DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine (<(DP)over bar> 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA. The resultant polymer chelates were f...DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine (<(DP)over bar> 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA. The resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose to give liver-specific contrast agents for magnetic resonance imaging. These new polymer conjugates were characterized by FT-IR, ICP-AES, UV-Vis spectrophotometry and elemental analysis. Their in vitro spin-lattice relaxivity and body distribution in mice were investigated.展开更多
A series of amino acids and oligopeptidyl derivatives of GdDTPA were synthesized.The structure of these chelates were confirmed by IR and elementary analysis .Toxicity of chelates was almost the same as Gd-DTPA. The ...A series of amino acids and oligopeptidyl derivatives of GdDTPA were synthesized.The structure of these chelates were confirmed by IR and elementary analysis .Toxicity of chelates was almost the same as Gd-DTPA. The spin- lattice relaxivity (R1) of these chelates were s little bit larger than that of Gd-DTPA.展开更多
A novel crosslinking polyphosphate was synthesized. The polymer was characterized by FT-IR, (HNMR)-H-1, (PNMR)-P-31 nd elemental analysis, In vitro release of Levonorgestrel by single-matrix and sandwich pellet with p...A novel crosslinking polyphosphate was synthesized. The polymer was characterized by FT-IR, (HNMR)-H-1, (PNMR)-P-31 nd elemental analysis, In vitro release of Levonorgestrel by single-matrix and sandwich pellet with polyphosphate as drug carrier were carried out in pH 7.4 phosphate buffer solution at 37 degreesC, Sustained release rate from-the sandwich pellet was more controlled than that from single-matrix pellet.展开更多
A series of copolymers of N-isopropylacrylamide and N-acryloxysuccinimide with different active ester contents and different molecular weights and their conjugates with IgG were prepared.The properties of copolymers a...A series of copolymers of N-isopropylacrylamide and N-acryloxysuccinimide with different active ester contents and different molecular weights and their conjugates with IgG were prepared.The properties of copolymers and IgG-bearing polymers were studied.展开更多
The surface of silica gels was modified by an diethylamino group and an hydroxy group, simultaneously. The activity of the aminoacylase immobilized on such amino-hydroxy-silica gels was 316.8 U/g. By its catalysis, th...The surface of silica gels was modified by an diethylamino group and an hydroxy group, simultaneously. The activity of the aminoacylase immobilized on such amino-hydroxy-silica gels was 316.8 U/g. By its catalysis, the conversions of tested N-acetyl-D,L-amino acids to L-amino acids were 85%.展开更多
Using amino-poly(ethylene glycol) and amino-propyl silica gel as initiator cores, two dendrimers were prepared by a two-step procedure. The progress of dendrimers during each step was monitored by infrared spectroscop...Using amino-poly(ethylene glycol) and amino-propyl silica gel as initiator cores, two dendrimers were prepared by a two-step procedure. The progress of dendrimers during each step was monitored by infrared spectroscopy and elemental analysis. Papain was crosslinked to the solid dendrimer with silica gel core by glutaraldehyde, and the enzymatic activity of the immobilized papain kept almost unchanged after repeated usage for fifteen times.展开更多
文摘DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine (<(DP)over bar> 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA. The resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose to give liver-specific contrast agents for magnetic resonance imaging. These new polymer conjugates were characterized by FT-IR, ICP-AES, UV-Vis spectrophotometry and elemental analysis. Their in vitro spin-lattice relaxivity and body distribution in mice were investigated.
文摘A series of amino acids and oligopeptidyl derivatives of GdDTPA were synthesized.The structure of these chelates were confirmed by IR and elementary analysis .Toxicity of chelates was almost the same as Gd-DTPA. The spin- lattice relaxivity (R1) of these chelates were s little bit larger than that of Gd-DTPA.
文摘A novel crosslinking polyphosphate was synthesized. The polymer was characterized by FT-IR, (HNMR)-H-1, (PNMR)-P-31 nd elemental analysis, In vitro release of Levonorgestrel by single-matrix and sandwich pellet with polyphosphate as drug carrier were carried out in pH 7.4 phosphate buffer solution at 37 degreesC, Sustained release rate from-the sandwich pellet was more controlled than that from single-matrix pellet.
文摘A series of copolymers of N-isopropylacrylamide and N-acryloxysuccinimide with different active ester contents and different molecular weights and their conjugates with IgG were prepared.The properties of copolymers and IgG-bearing polymers were studied.
文摘The surface of silica gels was modified by an diethylamino group and an hydroxy group, simultaneously. The activity of the aminoacylase immobilized on such amino-hydroxy-silica gels was 316.8 U/g. By its catalysis, the conversions of tested N-acetyl-D,L-amino acids to L-amino acids were 85%.
文摘Using amino-poly(ethylene glycol) and amino-propyl silica gel as initiator cores, two dendrimers were prepared by a two-step procedure. The progress of dendrimers during each step was monitored by infrared spectroscopy and elemental analysis. Papain was crosslinked to the solid dendrimer with silica gel core by glutaraldehyde, and the enzymatic activity of the immobilized papain kept almost unchanged after repeated usage for fifteen times.
