The copolymerization of DL-LA and 3-BMG was carried out in bulk with stannous 2-ethythexanoate as the catalyst. A series of copolymers with pendant protected groups were obtained and characterized by H-1-NMR and GPC a...The copolymerization of DL-LA and 3-BMG was carried out in bulk with stannous 2-ethythexanoate as the catalyst. A series of copolymers with pendant protected groups were obtained and characterized by H-1-NMR and GPC analysis. The monomer reactivity ratios were evaluated by the Fineman-Ross method and the Kelen-Tudos method and found to be r(BMG)=1.96 and r(LA)=0.37, respectively.展开更多
A substituted glycolide, 3-benzyloxymethyl-1,4-dioxane-2,5-dione, was synthesized. It is a suitable precursor for the preparation of a new hydrophilic biodegradable poly(a-hydroxy acid). The polymerizations were carri...A substituted glycolide, 3-benzyloxymethyl-1,4-dioxane-2,5-dione, was synthesized. It is a suitable precursor for the preparation of a new hydrophilic biodegradable poly(a-hydroxy acid). The polymerizations were carried out in bulk in the presence of Sn(Oct)(2) at 120-140 degreesC. The resulting polymers were subjected to hydrogenolysis with a Pd/C catalyst in a mixed solvent to remove the protecting benzyl groups. A novel poly(a-hydroxy acid) with pendant hydroxy groups was obtained. The hydrophilicity of the resulting polymer was evaluated preliminarily.展开更多
Inorganic polyhedral oligomeric silsesquioxane （POSS） was used as the core for the synthesis of poly（t- lysine） peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite ...Inorganic polyhedral oligomeric silsesquioxane （POSS） was used as the core for the synthesis of poly（t- lysine） peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite dendrimer was characterized by MS, 1H NMR, FTIR, GPC and DLS.展开更多
基金This work was supported by the Major State Basic Research Program of China (Grant No. G1999064704).
文摘The copolymerization of DL-LA and 3-BMG was carried out in bulk with stannous 2-ethythexanoate as the catalyst. A series of copolymers with pendant protected groups were obtained and characterized by H-1-NMR and GPC analysis. The monomer reactivity ratios were evaluated by the Fineman-Ross method and the Kelen-Tudos method and found to be r(BMG)=1.96 and r(LA)=0.37, respectively.
基金This work was supported by the Major State Basic Research Program of China (No. G1999064704).
文摘A substituted glycolide, 3-benzyloxymethyl-1,4-dioxane-2,5-dione, was synthesized. It is a suitable precursor for the preparation of a new hydrophilic biodegradable poly(a-hydroxy acid). The polymerizations were carried out in bulk in the presence of Sn(Oct)(2) at 120-140 degreesC. The resulting polymers were subjected to hydrogenolysis with a Pd/C catalyst in a mixed solvent to remove the protecting benzyl groups. A novel poly(a-hydroxy acid) with pendant hydroxy groups was obtained. The hydrophilicity of the resulting polymer was evaluated preliminarily.
基金supported by the National Basic Research Program of China(National 973 program,No.2011CB606206)National Science Foundation of China(NSFC,Nos.31170921,51133004)+1 种基金the National Science Foundation for Excellent Young Scholars(No.51222304)Program for Changjiang Scholars and Innovative Research Team in University(No.IRT1163)
文摘Inorganic polyhedral oligomeric silsesquioxane （POSS） was used as the core for the synthesis of poly（t- lysine） peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite dendrimer was characterized by MS, 1H NMR, FTIR, GPC and DLS.
