Osteoporosis(OP)is a metabolic bone disease characterized by decreased bone mass,reduced bone density,and destruction of bone microstructures,which resulting in an increased brittleness and susceptibility to fractures...Osteoporosis(OP)is a metabolic bone disease characterized by decreased bone mass,reduced bone density,and destruction of bone microstructures,which resulting in an increased brittleness and susceptibility to fractures.The incidence of osteoporosis is associated with aging and some genetical and physiology abnormalities.With the accelerated growth of aged population in China,a large group of population has reduced bone density.The mid-aged and senior people are highly susceptible to osteoporosis.While some young people who have irregular dietary schedule and unhealthy life style might cause increased rate of osteoporosis.Signal transducers and activators of transcription 3(STAT3)is a transcription factor ubiquitously expressed in somatic and stem cells such as tumor cells,mesenchymal stem cells,osteoblasts,osteoclasts and osteocytes.STAT3 is involved in the regulation of cell proliferation differentiation,apoptosis,and other physiological functions.The results of relevant animal experiments and clinical trials showed that abnormal expression of STAT3 would affect normal bone development.展开更多
文摘Osteoporosis(OP)is a metabolic bone disease characterized by decreased bone mass,reduced bone density,and destruction of bone microstructures,which resulting in an increased brittleness and susceptibility to fractures.The incidence of osteoporosis is associated with aging and some genetical and physiology abnormalities.With the accelerated growth of aged population in China,a large group of population has reduced bone density.The mid-aged and senior people are highly susceptible to osteoporosis.While some young people who have irregular dietary schedule and unhealthy life style might cause increased rate of osteoporosis.Signal transducers and activators of transcription 3(STAT3)is a transcription factor ubiquitously expressed in somatic and stem cells such as tumor cells,mesenchymal stem cells,osteoblasts,osteoclasts and osteocytes.STAT3 is involved in the regulation of cell proliferation differentiation,apoptosis,and other physiological functions.The results of relevant animal experiments and clinical trials showed that abnormal expression of STAT3 would affect normal bone development.
