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Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery 被引量:1
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作者 Jie Li zhongshi wang +6 位作者 Han Han Zhonghua Xu Shasha Li Ying Zhu Yuejian Chen Liang Ge Yuan Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第4期1936-1940,共5页
Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for... Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for drug delivery. In this study, we developed a novel and injectable drug delivery platform for the antitumor drug doxorubicin(DOX) using a p H-responsive ionic-complementary octapeptide FOE.This octapeptide could self-assemble into stable hydrogel under neutral conditions, while disassemble under the tumor microenvironment. Especially, at p H 5.8, its micromorphology displayed a transition from nanofibers to nanospheres with the change of secondary structure, which enhanced cellular uptake of DOX. In addition, FOE hydrogel serves as a smart drug reservoir by localized injection to achieve sustained drug release and improve antitumor efficacy. This octapeptide opens up new avenues for promoting the clinical translation of anticancer drugs on account of excellent injectable properties and economic benefits of simple and short sequence. 展开更多
关键词 Peptide hydrogel pH Sensitivity ANTITUMOR Drug delivery Targeted therapy
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