以Web of Science收录的文献题录作为数据样本,基于文献计量学方法并利用CiteSpace工具对1990-2019年计算机视觉领域的文献进行可视化分析,从时空层面揭示计算机视觉领域在不同国家(地区)、机构的发展程度;从共引文献层面把握计算机视...以Web of Science收录的文献题录作为数据样本,基于文献计量学方法并利用CiteSpace工具对1990-2019年计算机视觉领域的文献进行可视化分析,从时空层面揭示计算机视觉领域在不同国家(地区)、机构的发展程度;从共引文献层面把握计算机视觉发展脉络;从关键词和突变词角度探测计算机视觉的热点前沿。研究结果显示,从全球范围看,美国对计算机视觉的研究起步较早且一直处于领先地位,中国近年来发展迅速且在总体发文量、高校研究力量层面进步明显,英国、法国、日本、加拿大、瑞士等国近年来发展态势也较突出;马尔视觉计算理论、Canny边缘检测算法、张氏标定法、YOLO算法等许多经典算法对计算机视觉领域的发展具有里程碑式的意义;模型、分类、图像分割、追踪、识别等方向是计算机视觉领域的热点话题;深度学习、卷积神经网络、压缩感知、机器学习是计算机视觉领域近10年的前沿研究方向。展开更多
The cause of asthenozoospermia(AZS)is not well understood because of its complexity and heterogeneity.Although some gene mutations have been identified as contributing factors,they are only responsible for a small num...The cause of asthenozoospermia(AZS)is not well understood because of its complexity and heterogeneity.Although some gene mutations have been identified as contributing factors,they are only responsible for a small number of cases.Radial spokes(RSs)are critical for adenosine triphosphate-driven flagellar beating and axoneme stability,which is essential for flagellum motility.In this study,we found novel compound heterozygous mutations in leucine-rich repeat-containing protein 23(LRRC23;c.1018C>T:p.Q340X and c.881_897 Del:p.R295Gfs*32)in a proband from a nonconsanguineous family with AZS and male infertility.Diff-Quik staining and scanning electron microscopy revealed no abnormal sperm morphology.Western blotting and immunofluorescence staining showed that these mutations suppressed LRRC23 expression in sperm flagella.Additionally,transmission electron microscopy showed the absence of RS3 in sperm flagella,which disrupts stability of the radial spoke complex and impairs motility.Following in vitro fertilization and embryo transfer,the proband’s spouse achieved successful pregnancy and delivered a healthy baby.In conclusion,our study indicates that two novel mutations in LRRC23 are associated with AZS,but successful fertility outcomes can be achieved by in vitro fertilization-embryo transfer techniques.展开更多
文摘以Web of Science收录的文献题录作为数据样本,基于文献计量学方法并利用CiteSpace工具对1990-2019年计算机视觉领域的文献进行可视化分析,从时空层面揭示计算机视觉领域在不同国家(地区)、机构的发展程度;从共引文献层面把握计算机视觉发展脉络;从关键词和突变词角度探测计算机视觉的热点前沿。研究结果显示,从全球范围看,美国对计算机视觉的研究起步较早且一直处于领先地位,中国近年来发展迅速且在总体发文量、高校研究力量层面进步明显,英国、法国、日本、加拿大、瑞士等国近年来发展态势也较突出;马尔视觉计算理论、Canny边缘检测算法、张氏标定法、YOLO算法等许多经典算法对计算机视觉领域的发展具有里程碑式的意义;模型、分类、图像分割、追踪、识别等方向是计算机视觉领域的热点话题;深度学习、卷积神经网络、压缩感知、机器学习是计算机视觉领域近10年的前沿研究方向。
基金supported by the National Key Research and Development Program of China(No.2022YFC2702702)National Natural Science Foundation of China(No.32270899 and No.32070842)+2 种基金the Natural Science Foundation of Jiangsu Province(No.BK20230004)Young and Middle-Aged Key Personnel Training Project of the Fujian Provincial Health Commission(2019-ZQN-62)Fujian Provincial Finance Project(BPB-TSX2021).
文摘The cause of asthenozoospermia(AZS)is not well understood because of its complexity and heterogeneity.Although some gene mutations have been identified as contributing factors,they are only responsible for a small number of cases.Radial spokes(RSs)are critical for adenosine triphosphate-driven flagellar beating and axoneme stability,which is essential for flagellum motility.In this study,we found novel compound heterozygous mutations in leucine-rich repeat-containing protein 23(LRRC23;c.1018C>T:p.Q340X and c.881_897 Del:p.R295Gfs*32)in a proband from a nonconsanguineous family with AZS and male infertility.Diff-Quik staining and scanning electron microscopy revealed no abnormal sperm morphology.Western blotting and immunofluorescence staining showed that these mutations suppressed LRRC23 expression in sperm flagella.Additionally,transmission electron microscopy showed the absence of RS3 in sperm flagella,which disrupts stability of the radial spoke complex and impairs motility.Following in vitro fertilization and embryo transfer,the proband’s spouse achieved successful pregnancy and delivered a healthy baby.In conclusion,our study indicates that two novel mutations in LRRC23 are associated with AZS,but successful fertility outcomes can be achieved by in vitro fertilization-embryo transfer techniques.
