目的比较盐酸纳布啡和舒芬太尼对小儿尺桡骨骨折闭合复位克氏针内固定术后的镇痛效果及不良反应,探讨盐酸纳布啡用于术后镇痛的安全性和有效性。方法选取湖南省儿童医院于2017年9月至2018年8月收治的60例尺桡骨骨折需行尺桡骨闭合复位...目的比较盐酸纳布啡和舒芬太尼对小儿尺桡骨骨折闭合复位克氏针内固定术后的镇痛效果及不良反应,探讨盐酸纳布啡用于术后镇痛的安全性和有效性。方法选取湖南省儿童医院于2017年9月至2018年8月收治的60例尺桡骨骨折需行尺桡骨闭合复位克氏针内固定的患儿为研究对象,依据术后镇痛药物的不同分为盐酸纳布啡组( n =30)和舒芬太尼组( n =30)。比较两组镇痛镇静效果及术后呼吸抑制、恶心呕吐、皮肤瘙痒等不良反应发生率。结果手术前两组患儿的FLACC评分分别为(1.56±0.32)分和(1.54±0.41 )分,差异无统计学意义( t =1.12, P =0.41);手术后0.5 h、6 h、12 h、24 h两组患儿FLACC评分差异均无统计学意义( P >0.05)。手术后0.5 h、6 h、12 h、24 h两组患儿Ramsay评分差异均无统计学意义( P >0.05)。盐酸纳布啡组的术后呼吸抑制、恶心呕吐、皮肤瘙痒等不良反应发生率低于舒芬太尼组,差异均有统计学意义( P <0.05)。结论相比于舒芬太尼,盐酸纳布啡更适用于中等疼痛强度手术的术后镇痛。展开更多
OBJECTIVE: To investigate the influence of spleen deficiency on the epithelial barrier of jejunum and lungs in a rat model of spleen-deficiency and the effect and potential specialized pro-resolving mediators (SPMs) m...OBJECTIVE: To investigate the influence of spleen deficiency on the epithelial barrier of jejunum and lungs in a rat model of spleen-deficiency and the effect and potential specialized pro-resolving mediators (SPMs) mechanism of chiropractic manipulation. METHODS: Three-week-old male Sprague-Dawley rats were divided randomly into normal control group (n = 6), spleen-deficiency group (n = 5) and chiropractic group (n = 6). Spleen-deficiency model was induced in spleen-deficiency group and chiropractic group. Moreover, chiropractic manipulation was performed in chiropractic group. Four weeks later, systemic Th1/Th2 balance was evaluated by the ratio of plasma interferon (IFN)-γ/interleukin (IL)-4 levels by enzyme-linked immunosorbent assay (ELISA). Epithelial barrier integrity were assessed by the observation of morphological changes by hematoxylin-eosin staining and zonula occludens (ZO)-1 gene expressions by quantitative real time polymerase chain reaction in jejunum and lungs. Plasma resolvin D1 (RvD1) and lipoxin A4 (LXA4) levels were measures by ELISA for endogenous SPMs production. The levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in jejunum and lungs were also measured by HPLC-MS/ MS. RESULTS: Comparing with normal control group, spleen-deficiency group showed disrupted mucosa in jejunum, inflammatory condition in lungs, significantly decreased ratio of plasma IFN-γ/IL-4 levels and lower expressions of ZO-1 mRNA in both jejunum and lung tissues. Comparing with spleen-deficiency group, chiropractic group had less disrupted mucosa in jejunum and inflammatory condition in lungs, significantly increased systemic ratio of IFN-γ/IL-4 and expressions of ZO-1 mRNA in both jejunum and lung tissues. Chiropractic group had significantly enhanced plasma levels of RvD1 and LXA4, but had no significantly higher levels of DHA and AA in jejunum and lungs when comparing with spleen-deficiency group. CONCLUSION: Spleen deficiency caused systemic Th1/Th2 imbalance towards Th2 polarization and epithelial barrier disruption in jejunum and lungs.Chiropractic manipulation helped enhance endogenous SPMs production, which might be one of the action mechanism of chiropractic manipulation on the improvement of epithelial barrier disruption.展开更多
Prostate cancer(PCa)is one of the most common malignant tumours and a leading cause of cancer deaths.Treatment failure of PCa is often due to bone-metastasis.Celastrol,an active constituent of the roots of Tripterygiu...Prostate cancer(PCa)is one of the most common malignant tumours and a leading cause of cancer deaths.Treatment failure of PCa is often due to bone-metastasis.Celastrol,an active constituent of the roots of Tripterygium wilfordii,has shown antitumour effects in previous studies in accordance with its use in TCM.Here we report for the first time an in-depth study of the effects of celastrol on展开更多
Parenteral nutrition support(PN)is one of the most important developments of the last 40 years for surgical science and practice.It is being utilized for patiens with both surgical and medical gut failure.In our hospi...Parenteral nutrition support(PN)is one of the most important developments of the last 40 years for surgical science and practice.It is being utilized for patiens with both surgical and medical gut failure.In our hospital over the past 22 years,more than 2000 patients have received traditional nutrition support.Diagnoses included perioperative(39％), abdominal infection(18％),gastrointestional fistulae(17％), intensive chemotherapy (9％), inflammoatory bowel disease(6％) and others (11％).Parenteral nutrition support has saved展开更多
文摘目的比较盐酸纳布啡和舒芬太尼对小儿尺桡骨骨折闭合复位克氏针内固定术后的镇痛效果及不良反应,探讨盐酸纳布啡用于术后镇痛的安全性和有效性。方法选取湖南省儿童医院于2017年9月至2018年8月收治的60例尺桡骨骨折需行尺桡骨闭合复位克氏针内固定的患儿为研究对象,依据术后镇痛药物的不同分为盐酸纳布啡组( n =30)和舒芬太尼组( n =30)。比较两组镇痛镇静效果及术后呼吸抑制、恶心呕吐、皮肤瘙痒等不良反应发生率。结果手术前两组患儿的FLACC评分分别为(1.56±0.32)分和(1.54±0.41 )分,差异无统计学意义( t =1.12, P =0.41);手术后0.5 h、6 h、12 h、24 h两组患儿FLACC评分差异均无统计学意义( P >0.05)。手术后0.5 h、6 h、12 h、24 h两组患儿Ramsay评分差异均无统计学意义( P >0.05)。盐酸纳布啡组的术后呼吸抑制、恶心呕吐、皮肤瘙痒等不良反应发生率低于舒芬太尼组,差异均有统计学意义( P <0.05)。结论相比于舒芬太尼,盐酸纳布啡更适用于中等疼痛强度手术的术后镇痛。
基金Supported by the National Natural Science Foundationfunded Project:the Mechanism of Spine-pinching Manipulation via Inflammation Regulation of SPMs on Prevention and Treatment of Spleen-deficiency Asthma(No.81774446)
文摘OBJECTIVE: To investigate the influence of spleen deficiency on the epithelial barrier of jejunum and lungs in a rat model of spleen-deficiency and the effect and potential specialized pro-resolving mediators (SPMs) mechanism of chiropractic manipulation. METHODS: Three-week-old male Sprague-Dawley rats were divided randomly into normal control group (n = 6), spleen-deficiency group (n = 5) and chiropractic group (n = 6). Spleen-deficiency model was induced in spleen-deficiency group and chiropractic group. Moreover, chiropractic manipulation was performed in chiropractic group. Four weeks later, systemic Th1/Th2 balance was evaluated by the ratio of plasma interferon (IFN)-γ/interleukin (IL)-4 levels by enzyme-linked immunosorbent assay (ELISA). Epithelial barrier integrity were assessed by the observation of morphological changes by hematoxylin-eosin staining and zonula occludens (ZO)-1 gene expressions by quantitative real time polymerase chain reaction in jejunum and lungs. Plasma resolvin D1 (RvD1) and lipoxin A4 (LXA4) levels were measures by ELISA for endogenous SPMs production. The levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in jejunum and lungs were also measured by HPLC-MS/ MS. RESULTS: Comparing with normal control group, spleen-deficiency group showed disrupted mucosa in jejunum, inflammatory condition in lungs, significantly decreased ratio of plasma IFN-γ/IL-4 levels and lower expressions of ZO-1 mRNA in both jejunum and lung tissues. Comparing with spleen-deficiency group, chiropractic group had less disrupted mucosa in jejunum and inflammatory condition in lungs, significantly increased systemic ratio of IFN-γ/IL-4 and expressions of ZO-1 mRNA in both jejunum and lung tissues. Chiropractic group had significantly enhanced plasma levels of RvD1 and LXA4, but had no significantly higher levels of DHA and AA in jejunum and lungs when comparing with spleen-deficiency group. CONCLUSION: Spleen deficiency caused systemic Th1/Th2 imbalance towards Th2 polarization and epithelial barrier disruption in jejunum and lungs.Chiropractic manipulation helped enhance endogenous SPMs production, which might be one of the action mechanism of chiropractic manipulation on the improvement of epithelial barrier disruption.
文摘Prostate cancer(PCa)is one of the most common malignant tumours and a leading cause of cancer deaths.Treatment failure of PCa is often due to bone-metastasis.Celastrol,an active constituent of the roots of Tripterygium wilfordii,has shown antitumour effects in previous studies in accordance with its use in TCM.Here we report for the first time an in-depth study of the effects of celastrol on
文摘Parenteral nutrition support(PN)is one of the most important developments of the last 40 years for surgical science and practice.It is being utilized for patiens with both surgical and medical gut failure.In our hospital over the past 22 years,more than 2000 patients have received traditional nutrition support.Diagnoses included perioperative(39％), abdominal infection(18％),gastrointestional fistulae(17％), intensive chemotherapy (9％), inflammoatory bowel disease(6％) and others (11％).Parenteral nutrition support has saved
