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离子液体界面修饰的高效稳定FAPbI_(3)钙钛矿太阳能电池
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作者 Yameen Ahmed 封想想 +8 位作者 高远基 丁洋 龙操玉 Mustafa Haider 李恒月 李专 黄誓成 Makhsud I.Saidaminov 阳军亮 《物理化学学报》 SCIE CAS CSCD 北大核心 2024年第6期34-37,共4页
碘铅甲眯(FAPbI_(3))钙钛矿太阳能电池因其优异的光伏性能而受到广泛关注,但器件的长期稳定性仍然是FAPbI_(3)太阳能电池的关键问题。FAPbI_(3)黑色钙钛矿相在室温下会相变为黄色非钙钛矿相,且水分会加速这一相变。界面工程是提高钙钛... 碘铅甲眯(FAPbI_(3))钙钛矿太阳能电池因其优异的光伏性能而受到广泛关注,但器件的长期稳定性仍然是FAPbI_(3)太阳能电池的关键问题。FAPbI_(3)黑色钙钛矿相在室温下会相变为黄色非钙钛矿相,且水分会加速这一相变。界面工程是提高钙钛矿太阳能电池稳定性的常用方法之一。作为绿色溶剂,离子液体被认为是有毒界面修饰剂的潜在替代品,这也提高了它们的商业可行性,并加速了它们在可再生能源市场的应用。本研究利用具有低挥发性、低毒性、高导电性和高热稳定性的离子液体1-乙基-3-甲基咪唑四氟硼酸盐(EMIM[BF_(4)])来修饰钙钛矿太阳能电池的电子传输层和钙钛矿层之间的界面。离子液体的引入不仅减少了界面缺陷,而且提高了钙钛矿薄膜的质量。密度泛函理论计算表明,离子液体与钙钛矿表面之间存在较强的界面相互作用,有利于降低钙钛矿表面缺陷态密度,稳定钙钛矿晶格。除钙钛矿薄膜缺陷外,溶液处理的SnO_(2)也存在表面缺陷。在SnO_(2)表面的缺陷产生缺陷态,也会导致能带对准问题和稳定性问题。密度泛函理论计算表明,有离子液体的表面间隙态比没有离子液体的表面间隙态小,这种减弱的表面间隙态表明表面区域载流子复合减少,有利于提高器件性能。因此,我们实现了功率转换效率大于22%的离子液体修饰的FAPbI_(3)钙钛矿太阳能电池(对照21%)。在相对湿度~20%的干箱中存放1800h以上后,冠军器件保留了初始状态的~90%,而控制器件降解为非钙钛矿黄色六方相(δ-FAPbI_(3))。 展开更多
关键词 FAPbI_(3) 相稳定性 SnO_(2) 钙钛矿太阳能电池 离子液体 界面工程
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Kallistatin基因在大鼠阴茎海绵体中的表达研究 被引量:1
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作者 转黎 尚坤 +3 位作者 官洁 李云秀 麦选诚 胥琴 《中华男科学杂志》 CAS CSCD 北大核心 2020年第3期223-227,共5页
目的:探讨人组织激肽释放酶结合蛋白(kallistatin)在阴茎海绵体中的表达情况,为勃起功能调控和ED治疗寻找新的分子靶点。方法:采用qRT-PCR、Western印迹和免疫荧光技术检测kallistatin在大鼠阴茎海绵体组织的表达情况,同时检测主动脉中... 目的:探讨人组织激肽释放酶结合蛋白(kallistatin)在阴茎海绵体中的表达情况,为勃起功能调控和ED治疗寻找新的分子靶点。方法:采用qRT-PCR、Western印迹和免疫荧光技术检测kallistatin在大鼠阴茎海绵体组织的表达情况,同时检测主动脉中的表达水平进行对照。结果:qRT-PCR和Western印迹检测结果显示,Kallistatin mRNA和蛋白在大鼠阴茎海绵体组织中均有表达,且其表达水平与主动脉相比均无统计学差异(P>0.05);免疫荧光检测显示,Kallistatin表达于阴茎海绵体内皮细胞和平滑肌细胞,且定位于细胞胞质,与主动脉相比,两者间表达亦无明显差异(P>0.05)。结论:Kallistatin基因高表达于阴茎海绵体且定位于海绵体内皮细胞和平滑肌细胞内,提示kallistatin可能在海绵体内皮细胞和平滑肌细胞的细胞功能中发挥作用,从而参与阴茎勃起功能调控。 展开更多
关键词 Kallistatin基因 阴茎海绵体 勃起功能 勃起功能障碍 大鼠
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干细胞治疗薄型子宫内膜的研究进展 被引量:11
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作者 崔皓 转黎 马艳萍 《医学综述》 2020年第24期4811-4816,共6页
薄型子宫内膜阻碍受精卵在子宫内膜着床和发育,已成为严重影响成年女性生殖健康和困扰临床医师的顽疾之一。目前,临床上治疗薄型子宫内膜的方法较多,但疗效欠佳。干细胞具有无限自我更新和增殖分化为多种细胞类型的能力,包括骨髓间充质... 薄型子宫内膜阻碍受精卵在子宫内膜着床和发育,已成为严重影响成年女性生殖健康和困扰临床医师的顽疾之一。目前,临床上治疗薄型子宫内膜的方法较多,但疗效欠佳。干细胞具有无限自我更新和增殖分化为多种细胞类型的能力,包括骨髓间充质干细胞、子宫内膜干细胞、胚胎干细胞以及诱导多能干细胞等。干细胞可以定向诱导为子宫内膜细胞,而干细胞移植治疗既可改善薄型子宫内膜的子宫内膜厚度,又可改善子宫内膜容受性,在薄型子宫内膜治疗方面有巨大的应用潜能。 展开更多
关键词 薄型子宫内膜 干细胞 干细胞移植
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盐酸贝那普利对TGF-β1诱导的子宫内膜上皮及间质细胞纤维化的保护作用研究 被引量:2
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作者 罗星雨 转黎 +2 位作者 胥琴 田冀雯 马艳萍 《实用药物与临床》 CAS 2022年第7期577-583,共7页
目的探索盐酸贝那普利对转化生长因子β1(TGF-β1)诱导人子宫内膜上皮及间质细胞纤维化的保护作用及其可能机制。方法将人子宫内膜上皮细胞(AN3CA)及人子宫内膜间质细胞(hESC)用TGF-β1诱导纤维化。分为对照组、实验组(TGF-β15 ng/ml处... 目的探索盐酸贝那普利对转化生长因子β1(TGF-β1)诱导人子宫内膜上皮及间质细胞纤维化的保护作用及其可能机制。方法将人子宫内膜上皮细胞(AN3CA)及人子宫内膜间质细胞(hESC)用TGF-β1诱导纤维化。分为对照组、实验组(TGF-β15 ng/ml处理)、BNPL5组(TGF-β15 ng/ml+盐酸贝那普利5μmol/L处理)和BNPL8组(TGF-β15 ng/ml+盐酸贝那普利8μmol/L处理),AN3CA细胞共培养48 h,hESC细胞共培养72 h,镜下观察细胞形态,CellTiter-Glo检测细胞活力,流式细胞仪检测细胞凋亡情况,蛋白质印迹法检测相应纤维化蛋白。结果盐酸贝那普利可部分逆转TGF-β1对AN3CA细胞的形态学改变,hESC细胞经过TGF-β1处理后形态无明显变化;促进TGF-β1诱导后的AN3CA细胞的增殖活力,降低AN3CA细胞凋亡水平(实验组:12.11±0.465,BNPL8组:7.68±0.818,P<0.001);抑制TGF-β1诱导后的hESC细胞的增殖活力,促进其细胞凋亡(实验组:7.553±0.688,BNPL8组:11.047±0.118,P=0.016);盐酸贝那普利诱导后AN3CA及hESC细胞相关纤维化因子Fibronectin、TGF-β1、smad3的表达均有下降。结论盐酸贝那普利可以改善TGF-β1诱导的子宫内膜上皮及间质细胞的纤维化改变。 展开更多
关键词 TGF-Β1 人子宫内膜上皮细胞 人子宫内膜间质细胞 宫腔粘连 盐酸贝那普利
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Tribological properties and thermal-stress analysis of C/C-SiC composites during braking 被引量:10
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作者 Guan-yi CHEN zhuan li +5 位作者 Peng XIAO Xi OUYANG Wen-jie MA Peng-tao li Jin-wei li Yang li 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2019年第1期123-131,共9页
The tribological properties and thermal-stress behaviors of C/C-SiC composites during braking were investigated aiming to simulate braking tests of high-speed trains. The temperature and structural fields of C/C-SiC c... The tribological properties and thermal-stress behaviors of C/C-SiC composites during braking were investigated aiming to simulate braking tests of high-speed trains. The temperature and structural fields of C/C-SiC composites during braking were fully coupled and simulated with ANSYS software. The results of tribological tests indicated that the C/C-SiC composites showed excellent static friction coefficient (0.68) and dynamic friction coefficient (average value of 0.36). The highest temperature on friction surface was 445℃. The simulated temperature field showed that the highest temperature which appeared on the friction surface during braking was about 463℃. Analysis regarding thermal-stress field showed that the highest thermal-stress on friction surface was 11.5 MPa. The temperature and thermal-stress distributions on friction surface during braking showed the same tendency. 展开更多
关键词 C/C-SiC composites BRAKE tribological behavior temperature field thermal-stress field
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Preparation,Properties and Application of C/C-SiC Composites Fabricated by Warm Compacted-in situ Reaction 被引量:8
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作者 Peng Xiao zhuan li +1 位作者 Zibing Zhu Xiang Xiong 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2010年第3期283-288,共6页
Carbon fibre reinforced carbon and SiC dual matrices composites (C/C-SiC) show superior tribological properties,high thermal shock resistance and good abrasive resistance,and they are promising candidates for advanc... Carbon fibre reinforced carbon and SiC dual matrices composites (C/C-SiC) show superior tribological properties,high thermal shock resistance and good abrasive resistance,and they are promising candidates for advanced brake and clutch systems.The microstructure,mechanical properties,friction and wear properties,and application of the C/C-SiC composites fabricated by warm compacted-in situ reaction were introduced.The results indicated that the composites were composed of 50-60 wt pct carbon,2-10 wt pct residual silicon and 30-40 wt pct silicon carbide.The C/C-SiC brake composites exhibited good mechanical properties.The value of flexural strength and compressive strength could reach 160 and 112 MPa,respectively.The impact strength was about 2.5 kJ·m-2.The C/C-SiC brake composites showed excellent tribological performance,including high coefficient of friction (0.38),good abrasive resistance (1.10 μm/cycle) and brake steadily on dry condition.The tribological properties on wet condition could be mostly maintained.The silicon carbide matrix in C/C-SiC brake composites improved the wear resistance,and the graphite played the lubrication function,and right volume content of graphite was helpful to forming friction film to reduce the wear rate.These results showed that C/C-SiC composites fabricated by warm compacted-in situ reaction had excellent properties for use as brake materials. 展开更多
关键词 C/C-SIC Ceramic-matrix composites TRIBOLOGY Warm compacted-in situ reaction
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Generation of Hematopoietic Stem Cells from Purified Embryonic Endothelial Cells by a Simple and Efficient Strategy 被引量:1
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作者 zhuan li Fan Zhou +4 位作者 Dongbo Chen Wenyan He Yanli Ni lingfei Luo Bing liu 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2013年第11期557-563,共7页
Recent progress by versatile approaches supports the new hypothesis that multi-potent hematopoietic stein cells (HSCs) are directly formed from a rare population of endothelial cells in mid-gestation mouse embryos. ... Recent progress by versatile approaches supports the new hypothesis that multi-potent hematopoietic stein cells (HSCs) are directly formed from a rare population of endothelial cells in mid-gestation mouse embryos. This process is therefore known as the endothelial-to- hematopoietic transition (EHT). Nevertheless, there is no functional evidence that documents the HSC transition from purified endothelial cells. In this study, we developed an OP9-DLl-based co-culture system that was able to facilitate the HSC specification and/or expansion in vitro of mouse embryonic day 10.5 (El0.5) Tie2~ cells remarkably. Then, the immunophenotypically defined endothelial ceils were harvested by a combination of surface markers (Flkl+CD31 ~CD41 CD45 Ter119 ) from the caudal half of EI0.0-EI 1.0 mouse embryos. The transplantation of the endothelia/OP9-DL1 co-cultures led to long-term, high-level, multi-lineage, and multi-organ he- matopoietic reconstitution in the irradiated adult recipients. The induced HSC activity was initially observed at El0.5, and a significant increase was detected at El 1.0, which suggests a temporally specific regulation. Taken together, tbr the first time, we provide functional evidence showing the HSC potential of purified embryonic endothelial cells, which is indispensable for the emerging EHT concept. Moreover, the newly defined co-culture system will aid the exploration of the key molecules governing the HSC transition from embryonic and even postnatal endothelial cells, which has enormous significance in basic and translational research. 展开更多
关键词 Hematopoietic stem cells Endothelial-to-hematopoietic transition Endothelial cells Aorta-gonad--mesonephros region
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构建人类辅助生殖技术医联体助力分级诊疗实施 被引量:3
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作者 俞健梅 转黎 +4 位作者 麦选诚 武泽 李云秀 邵静宜 马艳萍 《中华生殖与避孕杂志》 CAS CSCD 北大核心 2019年第10期835-837,共3页
目前我国人类辅助生殖技术医疗资源分布呈"倒金字塔"配置,导致"看病难、看病贵",为此,本文通过云南省第一人民医院人类辅助生殖技术医联体模式的实践,探讨基于医联体助力分级诊疗服务体系实施的对策与建议。首先,... 目前我国人类辅助生殖技术医疗资源分布呈"倒金字塔"配置,导致"看病难、看病贵",为此,本文通过云南省第一人民医院人类辅助生殖技术医联体模式的实践,探讨基于医联体助力分级诊疗服务体系实施的对策与建议。首先,成立专家团队工作站医联体联盟;其次,建立区域医疗卫生信息共享网络;最后,以"基层首诊,双向转诊,急慢分治,上下联动"为核心构建分级诊疗服务体系。本研究通过实证分析,证明该模式能有效促进医疗资源下沉,优化医疗资源的合理配置,能大大减轻患者的经济负担(误工费、差旅费等),大大减少患者就诊的时间成本(路途来回奔波、预处理和前期治疗时间等),使患者享受转诊前后医疗服务的连续性和便捷性,有效缓解了"看病难、看病贵"的问题,同时也增加了当地医疗机构的收入,取得了良好的社会效益。 展开更多
关键词 医联体 分级诊疗 辅助生殖技术
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淋巴细胞相关免疫微环境在子宫内膜异位症中的研究进展 被引量:3
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作者 杜愿(综述) 转黎(综述) +1 位作者 李云秀(综述) 胥琴(审校) 《重庆医学》 CAS 2022年第19期3379-3384,共6页
子宫内膜异位症(EMs)是育龄期女性常见的激素依赖性、炎症性、慢性疾病,表现为有功能活性的子宫内膜细胞出现在子宫腔以外的位置,其典型临床症状如慢性盆腔痛、痛经和不孕等严重影响着患者的生活质量。尽管其发病机制尚未完全清楚,但目... 子宫内膜异位症(EMs)是育龄期女性常见的激素依赖性、炎症性、慢性疾病,表现为有功能活性的子宫内膜细胞出现在子宫腔以外的位置,其典型临床症状如慢性盆腔痛、痛经和不孕等严重影响着患者的生活质量。尽管其发病机制尚未完全清楚,但目前发现全身和局部免疫相关细胞的功能异常在其病因、病理生理学和临床表现中起着重要作用。近年来,许多研究证实子宫内膜微环境中多种免疫细胞和细胞因子的变化可能与EMs的发生有关。本文总结并分析EMs免疫微环境中淋巴细胞的分布及功能作用,进而能更好地认识EMs的发生、发展。 展开更多
关键词 子宫内膜异位症 免疫微环境 淋巴细胞 子宫内膜 综述
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Microstructures and mechanical behaviors of CVI-based C/C composites containing h-BN powdered additives 被引量:1
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作者 Peng Xiao Zhichao li +4 位作者 Zeyan liu zhuan li Bengu Zhang Jinwei li Yang li 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2019年第12期2824-2831,共8页
Hexagonal boron nitride(h-BN) powders were introduced into carbon fiber preform by powder addition and subsequent combined with chemical vapor infiltration(CVI) for densification to prepare carbon fiber reinforced/car... Hexagonal boron nitride(h-BN) powders were introduced into carbon fiber preform by powder addition and subsequent combined with chemical vapor infiltration(CVI) for densification to prepare carbon fiber reinforced/carbon and boron nitride dual matrix composites(C/C-BN). Microstructures and mechanical properties of C/C composites with three different volume contents of h-BN powders were investigated in comparison to pure C/C composites. Results indicated that the introduction of h-BN powders into C/C composites significantly reduced the size of Py C and the anisotropy of thermal contraction in matrix,leading to a gradual disappearance of ring defects as the h-BN content increased. In addition, an enhanced interfacial bonding between fiber and matrix obtained due to higher-textured Py C and rougher fiber surface. Thereby, the flexural strengths and modulus of as-prepared composites decreased firstly and then increased, while the impact toughness presented a decreasing tendency as the content of BN powders increased. Furthermore, with the increasing of h-BN content, anisotropies of compressive properties were weakened, and the compressive strength of C/C-BN composites were always higher than that of pure C/C composit. However, when C/C composites modified by 13.5 vol% content of h-BN, excessive loose BN aggregates appeared in C/C-BN composites, leading to a relatively slight reduction of compressive strength. 展开更多
关键词 C/C composites H-BN Pyrolytic carbon Interfacial bonding Mechanical properties
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冷冻胚胎移植中替代周期致妊娠期高血压的风险增加及可能机制研究进展
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作者 罗星雨(综述) 胥琴 +1 位作者 转黎 马艳萍(审校) 《重庆医学》 CAS 2022年第13期2316-2320,共5页
冷冻胚胎移植(FET)是人类辅助生殖技术中的重要技术,FET中子宫内膜的准备方法分为自然周期、改良自然周期和替代周期。大量研究发现,使用替代周期孕妇较使用自然周期孕妇发生妊娠期高血压(HDP)的风险增加。目前认为其发生的可能机制与... 冷冻胚胎移植(FET)是人类辅助生殖技术中的重要技术,FET中子宫内膜的准备方法分为自然周期、改良自然周期和替代周期。大量研究发现,使用替代周期孕妇较使用自然周期孕妇发生妊娠期高血压(HDP)的风险增加。目前认为其发生的可能机制与黄体缺失和子宫内膜处于非生理的激素环境有关。该文对替代周期与HDP的相关性及可能机制做一综述。 展开更多
关键词 妊娠期高血压 冷冻胚胎移植 替代周期 黄体缺失 松弛素
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