1 Introduction Imagery of the Western United States typically evokes vast wheat fields,cowboys,and rolling mountain valleys.Few would associate the American West with Chinese medicine.This article describes a remote t...1 Introduction Imagery of the Western United States typically evokes vast wheat fields,cowboys,and rolling mountain valleys.Few would associate the American West with Chinese medicine.This article describes a remote town called John Day,which is located in a mountainous terrain in Oregon,and presents the remarkable story of the Kam Wah Chung Museum(Fig.1).展开更多
This article discusses the history of animal glue(gelatin)used in medical practice in China.In ancient times,gelatin was widely made from cowhide and has been found in excavations and wall paintings older than 2000 ye...This article discusses the history of animal glue(gelatin)used in medical practice in China.In ancient times,gelatin was widely made from cowhide and has been found in excavations and wall paintings older than 2000 years in Egypt,Greece,and China.However,it has been used medicinally almost exclusively in China and other East Asian countries influenced by Chinese medicine.Since 11th century,donkey-hide has gradually been replaced with cowhide in medicinal gelatin.Currently,donkey-hide gelatin is widely used medicinally in China.During the Edo period,medicinal gelatin was imported to Japan from China.Owing to the distaste for eating animal flesh in traditional Japanese culture,the production of gelatin and its medicinal use is not widespread in Japan.展开更多
1 Introduction In 2015,an on-site field investigation was conducted by the authors’research group to authenticate a batch of ancient Chinese medicinal decoction pieces that have been preserved in a rare collection at...1 Introduction In 2015,an on-site field investigation was conducted by the authors’research group to authenticate a batch of ancient Chinese medicinal decoction pieces that have been preserved in a rare collection at the Natural History Museum in London.These treasured artifacts comprise a portion of the Sloane Collection,and the nearly 100 Chinese medicinal specimens examined within provide an objective record of the real situation regarding Chinese medicinal materials in commercial circulation 300 years ago.展开更多
Objective: Qianliguang(Senecio scandens) is a common Chinese medicinal herb. Qianliguang-containing herbal proprietary products are registered as over-the-counter remedies in China and exported to Western countries. T...Objective: Qianliguang(Senecio scandens) is a common Chinese medicinal herb. Qianliguang-containing herbal proprietary products are registered as over-the-counter remedies in China and exported to Western countries. The presence of hepatotoxic pyrrolizidine alkaloids(PAs)has raised concerns about the safety of using Qianliguang and its products. The present study aims at investigation of different types of PAs present in Qianliguang collected from representative locations in China.Methods: In this study, a simple but specific UHPLC-QTOF-MS method for the determination of toxic PAs was developed, based on the characteristic fragment ions specific to different types of PAs. It was successfully applied for the identification and distinguishing of PAs present in Qianliguang and related Senecio species growing in different locations of China.Results: Significant diversity of the PA types and quantities were revealed among the samples tested. The estimated total amounts of toxic PAs in three of the samples exceed the toxic limits of PA intake restricted by WHO, demonstrating the timely and highly demand for regulating both types and quantities of PAs present in Qianliguang.Conclusions: This study provides the methodology for simultaneous identification and quantification of PAs present in herbs without requiring corresponding standards, which could be further used for more systematic investigations of the PA distribution in Qianliguang and other PA-containing herbs.展开更多
The aim of the study was to identify main metabolites of benzylisoquinoline alkaloids from Nelumbinis Plumula after biotransformation by Caco-2 cells.Caco-2 cells were seeded to a 6-well plate and cultured for a perio...The aim of the study was to identify main metabolites of benzylisoquinoline alkaloids from Nelumbinis Plumula after biotransformation by Caco-2 cells.Caco-2 cells were seeded to a 6-well plate and cultured for a period of time until 80%of each well was filled with cells.Then,cell medium was replaced and the norcoclaurine,liensinine,isoliensinine and neferine were respectively added to展开更多
文摘1 Introduction Imagery of the Western United States typically evokes vast wheat fields,cowboys,and rolling mountain valleys.Few would associate the American West with Chinese medicine.This article describes a remote town called John Day,which is located in a mountainous terrain in Oregon,and presents the remarkable story of the Kam Wah Chung Museum(Fig.1).
基金financed by a grant from the Zhejiang Gongshang University,the Zhejiang Province"Foreign Language and Literature"Top Disciplines(A Class)Construction High-level Project(No.2020YLZS16)。
文摘This article discusses the history of animal glue(gelatin)used in medical practice in China.In ancient times,gelatin was widely made from cowhide and has been found in excavations and wall paintings older than 2000 years in Egypt,Greece,and China.However,it has been used medicinally almost exclusively in China and other East Asian countries influenced by Chinese medicine.Since 11th century,donkey-hide has gradually been replaced with cowhide in medicinal gelatin.Currently,donkey-hide gelatin is widely used medicinally in China.During the Edo period,medicinal gelatin was imported to Japan from China.Owing to the distaste for eating animal flesh in traditional Japanese culture,the production of gelatin and its medicinal use is not widespread in Japan.
文摘1 Introduction In 2015,an on-site field investigation was conducted by the authors’research group to authenticate a batch of ancient Chinese medicinal decoction pieces that have been preserved in a rare collection at the Natural History Museum in London.These treasured artifacts comprise a portion of the Sloane Collection,and the nearly 100 Chinese medicinal specimens examined within provide an objective record of the real situation regarding Chinese medicinal materials in commercial circulation 300 years ago.
基金Research Grant Council of Hong Kong(GRF Grants no.471310 and 469712)CUHK Direct Grant(2041744)
文摘Objective: Qianliguang(Senecio scandens) is a common Chinese medicinal herb. Qianliguang-containing herbal proprietary products are registered as over-the-counter remedies in China and exported to Western countries. The presence of hepatotoxic pyrrolizidine alkaloids(PAs)has raised concerns about the safety of using Qianliguang and its products. The present study aims at investigation of different types of PAs present in Qianliguang collected from representative locations in China.Methods: In this study, a simple but specific UHPLC-QTOF-MS method for the determination of toxic PAs was developed, based on the characteristic fragment ions specific to different types of PAs. It was successfully applied for the identification and distinguishing of PAs present in Qianliguang and related Senecio species growing in different locations of China.Results: Significant diversity of the PA types and quantities were revealed among the samples tested. The estimated total amounts of toxic PAs in three of the samples exceed the toxic limits of PA intake restricted by WHO, demonstrating the timely and highly demand for regulating both types and quantities of PAs present in Qianliguang.Conclusions: This study provides the methodology for simultaneous identification and quantification of PAs present in herbs without requiring corresponding standards, which could be further used for more systematic investigations of the PA distribution in Qianliguang and other PA-containing herbs.
文摘The aim of the study was to identify main metabolites of benzylisoquinoline alkaloids from Nelumbinis Plumula after biotransformation by Caco-2 cells.Caco-2 cells were seeded to a 6-well plate and cultured for a period of time until 80%of each well was filled with cells.Then,cell medium was replaced and the norcoclaurine,liensinine,isoliensinine and neferine were respectively added to
