To the Editor:Malignant hyperthermia(MH)is a pharmacogenetic disorder of skeletal muscles that presents as an acute hypermetabolic state triggered by depolarizing muscle relaxants and volatile anesthetics in susceptib...To the Editor:Malignant hyperthermia(MH)is a pharmacogenetic disorder of skeletal muscles that presents as an acute hypermetabolic state triggered by depolarizing muscle relaxants and volatile anesthetics in susceptible individuals.[1]The reported incidence of MH reaction ranged from 1:250,000 to 1:10,000.[1]However,the exact incidence in the Asian population remains unknown.A recent report suggested that the incidence of MH in Japan was 1 to 2 per 100,000 anesthetics,[2]which was similar to that in Western countries.In China,there are only a few reported cases,which may be attributed to incomplete records,and the actual incidence might be higher.[3,4]In China,between January 1978 and March 2004,only 34 cases of MH were recorded.[5]Due to the lack of the effective drug dantrolene,the mortality rate at that time was 73.5%.[5]Here,we reported the onset and treatment of a patient with suspected MH.展开更多
基金Clinical Research Innovation Plan of Shanghai General Hospital(No.KD031-ly01)Clinical Research Innovation Plan of Shanghai General Hospital(No.CTCCR-2021C21)
文摘To the Editor:Malignant hyperthermia(MH)is a pharmacogenetic disorder of skeletal muscles that presents as an acute hypermetabolic state triggered by depolarizing muscle relaxants and volatile anesthetics in susceptible individuals.[1]The reported incidence of MH reaction ranged from 1:250,000 to 1:10,000.[1]However,the exact incidence in the Asian population remains unknown.A recent report suggested that the incidence of MH in Japan was 1 to 2 per 100,000 anesthetics,[2]which was similar to that in Western countries.In China,there are only a few reported cases,which may be attributed to incomplete records,and the actual incidence might be higher.[3,4]In China,between January 1978 and March 2004,only 34 cases of MH were recorded.[5]Due to the lack of the effective drug dantrolene,the mortality rate at that time was 73.5%.[5]Here,we reported the onset and treatment of a patient with suspected MH.
