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E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells 被引量:6
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作者 Xiaoqi Song Shuo Liu +3 位作者 Wendie Wang zhongfei ma Xuetao Cao Minghong Jiang 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2020年第8期865-874,共10页
Upon recognition of dsRNA,toll-like receptor 3(TLR3)recruits the adaptor protein TRIF to activate IRF3 and NF-κB signaling,initiating innate immune responses.The ubiquitination of TLR3 downstream signaling molecules ... Upon recognition of dsRNA,toll-like receptor 3(TLR3)recruits the adaptor protein TRIF to activate IRF3 and NF-κB signaling,initiating innate immune responses.The ubiquitination of TLR3 downstream signaling molecules and their roles in the innate response have been discovered;however,whether TLR3 itself is ubiquitinated and then functionally involved remains to be elucidated.By immunoprecipitating TLR3-binding proteins in macrophages,we identified ring finger protein 170(RNF170)as a TLR3-binding E3 ligase.RNF170 mediated the K48-linked polyubiquitination of K766 in the TIR domain of TLR3 and promoted the degradation of TLR3 through the proteasome pathway.The genetic ablation of RNF170 selectively augmented TLR3-triggered innate immune responses both in vitro and in vivo.Our results reveal a novel role for RNF170 in selectively inhibiting TLR3-triggered innate immune responses by promoting TLR3 degradation. 展开更多
关键词 TLR3 RNF170 UBIQUITINATION DEGRADATION Innate immunity
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Construction of vesicle CdSe nano-semiconductors photocatalysts with improved photocatalytic activity:Enhanced photo induced carriers separation efficiency and mechanism insight 被引量:3
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作者 Jiangsu Wen Changchang ma +6 位作者 Pengwei Huo Xinlin Liu maobin Wei Yang Liu Xin Yao zhongfei ma Yongsheng Yan 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2017年第10期98-107,共10页
Visible-light-driven photocatalysis as a green technology has attracted a lot of attention due to its potential applications in environmental remediation. Vesicle Cd Se nano-semiconductor photocatalyst are successfull... Visible-light-driven photocatalysis as a green technology has attracted a lot of attention due to its potential applications in environmental remediation. Vesicle Cd Se nano-semiconductor photocatalyst are successfully prepared by a gas template method and characterized by a variety of methods. The vesicle Cd Se nano-semiconductors display enhanced photocatalytic performance for the degradation of tetracycline hydrochloride, the photodegradation rate of78.824% was achieved by vesicle Cd Se, which exhibited an increase of 31.779% compared to granular Cd Se. Such an exceptional photocatalytic capability can be attributed to the unique structure of the vesicle Cd Se nano-semiconductor with enhanced light absorption ability and excellent carrier transport capability. Meanwhile, the large surface area of the vesicle Cd Se nano-semiconductor can increase the contact probability between catalyst and target and provide more surface-active centers. The photocatalytic mechanisms are analyzed by active species quenching. It indicates that h+and UO2^-are the main active species which play a major role in catalyzing environmental toxic pollutants. Simultaneously, the vesicle Cd Se nano-semiconductor had high efficiency and stability. 展开更多
关键词 Nano-semiconductor Vesicle CdSe Gas template Photocatalyst
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