Exosomes are small vesicles secreted by all cell types in the brain and play a role in cell-cell communication through the transfer of cargo or encapsulation.Exosomes in the brain have considerable impact on neuronal ...Exosomes are small vesicles secreted by all cell types in the brain and play a role in cell-cell communication through the transfer of cargo or encapsulation.Exosomes in the brain have considerable impact on neuronal development,activation,and regeneration.In addition,exosomes are reported to be involved in the onset and propagation of various neurodegenerative diseases.In this review,we discuss the content of exosomes derived from major cell types in the brain,and their function under physiological and pathological conditions.展开更多
基金This research was supported by the National Natural Science Foundation of China(31871082,91849101,81601221)The Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)+3 种基金Key Research Program of Frontier Sciences of CAS(QYZDB-SSW-SMC035)the Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2018CXFX005)the Fundamental Research Funds for the Central Universities,and China Postdoctoral Science Foundation(2019M662178)The Open Fund of State Key Laboratory of Tea Plant Biology and Utilization(SKLTOF20150101)。
文摘Exosomes are small vesicles secreted by all cell types in the brain and play a role in cell-cell communication through the transfer of cargo or encapsulation.Exosomes in the brain have considerable impact on neuronal development,activation,and regeneration.In addition,exosomes are reported to be involved in the onset and propagation of various neurodegenerative diseases.In this review,we discuss the content of exosomes derived from major cell types in the brain,and their function under physiological and pathological conditions.
