Exploring novel therapeutic targets of Diffuse large B cell lymphoma(DLBCL)to overcome its resistance to Bruton's Tyrosine Kinase(BTK)inhibitors is a key topic.Lipid metabolism,crucial in the resistance landscape ...Exploring novel therapeutic targets of Diffuse large B cell lymphoma(DLBCL)to overcome its resistance to Bruton's Tyrosine Kinase(BTK)inhibitors is a key topic.Lipid metabolism,crucial in the resistance landscape of various cancers,may unlock new aspects of BTK inhibitor resistance in DLBCL.Despite the known importance of lipid metabolism in oncological resistance patterns,its intricate role in DLBCL and its resistance to BTK inhibitor therapies remains largely uncharted.This review will explore the complex relationship between lipid metabolism and BTK inhibitor resistance,giving new insights for improving the effectiveness of BTK inhibitors and developing innovative combination treatment methods for DLBCL.This review holds the potential for guiding future research directions,optimizing existing therapeutic processes,and inspiring the development of innovative combinatorial therapeutic strategies that improve outcomes in patients with DLBCL.展开更多
Microcavities constructed from materials with a second-order nonlinear coefficient have enabled efficient second-harmonic(SH)generation at a low power level.However,it is still technically challenging to realize doubl...Microcavities constructed from materials with a second-order nonlinear coefficient have enabled efficient second-harmonic(SH)generation at a low power level.However,it is still technically challenging to realize double resonance with large nonlinear modal overlap in a microcavity.Here,we propose a design for a robust,tunable,and easy coupling double-resonance SH generation based on the combination of a newly developed fiber-based Fabry-Perot microcavity and a sandwich structure,whose numerical SH conversion efficiency is up to 3000%W^(-1).This proposal provides a feasible way to construct ultra-efficient nonlinear devices for generation of classical and quantum light sources.展开更多
A secret sharing scheme permits a secret to be shared among participants in such a way that only qualified subsets of participants can recover the secret. Secret sharing is useful in management of cryptographic keys. ...A secret sharing scheme permits a secret to be shared among participants in such a way that only qualified subsets of participants can recover the secret. Secret sharing is useful in management of cryptographic keys. Based on identity, we analyze the secret sharing scheme among weighted participants. Then we present a dynamic scheme about secret sharing among weighted participants. At last, we analyze the secret sharing scheme among weighted participants, which can make all weighted participants verifiable and dynamic.展开更多
Vaccination interventions is consideredan important preventive measure to block the transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and protect the organism from pathogen infection effective...Vaccination interventions is consideredan important preventive measure to block the transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and protect the organism from pathogen infection effectively.However,a quick and accurate technique to evaluate the immune efficacy of the SARS-CoV-2 inactivated vaccine remains scarce.In this paper,an IgM-IgG antibody combined detection colloidal gold immunochromatography assay kit was optimized and developed,which can assess the efficacy of the inactivated SARS-CoV-2 vaccine.We collected fingertip blood samples from 3 vaccinees and 1 unvaccinated sample.The results showed that the proportion of antibody was high after the second shots immunization.The colloidal gold-based immunochromatographic strip is rapid,convenient and easy to operate.It can be used as an auxiliary method for preliminary evaluation of the antibody effect of vaccine recipients,and provide a reference index for the potential clinical application value of the vaccine.展开更多
基金supported by the Academic Excellence Foundation of BUAA for PhD Students.
文摘Exploring novel therapeutic targets of Diffuse large B cell lymphoma(DLBCL)to overcome its resistance to Bruton's Tyrosine Kinase(BTK)inhibitors is a key topic.Lipid metabolism,crucial in the resistance landscape of various cancers,may unlock new aspects of BTK inhibitor resistance in DLBCL.Despite the known importance of lipid metabolism in oncological resistance patterns,its intricate role in DLBCL and its resistance to BTK inhibitor therapies remains largely uncharted.This review will explore the complex relationship between lipid metabolism and BTK inhibitor resistance,giving new insights for improving the effectiveness of BTK inhibitors and developing innovative combination treatment methods for DLBCL.This review holds the potential for guiding future research directions,optimizing existing therapeutic processes,and inspiring the development of innovative combinatorial therapeutic strategies that improve outcomes in patients with DLBCL.
基金supported by the National Key R&D Program of China(2021YFA1400803)the National Natural Science Foundation of China(No.12204019)+1 种基金the China Postdoctoral Science Foundation(No.2022M710233)the National PostdoctoralProgramforInnovativeTalents(No.BX20220010)。
文摘Microcavities constructed from materials with a second-order nonlinear coefficient have enabled efficient second-harmonic(SH)generation at a low power level.However,it is still technically challenging to realize double resonance with large nonlinear modal overlap in a microcavity.Here,we propose a design for a robust,tunable,and easy coupling double-resonance SH generation based on the combination of a newly developed fiber-based Fabry-Perot microcavity and a sandwich structure,whose numerical SH conversion efficiency is up to 3000%W^(-1).This proposal provides a feasible way to construct ultra-efficient nonlinear devices for generation of classical and quantum light sources.
基金The research is supported by Research Funds of Information Security and Secrecy Laboratory of Beijing Electronic Science ＆： Technology Institute under Grant No. YZDJ0712, partially by National Basic Research Program under Grant No. 2004CB318000, and Beijing Municipal Natural Science Foundation under Grant No. 406：3040.
文摘A secret sharing scheme permits a secret to be shared among participants in such a way that only qualified subsets of participants can recover the secret. Secret sharing is useful in management of cryptographic keys. Based on identity, we analyze the secret sharing scheme among weighted participants. Then we present a dynamic scheme about secret sharing among weighted participants. At last, we analyze the secret sharing scheme among weighted participants, which can make all weighted participants verifiable and dynamic.
基金This work was supported by the National Natural Science Foundation of China[grant number 81970186].
文摘Vaccination interventions is consideredan important preventive measure to block the transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and protect the organism from pathogen infection effectively.However,a quick and accurate technique to evaluate the immune efficacy of the SARS-CoV-2 inactivated vaccine remains scarce.In this paper,an IgM-IgG antibody combined detection colloidal gold immunochromatography assay kit was optimized and developed,which can assess the efficacy of the inactivated SARS-CoV-2 vaccine.We collected fingertip blood samples from 3 vaccinees and 1 unvaccinated sample.The results showed that the proportion of antibody was high after the second shots immunization.The colloidal gold-based immunochromatographic strip is rapid,convenient and easy to operate.It can be used as an auxiliary method for preliminary evaluation of the antibody effect of vaccine recipients,and provide a reference index for the potential clinical application value of the vaccine.
