two control approaches were provided in the proposed control scheme, the touch-panel control and the smartphone-status control, to drive the vehicles with the help of visual feedback on the screen of the smartphone. Moreover, the trajectories of the robots were also recorded for further applications. Some experimental results are given to validate the satisfactory performance of the proposed control scheme. 展开更多
关键词 MOBILE ROBOT SMARTPHONE CONTROLLED IOS WI-FI
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