Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure,lipid profile and blood glucose level

To study the relationship of the polymorphism of endothelial nitric oxide synthase(eNOS)gene and blood pressure,lipid profiles and blood glucose level.By using PCR-RFLP,the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertension and 196 matched healthy individuals with normal blood pressure.Taking into account eNOS Glu298Asp poly-morphisms,the relationship of blood pressure with trigly-cerides(TG),total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL)and blood glucose level was analyzed.The distribution of eNOS Glu298Asp polymorphism had no significant differ-ence between different blood pressure groups and gender groups,but there was a significant difference between dif-ferent age groups,diastolic blood pressure groups or BMI groups(P<0.05).Asp/Asp genotype significantly increased the risk of hypertension in individuals with serum TC above 5.4 mmol/L(P=0.03,OR=52.65).eNOS Glu298Asp polymorphism and serum lipid could synergis-tically modulate the blood pressure.eNOS Asp/Asp geno-type could significantly increase the risk of hypertension in individuals with serum TC over 5.4 mmol/L.eNOS Glu298Asp in combination with serum TC could be used to predict the risk of hypertension.