Dear Editor,Motor control as a function of the basal ganglia circuit is crucial for every aspect of life and movement disorders,such as Parkinson’s disease(PD).In PD,the progressive denervation of dopamine in the dor...Dear Editor,Motor control as a function of the basal ganglia circuit is crucial for every aspect of life and movement disorders,such as Parkinson’s disease(PD).In PD,the progressive denervation of dopamine in the dorsal striatum leads to inhibition of the direct pathway and facilitation of the indirect pathway and results in activation of the subthalamic nucleus(STN)and globus pallidus internus(GPi),two important nuclei in the motor loop of basal ganglia.展开更多
基金This work was supported by a grant from the National Natural Science Foundation of China (81830034).
文摘Dear Editor,Motor control as a function of the basal ganglia circuit is crucial for every aspect of life and movement disorders,such as Parkinson’s disease(PD).In PD,the progressive denervation of dopamine in the dorsal striatum leads to inhibition of the direct pathway and facilitation of the indirect pathway and results in activation of the subthalamic nucleus(STN)and globus pallidus internus(GPi),two important nuclei in the motor loop of basal ganglia.
