Acquired immune deficiency syndrome is still one of the most severe global infectious diseases that pose a significant threat to human health.With the successful application of antiretroviral therapy,productive replic...Acquired immune deficiency syndrome is still one of the most severe global infectious diseases that pose a significant threat to human health.With the successful application of antiretroviral therapy,productive replication of human immunodeficiency virus type 1(HIV-1)can be effectively blocked;however,antiretroviral therapy alone cannot cure the infection because of the presence of a stable and reactivatable viral latent reservoir.Thus,it is of great importance to have a better comprehension of themechanisms driving HIV-1 pathogenesis and long-term persistence in infected individuals,based on which to further discover novel targets for therapeutic applications to treat or even cure the infection.Various studies have revealed that cellularmetabolism is a critical factor impacting the fate and intracellular activities of immune cells.Emerging evidence implies that the alternations of cellular metabolism induced by HIV-1 infection play an important role in HIV-1 pathogenesis.Consequently,a promising approach of“metabolism as a therapeutic target”raised the possibility of using metabolic reprogramming as a treatment option for chronic HIV-1 infection.In this review,we summarize the latest studies about the interplay of the hosts'reprogramming of glucose metabolism and HIV-1 infection and introduce potential applications of searching for hallmarks and therapeutic targets of metabolic interventions for HIV-1 infection.展开更多
文摘Acquired immune deficiency syndrome is still one of the most severe global infectious diseases that pose a significant threat to human health.With the successful application of antiretroviral therapy,productive replication of human immunodeficiency virus type 1(HIV-1)can be effectively blocked;however,antiretroviral therapy alone cannot cure the infection because of the presence of a stable and reactivatable viral latent reservoir.Thus,it is of great importance to have a better comprehension of themechanisms driving HIV-1 pathogenesis and long-term persistence in infected individuals,based on which to further discover novel targets for therapeutic applications to treat or even cure the infection.Various studies have revealed that cellularmetabolism is a critical factor impacting the fate and intracellular activities of immune cells.Emerging evidence implies that the alternations of cellular metabolism induced by HIV-1 infection play an important role in HIV-1 pathogenesis.Consequently,a promising approach of“metabolism as a therapeutic target”raised the possibility of using metabolic reprogramming as a treatment option for chronic HIV-1 infection.In this review,we summarize the latest studies about the interplay of the hosts'reprogramming of glucose metabolism and HIV-1 infection and introduce potential applications of searching for hallmarks and therapeutic targets of metabolic interventions for HIV-1 infection.
