Asphalt extraction test and scanning electron microscopy(SEM) were used for analysis of agglomerations of reclaimed asphalt pavement(RAP) particles. In order to quantify the agglomeration degree of RAP, the fineness m...Asphalt extraction test and scanning electron microscopy(SEM) were used for analysis of agglomerations of reclaimed asphalt pavement(RAP) particles. In order to quantify the agglomeration degree of RAP, the fineness modulus ratio(FMR) and the percentage loss index(PLI) were proposed. In addition, grey correlation analysis was conducted to discuss the relationship between particle agglomerations and RAP size,asphalt content(AC), and surface area. Two indexes indicate that the agglomeration degree increases in general as the RAP size reduces. This can be attributed to that particles are prone to agglomeration in the case of higher AC. Based on the SEM images and the material composition of RAP, the particle agglomeration in RAP can be classified into weak agglomeration and strong agglomeration. Grey correlation analysis shows that AC is the crucial factor affecting the agglomeration degree and RAP variability. In order to produce consistent and stable reclaimed mixtures, disposal measures of RAP are suggested to lower the AC of RAP.展开更多
目的探讨黑龙江地区脑梗死患者接受氯吡格雷治疗时CYP2C19基因多态性对治疗效果的影响。方法选取2022年1—12月在黑龙江省医院神经内科住院的90例脑梗死患者为研究对象。检测CYP2C19基因多态性,根据检测结果,将患者分为3组,快代谢组(n=...目的探讨黑龙江地区脑梗死患者接受氯吡格雷治疗时CYP2C19基因多态性对治疗效果的影响。方法选取2022年1—12月在黑龙江省医院神经内科住院的90例脑梗死患者为研究对象。检测CYP2C19基因多态性,根据检测结果,将患者分为3组,快代谢组(n=26)、中等代谢组(n=52)和慢代谢组(n=12)。所有患者均给予氯吡格雷治疗,对美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分及预后情况进行观察对比。结果在脑梗死患者中以快代谢型和中等代谢型为主要类型。治疗2周后,3组NIHSS评分低于治疗前,差异有统计学意义(P<0.05);且快代谢组评分为(6.23±1.38)分,低于中等代谢组、慢代谢组的(7.76±1.71)分、(10.12±1.29)分,差异有统计学意义(P<0.05);快代谢组和中等代谢组预后良好率高于慢代谢组(P<0.05);快代谢组、中等代谢组和慢代谢组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论通过对老年脑梗死患者行CYP2C19基因型检测来评估对氯吡格雷治疗的药物代谢能力和反应情况。有助于制定个体化的治疗方案,提高治疗效果并降低不良反应的发生率,可以最大限度地提高治疗效果,减少风险发生。展开更多
基金Funded by the Postgraduate Research and Practice Innovation Program of Jiangsu Province (No.KYCX21_0496)the Fundamental Research Funds for the Central Universities (for student)+1 种基金the Fundamental Research Funds for the Central Universities (No.B210202050)the Scientific Research Project of Jiangsu Communications Holding Co.,Ltd (No.JETC-DLJS-2022-001)。
文摘Asphalt extraction test and scanning electron microscopy(SEM) were used for analysis of agglomerations of reclaimed asphalt pavement(RAP) particles. In order to quantify the agglomeration degree of RAP, the fineness modulus ratio(FMR) and the percentage loss index(PLI) were proposed. In addition, grey correlation analysis was conducted to discuss the relationship between particle agglomerations and RAP size,asphalt content(AC), and surface area. Two indexes indicate that the agglomeration degree increases in general as the RAP size reduces. This can be attributed to that particles are prone to agglomeration in the case of higher AC. Based on the SEM images and the material composition of RAP, the particle agglomeration in RAP can be classified into weak agglomeration and strong agglomeration. Grey correlation analysis shows that AC is the crucial factor affecting the agglomeration degree and RAP variability. In order to produce consistent and stable reclaimed mixtures, disposal measures of RAP are suggested to lower the AC of RAP.
文摘目的探讨黑龙江地区脑梗死患者接受氯吡格雷治疗时CYP2C19基因多态性对治疗效果的影响。方法选取2022年1—12月在黑龙江省医院神经内科住院的90例脑梗死患者为研究对象。检测CYP2C19基因多态性,根据检测结果,将患者分为3组,快代谢组(n=26)、中等代谢组(n=52)和慢代谢组(n=12)。所有患者均给予氯吡格雷治疗,对美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分及预后情况进行观察对比。结果在脑梗死患者中以快代谢型和中等代谢型为主要类型。治疗2周后,3组NIHSS评分低于治疗前,差异有统计学意义(P<0.05);且快代谢组评分为(6.23±1.38)分,低于中等代谢组、慢代谢组的(7.76±1.71)分、(10.12±1.29)分,差异有统计学意义(P<0.05);快代谢组和中等代谢组预后良好率高于慢代谢组(P<0.05);快代谢组、中等代谢组和慢代谢组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论通过对老年脑梗死患者行CYP2C19基因型检测来评估对氯吡格雷治疗的药物代谢能力和反应情况。有助于制定个体化的治疗方案,提高治疗效果并降低不良反应的发生率,可以最大限度地提高治疗效果,减少风险发生。
