Development of a large nanocrystalline soft magnetic alloy core with highμ'_(p)Qf products for CSNS-Ⅱ

A waterproof nanocrystalline soft magnetic alloy core with a size of O.D.850 mm×I.D.316 mm×H.25 mm for radio frequency acceleration was successfully developed by winding 18μm 1k107b MA ribbons.Theμ'_(p)Qf products reached 7.5,10,and 12 GHz at 1,3,and 5 MHz,respectively.Theμ'_(p)Qf products of the MA core(O.D.250 mm×I.D.100 mm×H.25 mm)manufactured using a 13μm MA ribbon further increased by 30%.Detailed improvements on the MA core manufacture process are discussed herein.Continuous high-power tests on the new MA cores demonstrated its good performance of waterproofness,particularly its stability of highμ'_(p)Qf products.The MA core with highμ'pQf product and large size can operate under a high average RF power,high electric field,and in deionized water,which will be used in the China Spallation Neutron Source PhaseⅡ(CSNS-Ⅱ).

Buckling of composite cylindrical shells with ovality and thickness variation subjected to hydrostatic pressure

The initial geometric imperfection is one of the primary factors affecting the buckling behaviors of composite cylindrical shells under hydrostatic pressure.In this study,ovality and thickness variations as two representative types of the geometric imperfections are considered.After measuring the geometric imperfections,a typical carbon fiber reinforced polymers(CFRP)cylindrical shell is tested to obtain the buckling pressure.The buckling behaviors of the shell sample are analyzed in combination with the strain responses.By using the nonlinear numerical analysis,the buckling shapes of the CFRP cylinder shells with different combinations of ovality and thickness variation are firstly discussed.The rules of influence of such imperfections on the buckling pressure are then obtained by nonlinear regression method.Finally,an empirical formula is proposed to predict the buckling pressure of the composite cylinder shells,and the calculated results from the formula are in good agreement with the numerical results.

Role of mesenteric component in Crohn’s disease:A friend or foe?

Crohn’s disease(CD)is a complex and relapsing gastrointestinal disease with mesenteric alterations.The mesenteric neural,vascular,and endocrine systems actively take part in the gut dysbiosis-adaptive immunity-mesentery-body axis,and this axis has been proven to be bidirectional.The abnormalities of morphology and function of the mesenteric component are associated with intestinal inflammation and disease progress of CD via responses to afferent signals,neuropeptides,lymphatic drainage,adipokines,and functional cytokines.The hypertrophy of mesenteric adipose tissue plays important roles in the pathogenesis of CD by secreting large amounts of adipokines and representing a rich source of proinflammatory or profibrotic cytokines.The vascular alteration,including angiogenesis and lymphangiogenesis,is concomitant in the disease course of CD.Of note,the enlarged and obstructed lymphatic vessels,which have been described in CD patients,are likely related to the early onset submucosa edema and being a cause of CD.The function of mesenteric lymphatics is influenced by endocrine of mesenteric nerves and adipocytes.Meanwhile,the structure of the mesenteric lymphatic vessels in hypertrophic mesenteric adipose tissue is mispatterned and ruptured,which can lead to lymph leakage.Leaky lymph factors can in turn stimulate adipose tissue to proliferate and effectively elicit an immune response.The identification of the role of mesentery and the crosstalk between mesenteric tissues in intestinal inflammation may shed light on understanding the underlying mechanism of CD and help explore new therapeutic targets.

Case Analysis of a Pump-Driven Heat Pipe Heat Recovery Ventilator in an Existing Experiment Building

The building energy consumption is an important part among the total society energy consumption,in which the energy consumption for air conditioning occupies almost 70%.The energy consumption of the air conditioning system for fresh air handling can be saved effectively when the exhaust air energy could be recovered to preheat or precool the fresh air.Considering the install locations requirements on field,the pump-driven heat pipes(PHP)were developed as heat recovery ventilators(HRVs)and used in an existing experiment building in Beijing Urban.The thermal performance of the PHP HRVs was tested in real operation time periods under winter running mode.Both the power and heat consumption of the modular air handling units with and without HRVs were monitored and obtained,as well as the hourly power and heat consumption.The energy savings of HRVs were analyzed.The results indicate that the PHP HRVs can work steadily and meet the energy recovery need well.The temperature effectiveness of the HRVs can be kept from 60%to 70%.The test total energy saving rate was 24.48%,and the average hourly heat consumption reduced by 28.54%.The daily energy consumption can be saved by 118 kWh,and the energy savings can reach to 9440 kWh for a whole winter.

Fe-based metallic glass as heterogeneous Fenton-like catalyst for azo dyes degradation:effect of inorganic anions

Metallic glasses(MGs) are promising heterogeneous catalysts in water remediation,due to their superior efficiency,selectivity,reusability and corrosion resistance.However,few works are focused on the influence of inorganic anions that are abundant in wastewater.Herein,four common inorganic anions were added in a heterogeneous Fenton-like system(Fe-MG/H_(2)O_(2)) to study inorganic anions' influence on MGs' catalytic performance during methylene blue(MB) degradation.Evidence demonstrated that chloride ions and dihydrogen phosphate ions had an adverse effect on the catalytic performance of Fe-MG,whereas Fe-MG/H_(2)O_(2) system sustained high efficiency in the presence of sulfate ions and nitrate ions during the Fenton-like process.By studying the structure,surface morphology,and evolution of active species,it was found that inorganic anions had a significant effect on the surface morphology of Fe-MG and the generation of active species.This work will provide essential references for MGs as heterogeneous catalysts in practical applications.

Oral pyroptosis nanoinhibitor for the treatment of inflammatory bowel disease

Inflammatory bowel disease(IBD)is an autoimmune gastrointestinal disease characterized by chronic relapsing inflammation of the intestine.Excessive pyroptosis that exists in the inflamed intestine can activate damage signals and aggravate local inflammation in IBD.Here,we designed an oral pyroptosis nanoinhibitor,DXMS@CuM@PPADT@PSS(DCMP),which can target intestinal lesions,and respond to reactive oxygen species(ROS)to release active sites and drugs at the lesion.DCMP can inhibit the activation of the nucleotide-binding domain and leucine-rich repeat family pyrin domain containing 3(NLRP3)inflammasomes by scavenging ROS,resulting in the down-regulation of gasdermin D(GSDMD)cleavage thus inhibiting pyroptosis.It also improved intestinal barrier function,decreased inflammatory cytokine levels,and increased the diversity of gut microbiota in mice with colitis.This work is believed to expand the biomedical application of nanomaterials for innate immunity modulation.

Fe-based multi-phase nanocrystalline ribbons with hierarchically flowerlike structured metal oxides after modified by Orange II for Cr^VI absorption

Three-dimensional flowerlike nanostructured metal oxides attached on the surfaces of Fe-based multi-phase nanocrys- talline ribbons （Fe-MNRs） were prepared by a simple way （through immersing the Fe-MNRs in Orange II solution）. It has been found that the as-prepared Fe-MNRs with 3D flowerlike nanostructures （Fe-MNRs ＋ FNs） exhibit good absorption property for a typical heavy metal ion （Cr^VI） in wastewater, while Fe-MNRs do not possess such properties. The Fe-MNRs ＋ FNs could remove 99% CrvI ions from the solution in 40 min, and this adsorption property can be attributed to the ion exchange between Cr^VI and surface hydroxyl groups （O-H） of 3D flowerlike nanostructures. The present result suggests that the Fe-MNRs ＋ FNs, prepared by facile way, possess great potentials in removing heavy metallic ions in wastewater.

Erratum to:Excellent long-term reactivity of inhomogeneous nanoscale Fe-based metallic glass in wastewater purification(vol 63,issue 3,pg 453-466,2020)

In the version of the article originally published in the volume 63,ssue 3,2020 of Sci China Mater(2020,63(3):453-46,https:/doi.org/10.1007/s40843-019-1205-5),the affiliations of the authors were incorrectly labeled.

Contraction flexibility, operating leverage, and financial leverage

This study investigates the impacts of contraction flexibility and operating leverage onfinancial leverage from the perspective of the agency conflict between shareholders and debtholders.In a continuous-time real option framework,we demonstrate that share-holders'contraction flexibility may have an adverse effect on financial leverage,and that the substitution relation between operating leverage andfinancial leverage is persistent or pronounced in the presence of contraction flexibility.The evidence from Chinese listedfirms not only supports our theoretical predictions well,but also offers a method to examine the agency conflict hypothesis.We suggest that the high proportion of bank loans or long-term debt in total liabilities can help levered firms alleviate the agency problem arising from contraction decisions.

纳米尺度非均匀性诱导自更新铁基非晶合金具有优异的长期反应活性（英文）

铁基非晶合金作为亚稳态新型零价铁,具有高活性亚稳态结构、较大的残余应力和高密度低配位点等特性,在催化和废水处理中引起了广泛的关注;但由于腐蚀产物沉淀覆盖活性位点,非晶合金的反应活性随着时间的推移而逐渐降低,导致耐用性差.腐蚀产物沉淀造成长期反应活性降低也是阻碍传统晶态零价铁技术在废水处理领域应用的主要问题之一.本文通过在铁基非晶合金中引入纳米尺度的化学不均匀性,有助于构成局部原电池效应,加速电子在降解过程中的转移,可以有效地克服这一问题.更重要的是,非晶合金中的零价铁被选择性腐蚀/脱合金,导致反应区域局部体积收缩和裂纹形成,裂纹扩展使沉淀腐蚀产物和反应区域自剥落.因此,可以连续提供新的低配位,消除质量传递和反应活性恶化的问题.本文所制备的具有成分不均匀的铁基非晶合金即使在中性溶液中也具有良好的长期反应活性和自更新性能.研究结果不仅为废水处理提供了一种新材料,而且为设计高活性零价铁材料提供了一种新思路.

Amorphous FeNiCoCuSiBCr Alloys with Superior Direct Current Tolerant Characteristics

Amorphous Fe62-x Ni19CoxCu0.1 Si3.8B14Cr1. 1 （x=0, 1, 5, 10） ribbons were annealed under magnetic field and tensile stress, respectively, and their magnetic properties were investigated. Fe73.5 Cu1 Nb3 Si15.5 B7 and Fe66 Ni10- Cu1 Nb3Si11 B9 nanocrystalline alloy ribbons were also fabricated for comparison. Excellent DC tolerant property was obtained in the amorphous FeNiCoCuSiBCr ribbons after thermomagnetic treatment and the constant permeable property was improved with increasing Co content. The relative permeability was constant up to the DC bias field of approximately 6 ×10 ^-4 , 9 ×10 ^-4, and 10 × 10^-4 T and the values of relative permeability μ were 1 650, 1 200, and 1 000 with the Co content being 0, 5 at. %, and 10 at.%, respectively. Besides, stress-annealed FeNiCoCuSiBCr al- loy ribbons were proved to exhibit positive saturation magnetostriction constant λs.

Alteration of the respiratory microbiome in COVID-19 patients with different severities

Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients.