Previous studies revealed that the deficiency of the nuclear localization sequence(NLS)and C terminus of parathyroid hormone related peptide(PTHrP)mice(i.e.,PTHrP KI mice)exhibited the decreased proliferation and incr...Previous studies revealed that the deficiency of the nuclear localization sequence(NLS)and C terminus of parathyroid hormone related peptide(PTHrP)mice(i.e.,PTHrP KI mice)exhibited the decreased proliferation and increased apoptosis of oligodendrocyte progenitor cells(OPCs),and resulted in the disability of axonal myelination in brain.Meanwhile,the oxidative stress and DNA damage response(DDR)was increased in OPCs from the PTHrP KI mice.展开更多
文摘Previous studies revealed that the deficiency of the nuclear localization sequence(NLS)and C terminus of parathyroid hormone related peptide(PTHrP)mice(i.e.,PTHrP KI mice)exhibited the decreased proliferation and increased apoptosis of oligodendrocyte progenitor cells(OPCs),and resulted in the disability of axonal myelination in brain.Meanwhile,the oxidative stress and DNA damage response(DDR)was increased in OPCs from the PTHrP KI mice.