Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases,which involve plenty of immune cells,pathogens and autoantibodies.Nanomedicine has a gr...Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases,which involve plenty of immune cells,pathogens and autoantibodies.Nanomedicine has a great potential in modulating immune system.Particularly,biomimetic nanomodulators can be designed for prevention,diagnosis and therapy to achieve a better targeted immunotherapy.With the development of materials science and bioengineering,a wide range of membranecoated nanomodulators are available.Herein,we summarize recent advancements of bioinspired membrane-coated nanoplatform for systemic protection against immune-related diseases including autoimmune and infectious diseases.We also rethink the challenges or limitations in the progress of the therapeutic nanoplatform,and discuss the further application of the nanomodulators in the view of translational medicine for combating immune-related diseases.展开更多
基金supported by the Major State Basic Research Development Program of China(2017YFA0205201)the National Natural Science Foundation of China(81925019,81901876,81801817,81603015 and U1705281)+3 种基金the Fundamental Research Funds for the Central Universities(20720190138,20720190088 and 20720200019,China)Medical and Health Key project of Xiamen(3502Z20191106 and 2020Y4003,China)the Program for New Century Excellent Talents in University,China(NCET13-0502)China Postdoctoral Science Foundation Funded Project(K6419001,China)。
文摘Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases,which involve plenty of immune cells,pathogens and autoantibodies.Nanomedicine has a great potential in modulating immune system.Particularly,biomimetic nanomodulators can be designed for prevention,diagnosis and therapy to achieve a better targeted immunotherapy.With the development of materials science and bioengineering,a wide range of membranecoated nanomodulators are available.Herein,we summarize recent advancements of bioinspired membrane-coated nanoplatform for systemic protection against immune-related diseases including autoimmune and infectious diseases.We also rethink the challenges or limitations in the progress of the therapeutic nanoplatform,and discuss the further application of the nanomodulators in the view of translational medicine for combating immune-related diseases.
