Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths globally.The increased mortality rate of ES...Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths globally.The increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality rate.Unfortunately,there is currently no specific and effective marker to predict and treat metastasis in ESCC.MicroRNAs(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in length.miRNAs are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of cancer.Here,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic factors.This review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.展开更多
CO_(2)-assisted oxidative dehydrogenation of propane(CO_(2)-ODHP)is an attractive strategy to offset the demand gap of propylene due to its potentiality of reducing CO_(2)emissions,especially under the demands of peak...CO_(2)-assisted oxidative dehydrogenation of propane(CO_(2)-ODHP)is an attractive strategy to offset the demand gap of propylene due to its potentiality of reducing CO_(2)emissions,especially under the demands of peaking CO_(2)emissions and carbon neutrality.The introduction of CO_(2)as a soft oxidant into the reaction not only averts the over-oxidation of products,but also maintains the high oxidation state of the redox-active sites.Furthermore,the presence of CO_(2)increases the conversion of propane by coupling the dehydrogenation of propane(DHP)with the reverse water gas reaction(RWGS)and inhibits the coking formation to prolong the lifetime of catalysts via the reverse Boudouard reaction.An effective catalyst should selectively activate the C–H bond but suppress the C–C cleavage.However,to prepare such a catalyst remains challenging.Chromium-based catalysts are always applied in industrial application of DHP;however,their toxic properties are harmful to the environment.In this aspect,exploring environment-friendly and sustainable catalytic systems with Cr-free is an important issue.In this review,we outline the development of the CO_(2)-ODHP especially in the last ten years,including the structural information,catalytic performances,and mechanisms of chromium-free metal-based catalyst systems,and the role of CO_(2)in the reaction.We also present perspectives for future progress in the CO_(2)-ODHP.展开更多
( E)-5,5'-Bis( 5-( benzo[ b ]thiophen- 2-yl )thiophen-2-yl )-1,1'-bis( 2-ethylhexyl )-[ 3,3'-bipyrrolylidene ]- 2,2'(1H, l'H)-dione (BTBPD) has been reported by Zhang and co-workers. To further unders...( E)-5,5'-Bis( 5-( benzo[ b ]thiophen- 2-yl )thiophen-2-yl )-1,1'-bis( 2-ethylhexyl )-[ 3,3'-bipyrrolylidene ]- 2,2'(1H, l'H)-dione (BTBPD) has been reported by Zhang and co-workers. To further understand the charge-transporting nature of BTBPD, the density-functional theory (DFF) and the Marcus charge transfer theory were performed. The character of the frontier molecular orbitals, reorganization energies and transfer integrals in different directions were considered in details. The results revealed that the BTBPD has high hole transport efficiency (μ = 0.29 cm2 V-1 s-1 ). The intermolecular π-π interaction and S...S interaction provide the holes transport channels.展开更多
In this study,we consider the global optimization problem in a hypercube.We use a class of series to construct a curve in a hypercube,which can fill the hypercube,and we present an integral function on the curve.Based...In this study,we consider the global optimization problem in a hypercube.We use a class of series to construct a curve in a hypercube,which can fill the hypercube,and we present an integral function on the curve.Based on the integral function,we propose an algorithm for solving the global optimization problem.Then,we perform a convergence analysis and numerical experiments to demonstrate the effectiveness of the proposed algorithm.展开更多
基金Supported by Foundation of Henan Educational Committee,No.22A310024and Natural Science Foundation for Young Teachers'Basic Research of Zhengzhou University,No.JC202035025。
文摘Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths globally.The increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality rate.Unfortunately,there is currently no specific and effective marker to predict and treat metastasis in ESCC.MicroRNAs(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in length.miRNAs are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of cancer.Here,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic factors.This review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.
基金financially supported by the National Natural Science Foundation of China (Nos. 21978160, 22078182 and 21908139)the Key Industrial Innovation Project of Shaanxi Provincial Science and Technology Department (No. 2019ZDLGY06-04)+1 种基金the Project Supported by Natural Science Basic Research Plan in Shaanxi Province of China (No. 2019JLM-16)the Key Project of Education Department of Shaanxi Province (No. 21JY005)
文摘CO_(2)-assisted oxidative dehydrogenation of propane(CO_(2)-ODHP)is an attractive strategy to offset the demand gap of propylene due to its potentiality of reducing CO_(2)emissions,especially under the demands of peaking CO_(2)emissions and carbon neutrality.The introduction of CO_(2)as a soft oxidant into the reaction not only averts the over-oxidation of products,but also maintains the high oxidation state of the redox-active sites.Furthermore,the presence of CO_(2)increases the conversion of propane by coupling the dehydrogenation of propane(DHP)with the reverse water gas reaction(RWGS)and inhibits the coking formation to prolong the lifetime of catalysts via the reverse Boudouard reaction.An effective catalyst should selectively activate the C–H bond but suppress the C–C cleavage.However,to prepare such a catalyst remains challenging.Chromium-based catalysts are always applied in industrial application of DHP;however,their toxic properties are harmful to the environment.In this aspect,exploring environment-friendly and sustainable catalytic systems with Cr-free is an important issue.In this review,we outline the development of the CO_(2)-ODHP especially in the last ten years,including the structural information,catalytic performances,and mechanisms of chromium-free metal-based catalyst systems,and the role of CO_(2)in the reaction.We also present perspectives for future progress in the CO_(2)-ODHP.
基金the fnancial support from the Ministry of Science and Technology of China(No.09C26212203285)the Project of Science and Technology of Jilin Province(No.201115094)
文摘( E)-5,5'-Bis( 5-( benzo[ b ]thiophen- 2-yl )thiophen-2-yl )-1,1'-bis( 2-ethylhexyl )-[ 3,3'-bipyrrolylidene ]- 2,2'(1H, l'H)-dione (BTBPD) has been reported by Zhang and co-workers. To further understand the charge-transporting nature of BTBPD, the density-functional theory (DFF) and the Marcus charge transfer theory were performed. The character of the frontier molecular orbitals, reorganization energies and transfer integrals in different directions were considered in details. The results revealed that the BTBPD has high hole transport efficiency (μ = 0.29 cm2 V-1 s-1 ). The intermolecular π-π interaction and S...S interaction provide the holes transport channels.
基金the National Natural Science Foundation of China(No.11771275).
文摘In this study,we consider the global optimization problem in a hypercube.We use a class of series to construct a curve in a hypercube,which can fill the hypercube,and we present an integral function on the curve.Based on the integral function,we propose an algorithm for solving the global optimization problem.Then,we perform a convergence analysis and numerical experiments to demonstrate the effectiveness of the proposed algorithm.