Hypertension(HT)is the most common public-health challenge andshows a high inci-dence around the world.Cardiovascular diseases are the leadingcause of mortality and morbidity among the elderly(age>65 years)in the U...Hypertension(HT)is the most common public-health challenge andshows a high inci-dence around the world.Cardiovascular diseases are the leadingcause of mortality and morbidity among the elderly(age>65 years)in the UnitedStates.Now,there is widespread acceptanceof the causal link between HT and acute myocardial infarction(MI).This is the first data-mining study to identify co-expressed differentially expressed genes(Co-DEGs)between HT and MI(rela-tive to nommal control)and to uncover potential biomarkers and therapeutic targets of HT-related MI.In thismanuscript,HT-specfcDEGs andMl-specific DEGs and dffretially expressed microRNAs(DE-miRNAs)were identifhed in Gene Expression Omnibus(GEO)datasets GSE24752,GSE60993,GSE62646,and GSE24548 after data consolidation and batch correction.Subse-quently,enichmentin Gene Ontology(GO)terms and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways as well as protein-protein interaction networks were identified,and single-gene gene set enrichment analysis was performed to determine the affected biological cate-gories and networks.Cross-matching of the results on cCo-DE-miRNAs and predicted miRNAs tar-geting the Co-DEGs wasconducted and discussed as well.We found thatMYC and HIST1H2BO may be associatedwith HT,whereas FCGR 1A,FYN,KLRD1,KLRB1,and FOLR3 may be implicated in MI.Moreover,Co-DEGs FOLR3 and NFE2 with predicted miRNAs and DE-miRNAs,especially miR-7 and miR-548,may be significantly associated and show huge potential as a new set of novel bio-markers and important molecular targets in the course of HT-related MI.展开更多
基金This work was supported by the Postgraduate Research&Practice Innovation Program of Jiangsu Province(grant number KYCX18_1462)Nanjing Health Youth Talent Training Project in in 13th Five-Year(grant number QRX17113)+1 种基金Nanjing Medical Science and technique Devel-opment Foundation(grant number QRX17057)the Natural Science Foundation of China(grant numbers 81700392 and 81601539).
文摘Hypertension(HT)is the most common public-health challenge andshows a high inci-dence around the world.Cardiovascular diseases are the leadingcause of mortality and morbidity among the elderly(age>65 years)in the UnitedStates.Now,there is widespread acceptanceof the causal link between HT and acute myocardial infarction(MI).This is the first data-mining study to identify co-expressed differentially expressed genes(Co-DEGs)between HT and MI(rela-tive to nommal control)and to uncover potential biomarkers and therapeutic targets of HT-related MI.In thismanuscript,HT-specfcDEGs andMl-specific DEGs and dffretially expressed microRNAs(DE-miRNAs)were identifhed in Gene Expression Omnibus(GEO)datasets GSE24752,GSE60993,GSE62646,and GSE24548 after data consolidation and batch correction.Subse-quently,enichmentin Gene Ontology(GO)terms and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways as well as protein-protein interaction networks were identified,and single-gene gene set enrichment analysis was performed to determine the affected biological cate-gories and networks.Cross-matching of the results on cCo-DE-miRNAs and predicted miRNAs tar-geting the Co-DEGs wasconducted and discussed as well.We found thatMYC and HIST1H2BO may be associatedwith HT,whereas FCGR 1A,FYN,KLRD1,KLRB1,and FOLR3 may be implicated in MI.Moreover,Co-DEGs FOLR3 and NFE2 with predicted miRNAs and DE-miRNAs,especially miR-7 and miR-548,may be significantly associated and show huge potential as a new set of novel bio-markers and important molecular targets in the course of HT-related MI.
