The blood system originates from hematopoietic stem cells(HSCs),capable of self-renewal and differentiation,generating diverse blood cell types(Eaves,2015;Lucas,2021).The concept of the hematopoietic niche was first p...The blood system originates from hematopoietic stem cells(HSCs),capable of self-renewal and differentiation,generating diverse blood cell types(Eaves,2015;Lucas,2021).The concept of the hematopoietic niche was first proposed in 1978(Schofield,1978),which is crucial for maintaining hematopoietic balance.The following studies,particularly in mammals,have utilized targeted genetic manipulation to identify and define these niches.展开更多
基金supported by the National Key Research and Development Program of China(2018YFA0800200)the National Natural Science Foundation of China/ResearchGrantsCouncilJointResearchScheme(31961160726)+1 种基金the National Natural Science Foundation of China(32170827 and 32370886)the Research Grants Council of Hong Kong(RGC/NFSC N_HKUST603/19).
文摘The blood system originates from hematopoietic stem cells(HSCs),capable of self-renewal and differentiation,generating diverse blood cell types(Eaves,2015;Lucas,2021).The concept of the hematopoietic niche was first proposed in 1978(Schofield,1978),which is crucial for maintaining hematopoietic balance.The following studies,particularly in mammals,have utilized targeted genetic manipulation to identify and define these niches.
