A waterproof nanocrystalline soft magnetic alloy core with a size of O.D.850 mm×I.D.316 mm×H.25 mm for radio frequency acceleration was successfully developed by winding 18μm 1k107b MA ribbons.Theμ'_(p...A waterproof nanocrystalline soft magnetic alloy core with a size of O.D.850 mm×I.D.316 mm×H.25 mm for radio frequency acceleration was successfully developed by winding 18μm 1k107b MA ribbons.Theμ'_(p)Qf products reached 7.5,10,and 12 GHz at 1,3,and 5 MHz,respectively.Theμ'_(p)Qf products of the MA core(O.D.250 mm×I.D.100 mm×H.25 mm)manufactured using a 13μm MA ribbon further increased by 30%.Detailed improvements on the MA core manufacture process are discussed herein.Continuous high-power tests on the new MA cores demonstrated its good performance of waterproofness,particularly its stability of highμ'_(p)Qf products.The MA core with highμ'pQf product and large size can operate under a high average RF power,high electric field,and in deionized water,which will be used in the China Spallation Neutron Source PhaseⅡ(CSNS-Ⅱ).展开更多
The initial geometric imperfection is one of the primary factors affecting the buckling behaviors of composite cylindrical shells under hydrostatic pressure.In this study,ovality and thickness variations as two repres...The initial geometric imperfection is one of the primary factors affecting the buckling behaviors of composite cylindrical shells under hydrostatic pressure.In this study,ovality and thickness variations as two representative types of the geometric imperfections are considered.After measuring the geometric imperfections,a typical carbon fiber reinforced polymers(CFRP)cylindrical shell is tested to obtain the buckling pressure.The buckling behaviors of the shell sample are analyzed in combination with the strain responses.By using the nonlinear numerical analysis,the buckling shapes of the CFRP cylinder shells with different combinations of ovality and thickness variation are firstly discussed.The rules of influence of such imperfections on the buckling pressure are then obtained by nonlinear regression method.Finally,an empirical formula is proposed to predict the buckling pressure of the composite cylinder shells,and the calculated results from the formula are in good agreement with the numerical results.展开更多
Crohn’s disease(CD)is a complex and relapsing gastrointestinal disease with mesenteric alterations.The mesenteric neural,vascular,and endocrine systems actively take part in the gut dysbiosis-adaptive immunity-mesent...Crohn’s disease(CD)is a complex and relapsing gastrointestinal disease with mesenteric alterations.The mesenteric neural,vascular,and endocrine systems actively take part in the gut dysbiosis-adaptive immunity-mesentery-body axis,and this axis has been proven to be bidirectional.The abnormalities of morphology and function of the mesenteric component are associated with intestinal inflammation and disease progress of CD via responses to afferent signals,neuropeptides,lymphatic drainage,adipokines,and functional cytokines.The hypertrophy of mesenteric adipose tissue plays important roles in the pathogenesis of CD by secreting large amounts of adipokines and representing a rich source of proinflammatory or profibrotic cytokines.The vascular alteration,including angiogenesis and lymphangiogenesis,is concomitant in the disease course of CD.Of note,the enlarged and obstructed lymphatic vessels,which have been described in CD patients,are likely related to the early onset submucosa edema and being a cause of CD.The function of mesenteric lymphatics is influenced by endocrine of mesenteric nerves and adipocytes.Meanwhile,the structure of the mesenteric lymphatic vessels in hypertrophic mesenteric adipose tissue is mispatterned and ruptured,which can lead to lymph leakage.Leaky lymph factors can in turn stimulate adipose tissue to proliferate and effectively elicit an immune response.The identification of the role of mesentery and the crosstalk between mesenteric tissues in intestinal inflammation may shed light on understanding the underlying mechanism of CD and help explore new therapeutic targets.展开更多
The building energy consumption is an important part among the total society energy consumption,in which the energy consumption for air conditioning occupies almost 70%.The energy consumption of the air conditioning s...The building energy consumption is an important part among the total society energy consumption,in which the energy consumption for air conditioning occupies almost 70%.The energy consumption of the air conditioning system for fresh air handling can be saved effectively when the exhaust air energy could be recovered to preheat or precool the fresh air.Considering the install locations requirements on field,the pump-driven heat pipes(PHP)were developed as heat recovery ventilators(HRVs)and used in an existing experiment building in Beijing Urban.The thermal performance of the PHP HRVs was tested in real operation time periods under winter running mode.Both the power and heat consumption of the modular air handling units with and without HRVs were monitored and obtained,as well as the hourly power and heat consumption.The energy savings of HRVs were analyzed.The results indicate that the PHP HRVs can work steadily and meet the energy recovery need well.The temperature effectiveness of the HRVs can be kept from 60%to 70%.The test total energy saving rate was 24.48%,and the average hourly heat consumption reduced by 28.54%.The daily energy consumption can be saved by 118 kWh,and the energy savings can reach to 9440 kWh for a whole winter.展开更多
Metallic glasses(MGs) are promising heterogeneous catalysts in water remediation,due to their superior efficiency,selectivity,reusability and corrosion resistance.However,few works are focused on the influence of inor...Metallic glasses(MGs) are promising heterogeneous catalysts in water remediation,due to their superior efficiency,selectivity,reusability and corrosion resistance.However,few works are focused on the influence of inorganic anions that are abundant in wastewater.Herein,four common inorganic anions were added in a heterogeneous Fenton-like system(Fe-MG/H_(2)O_(2)) to study inorganic anions' influence on MGs' catalytic performance during methylene blue(MB) degradation.Evidence demonstrated that chloride ions and dihydrogen phosphate ions had an adverse effect on the catalytic performance of Fe-MG,whereas Fe-MG/H_(2)O_(2) system sustained high efficiency in the presence of sulfate ions and nitrate ions during the Fenton-like process.By studying the structure,surface morphology,and evolution of active species,it was found that inorganic anions had a significant effect on the surface morphology of Fe-MG and the generation of active species.This work will provide essential references for MGs as heterogeneous catalysts in practical applications.展开更多
Inflammatory bowel disease(IBD)is an autoimmune gastrointestinal disease characterized by chronic relapsing inflammation of the intestine.Excessive pyroptosis that exists in the inflamed intestine can activate damage ...Inflammatory bowel disease(IBD)is an autoimmune gastrointestinal disease characterized by chronic relapsing inflammation of the intestine.Excessive pyroptosis that exists in the inflamed intestine can activate damage signals and aggravate local inflammation in IBD.Here,we designed an oral pyroptosis nanoinhibitor,DXMS@CuM@PPADT@PSS(DCMP),which can target intestinal lesions,and respond to reactive oxygen species(ROS)to release active sites and drugs at the lesion.DCMP can inhibit the activation of the nucleotide-binding domain and leucine-rich repeat family pyrin domain containing 3(NLRP3)inflammasomes by scavenging ROS,resulting in the down-regulation of gasdermin D(GSDMD)cleavage thus inhibiting pyroptosis.It also improved intestinal barrier function,decreased inflammatory cytokine levels,and increased the diversity of gut microbiota in mice with colitis.This work is believed to expand the biomedical application of nanomaterials for innate immunity modulation.展开更多
Three-dimensional flowerlike nanostructured metal oxides attached on the surfaces of Fe-based multi-phase nanocrys- talline ribbons (Fe-MNRs) were prepared by a simple way (through immersing the Fe-MNRs in Orange I...Three-dimensional flowerlike nanostructured metal oxides attached on the surfaces of Fe-based multi-phase nanocrys- talline ribbons (Fe-MNRs) were prepared by a simple way (through immersing the Fe-MNRs in Orange II solution). It has been found that the as-prepared Fe-MNRs with 3D flowerlike nanostructures (Fe-MNRs + FNs) exhibit good absorption property for a typical heavy metal ion (Cr^VI) in wastewater, while Fe-MNRs do not possess such properties. The Fe-MNRs + FNs could remove 99% CrvI ions from the solution in 40 min, and this adsorption property can be attributed to the ion exchange between Cr^VI and surface hydroxyl groups (O-H) of 3D flowerlike nanostructures. The present result suggests that the Fe-MNRs + FNs, prepared by facile way, possess great potentials in removing heavy metallic ions in wastewater.展开更多
In the version of the article originally published in the volume 63,ssue 3,2020 of Sci China Mater(2020,63(3):453-46,https:/doi.org/10.1007/s40843-019-1205-5),the affiliations of the authors were incorrectly labeled.
This study investigates the impacts of contraction flexibility and operating leverage onfinancial leverage from the perspective of the agency conflict between shareholders and debtholders.In a continuous-time real opt...This study investigates the impacts of contraction flexibility and operating leverage onfinancial leverage from the perspective of the agency conflict between shareholders and debtholders.In a continuous-time real option framework,we demonstrate that share-holders'contraction flexibility may have an adverse effect on financial leverage,and that the substitution relation between operating leverage andfinancial leverage is persistent or pronounced in the presence of contraction flexibility.The evidence from Chinese listedfirms not only supports our theoretical predictions well,but also offers a method to examine the agency conflict hypothesis.We suggest that the high proportion of bank loans or long-term debt in total liabilities can help levered firms alleviate the agency problem arising from contraction decisions.展开更多
Amorphous Fe62-x Ni19CoxCu0.1 Si3.8B14Cr1. 1 (x=0, 1, 5, 10) ribbons were annealed under magnetic field and tensile stress, respectively, and their magnetic properties were investigated. Fe73.5 Cu1 Nb3 Si15.5 B7 and...Amorphous Fe62-x Ni19CoxCu0.1 Si3.8B14Cr1. 1 (x=0, 1, 5, 10) ribbons were annealed under magnetic field and tensile stress, respectively, and their magnetic properties were investigated. Fe73.5 Cu1 Nb3 Si15.5 B7 and Fe66 Ni10- Cu1 Nb3Si11 B9 nanocrystalline alloy ribbons were also fabricated for comparison. Excellent DC tolerant property was obtained in the amorphous FeNiCoCuSiBCr ribbons after thermomagnetic treatment and the constant permeable property was improved with increasing Co content. The relative permeability was constant up to the DC bias field of approximately 6 ×10 ^-4 , 9 ×10 ^-4, and 10 × 10^-4 T and the values of relative permeability μ were 1 650, 1 200, and 1 000 with the Co content being 0, 5 at. %, and 10 at.%, respectively. Besides, stress-annealed FeNiCoCuSiBCr al- loy ribbons were proved to exhibit positive saturation magnetostriction constant λs.展开更多
Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,89...Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients.展开更多
基金supported by the funds of the National Natural Science Foundation of China (Nos. 11175194, 11875270, and U1832210)Youth Innovation Promotion Association CAS (No. 2018015)Guangdong Basic and Applied Basic Research Foundation (No.2019B1515120046)
文摘A waterproof nanocrystalline soft magnetic alloy core with a size of O.D.850 mm×I.D.316 mm×H.25 mm for radio frequency acceleration was successfully developed by winding 18μm 1k107b MA ribbons.Theμ'_(p)Qf products reached 7.5,10,and 12 GHz at 1,3,and 5 MHz,respectively.Theμ'_(p)Qf products of the MA core(O.D.250 mm×I.D.100 mm×H.25 mm)manufactured using a 13μm MA ribbon further increased by 30%.Detailed improvements on the MA core manufacture process are discussed herein.Continuous high-power tests on the new MA cores demonstrated its good performance of waterproofness,particularly its stability of highμ'_(p)Qf products.The MA core with highμ'pQf product and large size can operate under a high average RF power,high electric field,and in deionized water,which will be used in the China Spallation Neutron Source PhaseⅡ(CSNS-Ⅱ).
基金supported by the National Natural Science Foundation of China(Grant No.51909219)the National Key Research and Development Program of China(Grant No.2016YFC0301300)+1 种基金Fundamental Research Funds for the Central Universities(Grant No.3102019JC006)China Postdoctoral Science Foundation(Grand No.2020M673492)。
文摘The initial geometric imperfection is one of the primary factors affecting the buckling behaviors of composite cylindrical shells under hydrostatic pressure.In this study,ovality and thickness variations as two representative types of the geometric imperfections are considered.After measuring the geometric imperfections,a typical carbon fiber reinforced polymers(CFRP)cylindrical shell is tested to obtain the buckling pressure.The buckling behaviors of the shell sample are analyzed in combination with the strain responses.By using the nonlinear numerical analysis,the buckling shapes of the CFRP cylinder shells with different combinations of ovality and thickness variation are firstly discussed.The rules of influence of such imperfections on the buckling pressure are then obtained by nonlinear regression method.Finally,an empirical formula is proposed to predict the buckling pressure of the composite cylinder shells,and the calculated results from the formula are in good agreement with the numerical results.
文摘Crohn’s disease(CD)is a complex and relapsing gastrointestinal disease with mesenteric alterations.The mesenteric neural,vascular,and endocrine systems actively take part in the gut dysbiosis-adaptive immunity-mesentery-body axis,and this axis has been proven to be bidirectional.The abnormalities of morphology and function of the mesenteric component are associated with intestinal inflammation and disease progress of CD via responses to afferent signals,neuropeptides,lymphatic drainage,adipokines,and functional cytokines.The hypertrophy of mesenteric adipose tissue plays important roles in the pathogenesis of CD by secreting large amounts of adipokines and representing a rich source of proinflammatory or profibrotic cytokines.The vascular alteration,including angiogenesis and lymphangiogenesis,is concomitant in the disease course of CD.Of note,the enlarged and obstructed lymphatic vessels,which have been described in CD patients,are likely related to the early onset submucosa edema and being a cause of CD.The function of mesenteric lymphatics is influenced by endocrine of mesenteric nerves and adipocytes.Meanwhile,the structure of the mesenteric lymphatic vessels in hypertrophic mesenteric adipose tissue is mispatterned and ruptured,which can lead to lymph leakage.Leaky lymph factors can in turn stimulate adipose tissue to proliferate and effectively elicit an immune response.The identification of the role of mesentery and the crosstalk between mesenteric tissues in intestinal inflammation may shed light on understanding the underlying mechanism of CD and help explore new therapeutic targets.
基金supported by the Project of Science and Technology Program of Beijing Municipal Chao Yang District(CYSF2005,Zhun Li,http://www.bjchy.gov.cn/dynamic/notice/8a24fe83722fa7180172360a3f46044c.html).
文摘The building energy consumption is an important part among the total society energy consumption,in which the energy consumption for air conditioning occupies almost 70%.The energy consumption of the air conditioning system for fresh air handling can be saved effectively when the exhaust air energy could be recovered to preheat or precool the fresh air.Considering the install locations requirements on field,the pump-driven heat pipes(PHP)were developed as heat recovery ventilators(HRVs)and used in an existing experiment building in Beijing Urban.The thermal performance of the PHP HRVs was tested in real operation time periods under winter running mode.Both the power and heat consumption of the modular air handling units with and without HRVs were monitored and obtained,as well as the hourly power and heat consumption.The energy savings of HRVs were analyzed.The results indicate that the PHP HRVs can work steadily and meet the energy recovery need well.The temperature effectiveness of the HRVs can be kept from 60%to 70%.The test total energy saving rate was 24.48%,and the average hourly heat consumption reduced by 28.54%.The daily energy consumption can be saved by 118 kWh,and the energy savings can reach to 9440 kWh for a whole winter.
基金financially supported by the National Key R&D Program of China (No. 2021YFB3802800)the National Natural Science Foundation of China (Nos. 52101195, 51871120 and 52271147)+2 种基金the Natural Science Foundation of Jiangsu Province (Nos. BK20190480 and BK20200019)the Fundamental Research Funds for the Central Universities (Nos. 30920021156 and 30920010004)Guangdong-Hong Kong-Macao Joint Laboratory for Neutron Scattering Science and Technology。
文摘Metallic glasses(MGs) are promising heterogeneous catalysts in water remediation,due to their superior efficiency,selectivity,reusability and corrosion resistance.However,few works are focused on the influence of inorganic anions that are abundant in wastewater.Herein,four common inorganic anions were added in a heterogeneous Fenton-like system(Fe-MG/H_(2)O_(2)) to study inorganic anions' influence on MGs' catalytic performance during methylene blue(MB) degradation.Evidence demonstrated that chloride ions and dihydrogen phosphate ions had an adverse effect on the catalytic performance of Fe-MG,whereas Fe-MG/H_(2)O_(2) system sustained high efficiency in the presence of sulfate ions and nitrate ions during the Fenton-like process.By studying the structure,surface morphology,and evolution of active species,it was found that inorganic anions had a significant effect on the surface morphology of Fe-MG and the generation of active species.This work will provide essential references for MGs as heterogeneous catalysts in practical applications.
基金supported by the National Natural Science Foundation of China(Nos.82270543,82170573,81770556 and 21874066)the National Key R&D Program of China(No.2019YFA0709200)+3 种基金the Key Research and Development Program of Jiangsu Province(No.BE2021373)the Natural Science Foundation of Jiangsu Province(No.BK20200336)the Fundamental Research Funds for Central Universities,and the Program for Innovative Talents and Entrepreneur in Jiangsu.All animal studies were approved by the Ethics Committee of Jinling Hospital(No.2021JLHDWLSZ-0010)Surgical specimens were collected from Department of Gastroenterology and Hepatology,General Hospital of Eastern Theater Command.The use of human biopsies was approved by the Ethics Committee of Jinling Hospital(No.2022DZKY-048-01).All patients enrolled were given informed written consent.
文摘Inflammatory bowel disease(IBD)is an autoimmune gastrointestinal disease characterized by chronic relapsing inflammation of the intestine.Excessive pyroptosis that exists in the inflamed intestine can activate damage signals and aggravate local inflammation in IBD.Here,we designed an oral pyroptosis nanoinhibitor,DXMS@CuM@PPADT@PSS(DCMP),which can target intestinal lesions,and respond to reactive oxygen species(ROS)to release active sites and drugs at the lesion.DCMP can inhibit the activation of the nucleotide-binding domain and leucine-rich repeat family pyrin domain containing 3(NLRP3)inflammasomes by scavenging ROS,resulting in the down-regulation of gasdermin D(GSDMD)cleavage thus inhibiting pyroptosis.It also improved intestinal barrier function,decreased inflammatory cytokine levels,and increased the diversity of gut microbiota in mice with colitis.This work is believed to expand the biomedical application of nanomaterials for innate immunity modulation.
基金This work was supported by the National Key Basic Research and Development Programme (Grant No.2016YFB0300500) and the National Natural Science Foundation of China (NSFC, Grant Nos. 51571127 and 51771096).
文摘Three-dimensional flowerlike nanostructured metal oxides attached on the surfaces of Fe-based multi-phase nanocrys- talline ribbons (Fe-MNRs) were prepared by a simple way (through immersing the Fe-MNRs in Orange II solution). It has been found that the as-prepared Fe-MNRs with 3D flowerlike nanostructures (Fe-MNRs + FNs) exhibit good absorption property for a typical heavy metal ion (Cr^VI) in wastewater, while Fe-MNRs do not possess such properties. The Fe-MNRs + FNs could remove 99% CrvI ions from the solution in 40 min, and this adsorption property can be attributed to the ion exchange between Cr^VI and surface hydroxyl groups (O-H) of 3D flowerlike nanostructures. The present result suggests that the Fe-MNRs + FNs, prepared by facile way, possess great potentials in removing heavy metallic ions in wastewater.
文摘In the version of the article originally published in the volume 63,ssue 3,2020 of Sci China Mater(2020,63(3):453-46,https:/doi.org/10.1007/s40843-019-1205-5),the affiliations of the authors were incorrectly labeled.
基金Financial supports from National Natural Science Foundation of China(Grant No.of 71472025 and 71972027)the Fund for Cultural Celebrity and Talents(Grant No.of[2015]49)are gratefully acknowledged.
文摘This study investigates the impacts of contraction flexibility and operating leverage onfinancial leverage from the perspective of the agency conflict between shareholders and debtholders.In a continuous-time real option framework,we demonstrate that share-holders'contraction flexibility may have an adverse effect on financial leverage,and that the substitution relation between operating leverage andfinancial leverage is persistent or pronounced in the presence of contraction flexibility.The evidence from Chinese listedfirms not only supports our theoretical predictions well,but also offers a method to examine the agency conflict hypothesis.We suggest that the high proportion of bank loans or long-term debt in total liabilities can help levered firms alleviate the agency problem arising from contraction decisions.
基金financially supported by the National Natural Science Foundation of China (NSFC, 51871129 and 51571127)the National Key Basic Research and Development Programme (2016YFB0300502)the Natural Science Foundation of Jiangsu Province (BK20190480)
基金Sponsored by National High-tech Research and Development Program of China(2012AA030301)National Natural Science Foundation of China(51071050)
文摘Amorphous Fe62-x Ni19CoxCu0.1 Si3.8B14Cr1. 1 (x=0, 1, 5, 10) ribbons were annealed under magnetic field and tensile stress, respectively, and their magnetic properties were investigated. Fe73.5 Cu1 Nb3 Si15.5 B7 and Fe66 Ni10- Cu1 Nb3Si11 B9 nanocrystalline alloy ribbons were also fabricated for comparison. Excellent DC tolerant property was obtained in the amorphous FeNiCoCuSiBCr ribbons after thermomagnetic treatment and the constant permeable property was improved with increasing Co content. The relative permeability was constant up to the DC bias field of approximately 6 ×10 ^-4 , 9 ×10 ^-4, and 10 × 10^-4 T and the values of relative permeability μ were 1 650, 1 200, and 1 000 with the Co content being 0, 5 at. %, and 10 at.%, respectively. Besides, stress-annealed FeNiCoCuSiBCr al- loy ribbons were proved to exhibit positive saturation magnetostriction constant λs.
基金funded by the Guangzhou Institute of Respiratory Health Open Project (Funds provided by the China Evergrande Group) (2020GIRHHMS14)Zhongnanshan Medical Foundation of Guangdong Province (ZNSA-2020003)+1 种基金the Department of Science and Technology of Guangdong Province (2020 B1111340004)the Traditional Chinese Medicine Bureau of Guangdong Province (2020ZYYJ05)。
文摘Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients.