Transcription co-repressors are negative regulators of gene expression. Since they do not possess a DNA-binding motif, their ability to repress gene expression depends on their association with other DNA-binding trans...Transcription co-repressors are negative regulators of gene expression. Since they do not possess a DNA-binding motif, their ability to repress gene expression depends on their association with other DNA-binding transcription factors. One well characterized transcription co-repressor is the yeast Tupl. Although unable to bind DNA by itself, the Tupl co-repressor is recruited by different DNA-binding transcription factors to repress pathway-spocific gene expression. Recent isolations of two Arabidopsis genes, LEUNIG (LUG) and SEUSS ( SEU), suggest that similar types of co-re-pressors are involved in the transcription repression of floral homeotic genes during flower develop-ment. This review will summarize these findings, speculate on mechanisms, and discuss future di-rections.展开更多
文摘Transcription co-repressors are negative regulators of gene expression. Since they do not possess a DNA-binding motif, their ability to repress gene expression depends on their association with other DNA-binding transcription factors. One well characterized transcription co-repressor is the yeast Tupl. Although unable to bind DNA by itself, the Tupl co-repressor is recruited by different DNA-binding transcription factors to repress pathway-spocific gene expression. Recent isolations of two Arabidopsis genes, LEUNIG (LUG) and SEUSS ( SEU), suggest that similar types of co-re-pressors are involved in the transcription repression of floral homeotic genes during flower develop-ment. This review will summarize these findings, speculate on mechanisms, and discuss future di-rections.
