Ageing is one of the greatest risk factors for neurodegenerative diseases.How the complex biological changes in ageing increase the brain’s susceptibility to neurodegeneration remains incompletely understood.Research...Ageing is one of the greatest risk factors for neurodegenerative diseases.How the complex biological changes in ageing increase the brain’s susceptibility to neurodegeneration remains incompletely understood.Research into neurodegenerative disorders has shifted from a neuron-centric approach,to the contributing roles of age-related neurovascular and glial cell dysfunction.展开更多
Aiming at the robustness issue in high-speed trains(HSTs)operation control,this article proposes a model-free adaptive control(MFAC)scheme to suppress disturbance.Firstly,the dynamic linearization data model of train ...Aiming at the robustness issue in high-speed trains(HSTs)operation control,this article proposes a model-free adaptive control(MFAC)scheme to suppress disturbance.Firstly,the dynamic linearization data model of train system under the action of measurement disturbance is given,and the Kalman filter(KF)based on this model is derived under the minimum variance estimation criterion.Then,according to the KF,an anti-interference MFAC scheme is designed.This scheme only needs the input and output data of the controlled system to realize the MFAC of the train under strong disturbance.Finally,the simulation experiment of CRH380A HSTs is carried out and compared with the traditional MFAC and the MFAC with attenuation factor.The proposed control algorithm can effectively suppress the measurement disturbance,and obtain smaller tracking error and larger signal to noise ratio with better applicability.展开更多
An altered proteome in lymph nodes often suggests abnormal signaling pathways that may be associated with diverse lymphatic disorders.Current clinical biomarkers for histological classification of lymphomas have encou...An altered proteome in lymph nodes often suggests abnormal signaling pathways that may be associated with diverse lymphatic disorders.Current clinical biomarkers for histological classification of lymphomas have encountered many discrepancies,particularly for borderline cases.Therefore,we launched a comprehensive proteomic study aimed to establish a proteomic landscape of patients with various lymphatic disorders and identify proteomic variations associated with different disease subgroups.In this study,109 fresh-frozen lymph node tissues from patients with various lymphatic disorders(with a focus on Non-Hodgkin’s Lymphoma)were analyzed by data-independent acquisition mass spectrometry.A quantitative proteomic landscape was comprehensively characterized,leading to the identification of featured protein profiles for each subgroup.Potential correlations between clinical outcomes and expression profiles of signature proteins were also probed.Two representative signature proteins,phospholipid-binding proteins Annexin A6(ANXA6)and Phospholipase C Gamma 2(PLCG2),were successfully validated via immunohistochemistry.We also evaluated the capability of acquired proteomic signatures to segregate multiple lymphatic abnormalities and identified several core signature proteins,such as Sialic Acid Binding Ig Like Lectin 1(SIGLEC1)and GTPase of immunity-associated protein 5(GIMAP5).In summary,the established lympho-specific data resource provides a comprehensive map of protein expression in lymph nodes during multiple disease states,thus extending the existing human tissue proteome atlas.Our findings will be of great value in exploring protein expression and regulation underlying lymphatic malignancies,while also providing novel protein candidates to classify various lymphomas for more precise medical practice.展开更多
基金The present work was supported by a Croucher Innovation Award from the Croucher Foundation(to HK)a Faculty Innovation Award(FIA2017/B/01)from the Faculty of Medicine,the Chinese University of Hong Kong(CUHK)(to HK)+1 种基金the Gerald Choa Neuroscience Centre,the Margaret K.L.Cheung Research Centre for Parkinsonism Management,Faculty of Medicine,CUHK(to VCTM and HK)the Collaborative Research Fund(C6027-19GF)and the Area of Excellence Scheme(AoE/M-604/16)of the University Grants Committee of Hong Kong(to HK).
文摘Ageing is one of the greatest risk factors for neurodegenerative diseases.How the complex biological changes in ageing increase the brain’s susceptibility to neurodegeneration remains incompletely understood.Research into neurodegenerative disorders has shifted from a neuron-centric approach,to the contributing roles of age-related neurovascular and glial cell dysfunction.
基金The authors thank the anonymous reviewers for their valuable suggestions.This work is supported by funds National Natural Science Foundation of China(Grants No.52162048,61991404 and 62003138)National Key Research and Development Program of China(Grant No.2020YFB1713703)Jiangxi Graduate Innovation Fund Project(Grant No.YC2021-S446).
文摘Aiming at the robustness issue in high-speed trains(HSTs)operation control,this article proposes a model-free adaptive control(MFAC)scheme to suppress disturbance.Firstly,the dynamic linearization data model of train system under the action of measurement disturbance is given,and the Kalman filter(KF)based on this model is derived under the minimum variance estimation criterion.Then,according to the KF,an anti-interference MFAC scheme is designed.This scheme only needs the input and output data of the controlled system to realize the MFAC of the train under strong disturbance.Finally,the simulation experiment of CRH380A HSTs is carried out and compared with the traditional MFAC and the MFAC with attenuation factor.The proposed control algorithm can effectively suppress the measurement disturbance,and obtain smaller tracking error and larger signal to noise ratio with better applicability.
基金This study was approved by Research Ethics Committee of the First Affiliated Hospital,College of Medicine,Zhejiang University(2018-920).
文摘An altered proteome in lymph nodes often suggests abnormal signaling pathways that may be associated with diverse lymphatic disorders.Current clinical biomarkers for histological classification of lymphomas have encountered many discrepancies,particularly for borderline cases.Therefore,we launched a comprehensive proteomic study aimed to establish a proteomic landscape of patients with various lymphatic disorders and identify proteomic variations associated with different disease subgroups.In this study,109 fresh-frozen lymph node tissues from patients with various lymphatic disorders(with a focus on Non-Hodgkin’s Lymphoma)were analyzed by data-independent acquisition mass spectrometry.A quantitative proteomic landscape was comprehensively characterized,leading to the identification of featured protein profiles for each subgroup.Potential correlations between clinical outcomes and expression profiles of signature proteins were also probed.Two representative signature proteins,phospholipid-binding proteins Annexin A6(ANXA6)and Phospholipase C Gamma 2(PLCG2),were successfully validated via immunohistochemistry.We also evaluated the capability of acquired proteomic signatures to segregate multiple lymphatic abnormalities and identified several core signature proteins,such as Sialic Acid Binding Ig Like Lectin 1(SIGLEC1)and GTPase of immunity-associated protein 5(GIMAP5).In summary,the established lympho-specific data resource provides a comprehensive map of protein expression in lymph nodes during multiple disease states,thus extending the existing human tissue proteome atlas.Our findings will be of great value in exploring protein expression and regulation underlying lymphatic malignancies,while also providing novel protein candidates to classify various lymphomas for more precise medical practice.