Objective： To evaluate the clinical effect of postconditioning on patients with ST-elevation myocardial infarction （STEMI） treated with primary percutaneous coronary intervention （PCI）. Methods： Randomized contr...Objective： To evaluate the clinical effect of postconditioning on patients with ST-elevation myocardial infarction （STEMI） treated with primary percutaneous coronary intervention （PCI）. Methods： Randomized controlled trials were identified by searching relevant databases published up to April 2nd, 2014. A meta-analysis of eligible studies was performed by Stata 12.0 and Review Manager 5.2 with a fixed-effect model. Results： Ten studies providing adverse cardiac events in a total of 1346 STEMI patients treated with primary PCI were identified. The occurrence of heart failure was significantly reduced in patients treated with postconditioning compared with usual care （risk ratio （RR） 0.533; 95% confidence intervals （CI） 0.368-0.770）, whereas non-fatal reinfarction slightly increased in the postconditioning group （RR 2.746; 95% CI 1.007-7.488）. No significant difference in total major adverse cardiac events （MACEs） was observed between the two groups （RR 0.876; 95% CI 0.671-1.144）. Conclusions： Postcondi- tioning in STEMI patients undergoing primary PCI significantly reduces the risk of heart failure, but fails to decrease the incidence of total MACEs and the risk of non-fatal reinfarction.展开更多
基金supported by the Science and Technology Research Program of Jinhua Municipality(No.2014-3-052),China
文摘Objective： To evaluate the clinical effect of postconditioning on patients with ST-elevation myocardial infarction （STEMI） treated with primary percutaneous coronary intervention （PCI）. Methods： Randomized controlled trials were identified by searching relevant databases published up to April 2nd, 2014. A meta-analysis of eligible studies was performed by Stata 12.0 and Review Manager 5.2 with a fixed-effect model. Results： Ten studies providing adverse cardiac events in a total of 1346 STEMI patients treated with primary PCI were identified. The occurrence of heart failure was significantly reduced in patients treated with postconditioning compared with usual care （risk ratio （RR） 0.533; 95% confidence intervals （CI） 0.368-0.770）, whereas non-fatal reinfarction slightly increased in the postconditioning group （RR 2.746; 95% CI 1.007-7.488）. No significant difference in total major adverse cardiac events （MACEs） was observed between the two groups （RR 0.876; 95% CI 0.671-1.144）. Conclusions： Postcondi- tioning in STEMI patients undergoing primary PCI significantly reduces the risk of heart failure, but fails to decrease the incidence of total MACEs and the risk of non-fatal reinfarction.
