Compared with surgery alone, post-operative adjuvant chemotherapy (ACT) for local colorectal cancer (CRC) can significantly improve survival.[1,2] The benefit of adjuvant fluorouracil (5-FU)-based chemotherapy in stag...Compared with surgery alone, post-operative adjuvant chemotherapy (ACT) for local colorectal cancer (CRC) can significantly improve survival.[1,2] The benefit of adjuvant fluorouracil (5-FU)-based chemotherapy in stage III CRC was established in the National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocol C-01 trial[3] and consolidated in subsequent studies.展开更多
The presence of large segmental defects of the diaphyseal bone is challenging for orthopedic surgeons. Free vascularized fibular grafting （FVFG） is considered to be a reliable reconstructive procedure. Stress fractu...The presence of large segmental defects of the diaphyseal bone is challenging for orthopedic surgeons. Free vascularized fibular grafting （FVFG） is considered to be a reliable reconstructive procedure. Stress fractures are a common complication following this surgery, and hypertrophy is the main physiological change of the grafted fibula. The exact mechanism of hypertrophy is not completely known. To the best of our knowledge, no studies have examined the possible relationship between stress fractures and hypertrophy. We herein report three cases of patients underwent FVFG. Two of them developed stress fractures and significant hypertrophy, while the remaining patient developed neither stress fractures nor significant hypertrophy. This phenomenon indicates that a relationship may exist between stress frac~ tures and hypertrophy of the grafted fibula, specifically, that the presence of a stress fracture may initiate the process of hypertrophy,展开更多
基金grants from the National Natural Science Foundation of China(No.81872013)the National Key Research and Development Program(No.2017YFC0108300)+1 种基金the Science and Technology Planning Project of Guangdong Province(No.2017B020226005)the National Clinical Key Specialty Construction Project(No.[2012]121).
文摘Compared with surgery alone, post-operative adjuvant chemotherapy (ACT) for local colorectal cancer (CRC) can significantly improve survival.[1,2] The benefit of adjuvant fluorouracil (5-FU)-based chemotherapy in stage III CRC was established in the National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocol C-01 trial[3] and consolidated in subsequent studies.
文摘The presence of large segmental defects of the diaphyseal bone is challenging for orthopedic surgeons. Free vascularized fibular grafting （FVFG） is considered to be a reliable reconstructive procedure. Stress fractures are a common complication following this surgery, and hypertrophy is the main physiological change of the grafted fibula. The exact mechanism of hypertrophy is not completely known. To the best of our knowledge, no studies have examined the possible relationship between stress fractures and hypertrophy. We herein report three cases of patients underwent FVFG. Two of them developed stress fractures and significant hypertrophy, while the remaining patient developed neither stress fractures nor significant hypertrophy. This phenomenon indicates that a relationship may exist between stress frac~ tures and hypertrophy of the grafted fibula, specifically, that the presence of a stress fracture may initiate the process of hypertrophy,
