Radical-polar crossover(RPC) reaction bridges the gap between one-and two-electron reactivities,thus providing an ideal solution to overcome the limitations of both radical and polar chemistry.In this manifold,organic...Radical-polar crossover(RPC) reaction bridges the gap between one-and two-electron reactivities,thus providing an ideal solution to overcome the limitations of both radical and polar chemistry.In this manifold,organic electrochemistry provides a uniquely facile strategy to access a diverse array of radical intermediates,thus broadening the chemical space of the RPC concept.This review highlights the synthetic advances in the field of electrochemical RPC reactions since 2020,with an emphasis on the substrate scope,reaction limitation and mechanistic aspect.The related RPC reactions are categorized as netoxidative,net-reductive,or redox neutral transformations.展开更多
基金supported by the National Natural Science Foundation of China (22171015,22271009)the Beijing Natural Science Foundation (2222003)the Beijing Municipal Education Committee Project (KZ202110005003,KM202110005006)。
文摘Radical-polar crossover(RPC) reaction bridges the gap between one-and two-electron reactivities,thus providing an ideal solution to overcome the limitations of both radical and polar chemistry.In this manifold,organic electrochemistry provides a uniquely facile strategy to access a diverse array of radical intermediates,thus broadening the chemical space of the RPC concept.This review highlights the synthetic advances in the field of electrochemical RPC reactions since 2020,with an emphasis on the substrate scope,reaction limitation and mechanistic aspect.The related RPC reactions are categorized as netoxidative,net-reductive,or redox neutral transformations.
